PMID- 33254709
OWN - NLM
STAT- MEDLINE
DCOM- 20201204
LR  - 20231112
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Print)
IS  - 0269-7491 (Linking)
VI  - 267
DP  - 2020 Dec
TI  - The short- and long-term associations of particulate matter with inflammation and 
      blood coagulation markers: A meta-analysis.
PG  - 115630
LID - S0269-7491(20)36318-1 [pii]
LID - 10.1016/j.envpol.2020.115630 [doi]
LID - 115630
AB  - Inflammation and the coagulation cascade are considered to be the potential 
      mechanisms of ambient particulate matter (PM) exposure-induced adverse 
      cardiovascular events. Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), 
      interleukin-8 (IL-8), and fibrinogen are arguably the four most commonly assayed 
      markers to reflect the relationships of PM with inflammation and blood 
      coagulation. This review summarized and quantitatively analyzed the existing 
      studies reporting short- and long-term associations of PM(2.5)(PM with an 
      aerodynamic diameter </=2.5 mum)/PM(10) (PM with an aerodynamic diameter</=10 mum) with 
      important inflammation and blood coagulation markers (TNF-alpha, IL-6, IL-8, 
      fibrinogen). We reviewed relevant studies published up to July 2020, using three 
      English databases (PubMed, Web of Science, Embase) and two Chinese databases 
      (Wang-Fang, China National Knowledge Infrastructure). The OHAT tool, with some 
      modification, was applied to evaluate risk of bias. Meta-analyses were conducted 
      with random-effects models for calculating the pooled estimate of markers. To 
      assess the potential effect modifiers and the source of heterogeneity, we 
      conducted subgroup analyses and meta-regression analyses where appropriate. The 
      assessment and correction of publication bias were based on Begg's and Egger's 
      test and "trim-and-fill" analysis. We identified 44 eligible studies. For 
      short-term PM exposure, the percent change of a 10 mug/m(3) PM(2.5) increase on 
      TNF-alpha and fibrinogen was 3.51% (95% confidence interval (CI): 1.21%, 5.81%) and 
      0.54% (95% confidence interval (CI): 0.21%, 0.86%) respectively. We also found a 
      significant short-term association between PM(10) and fibrinogen (percent 
      change = 0.17%, 95% CI: 0.04%, 0.29%). Overall analysis showed that long-term 
      associations of fibrinogen with PM(2.5) and PM(10) were not significant. Subgroup 
      analysis showed that long-term associations of fibrinogen with PM(2.5) and PM(10) 
      were significant only found in studies conducted in Asia. Our findings support 
      significant short-term associations of PM with TNF-alpha and fibrinogen. Future 
      epidemiological studies should address the role long-term PM exposure plays in 
      inflammation and blood coagulation markers level change.
CI  - Copyright (c) 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
FAU - Tang, Hong
AU  - Tang H
AD  - Department of Global Health, School of Health Sciences, Wuhan University, 115# 
      Donghu Road, Wuhan, China; Global Health Institute, Wuhan University, 115# Donghu 
      Road, Wuhan, China.
FAU - Cheng, Zilu
AU  - Cheng Z
AD  - School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of 
      Technology, 122# Luoshi Road, Wuhan, China.
FAU - Li, Na
AU  - Li N
AD  - Department of Global Health, School of Health Sciences, Wuhan University, 115# 
      Donghu Road, Wuhan, China; Global Health Institute, Wuhan University, 115# Donghu 
      Road, Wuhan, China.
FAU - Mao, Shuyuan
AU  - Mao S
AD  - Department of Global Health, School of Health Sciences, Wuhan University, 115# 
      Donghu Road, Wuhan, China; Global Health Institute, Wuhan University, 115# Donghu 
      Road, Wuhan, China.
FAU - Ma, Runxue
AU  - Ma R
AD  - Department of Global Health, School of Health Sciences, Wuhan University, 115# 
      Donghu Road, Wuhan, China.
FAU - He, Haijun
AU  - He H
AD  - Department of Global Health, School of Health Sciences, Wuhan University, 115# 
      Donghu Road, Wuhan, China.
FAU - Niu, Zhiping
AU  - Niu Z
AD  - Department of Global Health, School of Health Sciences, Wuhan University, 115# 
      Donghu Road, Wuhan, China; Global Health Institute, Wuhan University, 115# Donghu 
      Road, Wuhan, China.
FAU - Chen, Xiaolu
AU  - Chen X
AD  - Department of Global Health, School of Health Sciences, Wuhan University, 115# 
      Donghu Road, Wuhan, China; Global Health Institute, Wuhan University, 115# Donghu 
      Road, Wuhan, China.
FAU - Xiang, Hao
AU  - Xiang H
AD  - Department of Global Health, School of Health Sciences, Wuhan University, 115# 
      Donghu Road, Wuhan, China; Global Health Institute, Wuhan University, 115# Donghu 
      Road, Wuhan, China. Electronic address: xianghao@whu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20200910
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Air Pollutants)
RN  - 0 (Particulate Matter)
SB  - IM
MH  - *Air Pollutants
MH  - *Air Pollution
MH  - Asia
MH  - Blood Coagulation
MH  - China
MH  - Environmental Exposure
MH  - Humans
MH  - Inflammation
MH  - Particulate Matter
PMC - PMC7687019
OTO - NOTNLM
OT  - Blood coagulation
OT  - Inflammation
OT  - Meta-analysis
OT  - Particulate matter
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/12/02 06:00
MHDA- 2020/12/15 06:00
PMCR- 2020/12/01
CRDT- 2020/12/01 01:02
PHST- 2020/06/17 00:00 [received]
PHST- 2020/08/31 00:00 [revised]
PHST- 2020/09/07 00:00 [accepted]
PHST- 2020/12/01 01:02 [entrez]
PHST- 2020/12/02 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/12/01 00:00 [pmc-release]
AID - S0269-7491(20)36318-1 [pii]
AID - 115630 [pii]
AID - 10.1016/j.envpol.2020.115630 [doi]
PST - ppublish
SO  - Environ Pollut. 2020 Dec;267:115630. doi: 10.1016/j.envpol.2020.115630. Epub 2020 
      Sep 10.