PMID- 33251856
OWN - NLM
STAT- MEDLINE
DCOM- 20210414
LR  - 20210414
IS  - 1744-8395 (Electronic)
IS  - 1476-0584 (Linking)
VI  - 19
IP  - 11
DP  - 2020 Nov
TI  - Research progress in the development of porcine reproductive and respiratory 
      syndrome virus as a viral vector for foreign gene expression and delivery.
PG  - 1041-1051
LID - 10.1080/14760584.2020.1857737 [doi]
AB  - INTRODUCTION: Porcine reproductive and respiratory syndrome (PRRS) is an 
      infectious disease of swine characterized by respiratory disorders in growing and 
      finishing pigs and reproductive failure in pregnant sows. PRRSV has been 
      recognized as one of the most economically significant pathogens affecting the 
      global pig industry. AREAS COVERED: Currently, commercially available vaccines, 
      including traditional killed virus (KV) vaccines and modified live virus (MLV) 
      vaccines, are the cardinal approaches to prevent and control porcine reproductive 
      and respiratory syndrome virus (PRRSV) infection. However, the protective 
      efficacy of these vaccines is not satisfactory, resulting in the continuous 
      evolution and recurrent appearance of the virus as well as the emergence of new 
      variants. A safe and effective vaccine against PRRSV is in dire need. Here, we 
      review the research progress in recent years in the development and use of PRRSV 
      as a viral vector to express foreign genes, and their potential application in 
      gene delivery and vaccine development. EXPERT OPINION: The potential of using 
      PRRSV-based vectors to express multiple antigens would be particularly 
      instrumental for the development of a new generation of multivalent vaccines 
      against PRRSV and other porcine viruses.
FAU - Dai, Guo
AU  - Dai G
AD  - Guangdong Province Key Laboratory of Microbial Signals & Disease Control and 
      Integrative Microbiol , Guangzhou, Guangdong, People's Republic of China.
FAU - Huang, Mei
AU  - Huang M
AD  - Zhaoqing Institute of Biotechnology Co., Ltd ., Zhaoqing, Guangdong, People's 
      Republic of China.
FAU - Fung, To Sing
AU  - Fung TS
AD  - Guangdong Province Key Laboratory of Microbial Signals & Disease Control and 
      Integrative Microbiol , Guangzhou, Guangdong, People's Republic of China.
FAU - Liu, Ding Xiang
AU  - Liu DX
AD  - Guangdong Province Key Laboratory of Microbial Signals & Disease Control and 
      Integrative Microbiol , Guangzhou, Guangdong, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201210
PL  - England
TA  - Expert Rev Vaccines
JT  - Expert review of vaccines
JID - 101155475
RN  - 0 (Antigens, Viral)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antigens, Viral/immunology
MH  - Gene Expression
MH  - Genetic Vectors
MH  - Porcine Reproductive and Respiratory Syndrome/immunology/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/genetics/*immunology
MH  - Swine
MH  - Vaccination
MH  - Viral Vaccines/*administration & dosage/immunology
OTO - NOTNLM
OT  - Porcine reproductive and respiratory syndrome virus
OT  - foreign genes
OT  - infectious clone
OT  - vaccine
OT  - viral vector
EDAT- 2020/12/01 06:00
MHDA- 2021/04/15 06:00
CRDT- 2020/11/30 08:40
PHST- 2020/12/01 06:00 [pubmed]
PHST- 2021/04/15 06:00 [medline]
PHST- 2020/11/30 08:40 [entrez]
AID - 10.1080/14760584.2020.1857737 [doi]
PST - ppublish
SO  - Expert Rev Vaccines. 2020 Nov;19(11):1041-1051. doi: 
      10.1080/14760584.2020.1857737. Epub 2020 Dec 10.