PMID- 33256114 OWN - NLM STAT- MEDLINE DCOM- 20210419 LR - 20210419 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 12 IP - 12 DP - 2020 Nov 26 TI - Effects of High and Low Protein Diets on Inflammatory Profiles in People with Morbid Obesity: A 3-Week Intervention Study. LID - 10.3390/nu12123636 [doi] LID - 3636 AB - Nutritional interventions in morbidly obese individuals that effectively reverse a pro-inflammatory state and prevent obesity-associated medical complications are highly warranted. Our aim was to evaluate the effect of high (HP) or low (LP) protein diets on circulating immune-inflammatory biomarkers, including C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-a), interleukin-10 (IL-10), monocyte chemoattractant protein-1 (MCP-1), chemerin, omentin, leptin, total adiponectin, high molecular weight adiponectin, and fetuin-A. With this aim, 18 people with morbid obesity were matched into two hypocaloric groups: HP (30E% protein, n = 8) and LP (10E% protein, n = 10) for three weeks. Biomarkers were measured pre and post intervention and linear mixed-effects models were used to investigate differences. Consuming HP or LP diets resulted in reduced CRP (HP: -2.2 +/- 1.0 mg/L, LP: -2.3 +/- 0.9 mg/L) and chemerin (HP: -17.9 +/- 8.6 ng/mL, LP: -20.0 +/- 7.4 ng/mL), with no statistically significant differences by diet arm. Participants following the LP diet showed a more pronounced decrease in leptin (-19.2 +/- 6.0 ng/mL) and IL-6 (-0.4 +/- 0.1 pg/mL) and an increase in total adiponectin (1.6 +/- 0.6 microg/mL). Changes were also observed for the remaining biomarkers to a smaller degree by the HP than the LP hypocaloric diet, suggesting that a LP hypocaloric diet modulates a wider range of immune inflammatory biomarkers in morbidly obese individuals. FAU - Koelman, Liselot AU - Koelman L AD - Senior Scientist Group Nutrition, Immunity and Metabolism, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany. AD - Institute of Nutritional Science, University of Potsdam, 14558 Nuthetal, Germany. FAU - Markova, Mariya AU - Markova M AD - Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany. AD - German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany. FAU - Seebeck, Nicole AU - Seebeck N AD - Institute of Nutritional Science, University of Potsdam, 14558 Nuthetal, Germany. AD - Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany. AD - German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany. FAU - Hornemann, Silke AU - Hornemann S AD - Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany. AD - German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany. FAU - Rosenthal, Anke AU - Rosenthal A AD - Clinic for Nutritional Medicine, 10625 Berlin, Germany. FAU - Lange, Volker AU - Lange V AD - Center for Obesity and Metabolic Surgery, Vivantes Hospital, 13585 Berlin, Germany. AD - Helios Klinikum Berlin-Buch, 13125 Berlin, Germany. FAU - Pivovarova-Ramich, Olga AU - Pivovarova-Ramich O AUID- ORCID: 0000-0002-3583-8546 AD - Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany. AD - German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany. AD - Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, 12200 Berlin, Germany. AD - Research Group Molecular Nutritional Medicine, Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany. FAU - Aleksandrova, Krasimira AU - Aleksandrova K AD - Senior Scientist Group Nutrition, Immunity and Metabolism, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany. AD - Institute of Nutritional Science, University of Potsdam, 14558 Nuthetal, Germany. AD - Department Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology-BIPS, 28359 Bremen, Germany. LA - eng GR - Identification of individual response criteria for reduction of hepatic fat by nutritional approaches and subsequent maintenance by dietary strategies/European Association for the Study of Diabetes/ GR - Is FGF21 as novel bidirectional regulator of protein preference and aversion: regulatory mechanisms and clinical implications/Deutsche Zentrum fur Diabetesforschung/ GR - Role of Wnt-inducible signaling pathway protein-1 (WISP-1) in adipose tissue and liver fibrosis in mice and men/Deutsche Zentrum fur Diabetesforschung/ PT - Journal Article DEP - 20201126 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Adiponectin) RN - 0 (Biomarkers) RN - 0 (Chemokine CCL2) RN - 0 (Chemokines) RN - 0 (Cytokines) RN - 0 (Dietary Proteins) RN - 0 (GPI-Linked Proteins) RN - 0 (ITLN1 protein, human) RN - 0 (Interleukin-6) RN - 0 (Lectins) RN - 0 (Leptin) RN - 0 (RARRES2 protein, human) RN - 0 (Tumor Necrosis Factor-alpha) RN - 130068-27-8 (Interleukin-10) RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Adiponectin/blood MH - Adult MH - Biomarkers/blood MH - C-Reactive Protein MH - Chemokine CCL2/blood MH - Chemokines/blood MH - Cytokines/blood MH - Diet, High-Protein/*methods MH - Diet, Protein-Restricted/*methods MH - Dietary Proteins/administration & dosage MH - Female MH - GPI-Linked Proteins/blood MH - Humans MH - Inflammation/*blood/*diet therapy MH - Interleukin-10/blood MH - Interleukin-6/blood MH - Lectins/blood MH - Leptin/blood MH - Male MH - Middle Aged MH - Obesity, Morbid/*blood/*diagnostic imaging MH - Tumor Necrosis Factor-alpha/blood PMC - PMC7759799 OTO - NOTNLM OT - high protein OT - inflammatory biomarkers OT - low protein OT - morbid obesity OT - nutritional intervention COIS- The authors declare no conflict of interest. EDAT- 2020/12/02 06:00 MHDA- 2021/04/20 06:00 PMCR- 2020/11/26 CRDT- 2020/12/01 01:10 PHST- 2020/10/20 00:00 [received] PHST- 2020/11/16 00:00 [revised] PHST- 2020/11/24 00:00 [accepted] PHST- 2020/12/01 01:10 [entrez] PHST- 2020/12/02 06:00 [pubmed] PHST- 2021/04/20 06:00 [medline] PHST- 2020/11/26 00:00 [pmc-release] AID - nu12123636 [pii] AID - nutrients-12-03636 [pii] AID - 10.3390/nu12123636 [doi] PST - epublish SO - Nutrients. 2020 Nov 26;12(12):3636. doi: 10.3390/nu12123636.