PMID- 33253889
OWN - NLM
STAT- MEDLINE
DCOM- 20211220
LR  - 20211220
IS  - 1522-9653 (Electronic)
IS  - 1063-4584 (Linking)
VI  - 29
IP  - 3
DP  - 2021 Mar
TI  - The role of stromal cell-derived factor 1 on cartilage development and disease.
PG  - 313-322
LID - S1063-4584(20)31195-X [pii]
LID - 10.1016/j.joca.2020.10.010 [doi]
AB  - Stromal cell-derived factor 1 (SDF-1), also known as CXC motif chemokine ligand 
      12 (CXCL12), is recognized as a homeostatic cytokine with strong chemotactic 
      potency. It plays an important role in physiological and pathological processes, 
      such as the development of multiple tissues and organs, the regulation of cell 
      distribution, and tumour metastasis. SDF-1 has two receptors, CXC chemokine 
      receptor type 4 (CXCR4) and CXC chemokine receptor type 7 (CXCR7). SDF-1 affects 
      the proliferation, survival, differentiation and maturation of chondrocytes by 
      binding to CXCR4 on chondrocytes. Therefore, SDF-1 has been used as an exogenous 
      regulatory target in many studies to explore the mechanism of cartilage 
      development. SDF-1 is also a potential therapeutic target for osteoarthritis (OA) 
      and rheumatoid arthritis (RA), because of its role in pathological initiation and 
      regulation. In addition, SDF-1 shows potent capacity in the repair of cartilage 
      defects by recruiting endogenous stem cells in a cartilage tissue engineering 
      context. To summarize the specific role of SDF-1 on cartilage development and 
      disease, all articles had been screened out in PubMed by May 30, 2020. The search 
      was limited to studies published in English. Search terms included SDF-1; CXCL12; 
      CXCR4; chondrocyte; cartilage; OA; RA, and forty-seven papers were studied. 
      Besides, we reviewed references in the articles we searched to get additional 
      relevant backgrounds. The review aims to conclude the current knowledge regarding 
      the physiological and pathological role of SDF-1 on the cartilage and 
      chondrocyte. More investigations are required to determine methods targeted SDF-1 
      to cartilage development and interventions to cartilage diseases.
CI  - Copyright (c) 2020 Osteoarthritis Research Society International. Published by 
      Elsevier Ltd. All rights reserved.
FAU - Li, J
AU  - Li J
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, 
      Sichuan University, Chengdu 610041, China.
FAU - Chen, H
AU  - Chen H
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, 
      Sichuan University, Chengdu 610041, China.
FAU - Zhang, D
AU  - Zhang D
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, 
      Sichuan University, Chengdu 610041, China.
FAU - Xie, J
AU  - Xie J
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, 
      Sichuan University, Chengdu 610041, China. Electronic address: 
      xiejing2012@scu.edu.cn.
FAU - Zhou, X
AU  - Zhou X
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, 
      Sichuan University, Chengdu 610041, China; Department of Cariology and 
      Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 
      610041, China. Electronic address: zhouxd@scu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201127
PL  - England
TA  - Osteoarthritis Cartilage
JT  - Osteoarthritis and cartilage
JID - 9305697
RN  - 0 (ACKR3 protein, human)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Receptors, CXCR)
RN  - 0 (Receptors, CXCR4)
SB  - IM
MH  - Arthritis, Rheumatoid/*metabolism/physiopathology
MH  - Cartilage Diseases/metabolism/physiopathology
MH  - Cell Differentiation/physiology
MH  - Cell Proliferation/physiology
MH  - Cell Survival
MH  - Chemokine CXCL12/*metabolism/physiology
MH  - Chondrocytes/*physiology
MH  - Chondrogenesis/*physiology
MH  - Humans
MH  - Osteoarthritis/*metabolism/physiopathology
MH  - Receptors, CXCR/physiology
MH  - Receptors, CXCR4/physiology
OTO - NOTNLM
OT  - Chondrocyte
OT  - Differentiation
OT  - Osteoarthritis
OT  - Rheumatoid arthritis
OT  - Stromal cell-derived factor 1
EDAT- 2020/12/01 06:00
MHDA- 2021/12/21 06:00
CRDT- 2020/11/30 20:11
PHST- 2020/06/09 00:00 [received]
PHST- 2020/09/11 00:00 [revised]
PHST- 2020/10/06 00:00 [accepted]
PHST- 2020/12/01 06:00 [pubmed]
PHST- 2021/12/21 06:00 [medline]
PHST- 2020/11/30 20:11 [entrez]
AID - S1063-4584(20)31195-X [pii]
AID - 10.1016/j.joca.2020.10.010 [doi]
PST - ppublish
SO  - Osteoarthritis Cartilage. 2021 Mar;29(3):313-322. doi: 
      10.1016/j.joca.2020.10.010. Epub 2020 Nov 27.