PMID- 33256661
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Nov 30
TI  - Associations of serum uric acid and urinary albumin with the severity of diabetic 
      retinopathy in individuals with type 2 diabetes.
PG  - 467
LID - 10.1186/s12886-020-01713-5 [doi]
LID - 467
AB  - BACKGROUND: Diabetic retinopathy (DR) is a serious microvascular complication of 
      type 2 diabetes mellitus (T2DM). The aim of this retrospective study was to 
      reveal the risk factors for the severity of DR in individuals with T2DM. 
      Demographic data and biochemical parameters were collected and analyzed. METHODS: 
      A total of 518 individuals with type 2 diabetes were included. These individuals 
      were classified into three groups according to the severity of diabetic 
      retinopathy: non-diabetic retinopathy (NDR) group (N = 172), non proliferative 
      diabetic retinopathy (NPDR) group (N = 184), and proliferative diabetic 
      retinopathy (PDR) group (N = 162). Demographic and clinical measurement data of 
      the individuals were collected by reviewing medical records and direct interview. 
      The demographic data and biochemical parameters between groups were compared 
      using Student's t-test. Moreover, the factors related to severity of diabetic 
      retinopathy were identified by using the multivariate logistic regression 
      analysis. RESULTS: No significant difference in age, gender, body mass index 
      (BMI), and diabetes duration was found among these three groups. The serum uric 
      acid (SUA), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), 
      homocysteine, and urinary albumin levels were significantly higher in the NPDR 
      and PDR group than those in the NDR group (P < 0.05). The individuals in the PDR 
      group had obviously higher levels of SUA, homocysteine, and urinary albumin than 
      individuals in the NPDR group (P < 0.05). The multivariate logistic regression 
      analysis revealed that high SUA, homocysteine, TC, LDL-c, and urinary albumin 
      levels were associated with more serious diabetic retinopathy (OR > 1; P < 0.05). 
      CONCLUSION: The concentrations of SUA and urinary albumin are associated with the 
      severity of DR in individuals with T2DM.
FAU - Chen, Donghe
AU  - Chen D
AD  - Department of Endocrinology, Daqing People's Hospital, the Fifth Affiliated 
      Hospital of Harbin Medical University, No.213, Jianshe Road, Development zone, 
      Daqing, 163000, China.
FAU - Sun, Xiufang
AU  - Sun X
AD  - Department of Endocrinology, the First Affiliated Hospital of Qiqihar Medical 
      University, Qiqihar, 161041, China.
FAU - Zhao, Xinxin
AU  - Zhao X
AD  - Department of Endocrinology, the First Hospital of Suihua, No. 180 Beilin Road, 
      Beilin District, Suihua, 152000, China. 13945500835@163.com.
FAU - Liu, Ying
AU  - Liu Y
AD  - Department of Endocrinology, Daqing People's Hospital, the Fifth Affiliated 
      Hospital of Harbin Medical University, No.213, Jianshe Road, Development zone, 
      Daqing, 163000, China. daqingyingl66@163.com.
LA  - eng
PT  - Journal Article
DEP - 20201130
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
RN  - 0 (Albumins)
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Albumins
MH  - *Diabetes Mellitus, Type 2/complications
MH  - *Diabetic Retinopathy
MH  - Humans
MH  - Retrospective Studies
MH  - Uric Acid
PMC - PMC7706232
OTO - NOTNLM
OT  - Diabetic retinopathy
OT  - Serum uric acid
OT  - Type 2 diabetes mellitus
OT  - Urinary albumin
COIS- The authors declare that they have no competing interests.
EDAT- 2020/12/02 06:00
MHDA- 2021/05/15 06:00
PMCR- 2020/11/30
CRDT- 2020/12/01 05:35
PHST- 2019/12/18 00:00 [received]
PHST- 2020/11/01 00:00 [accepted]
PHST- 2020/12/01 05:35 [entrez]
PHST- 2020/12/02 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/11/30 00:00 [pmc-release]
AID - 10.1186/s12886-020-01713-5 [pii]
AID - 1713 [pii]
AID - 10.1186/s12886-020-01713-5 [doi]
PST - epublish
SO  - BMC Ophthalmol. 2020 Nov 30;20(1):467. doi: 10.1186/s12886-020-01713-5.