PMID- 33256875
OWN - NLM
STAT- MEDLINE
DCOM- 20211215
LR  - 20221207
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 126
IP  - 6
DP  - 2021 Sep 28
TI  - Trends and influencing factors of plasma folate levels in Chinese women at 
      mid-pregnancy, late pregnancy and lactation periods.
PG  - 885-891
LID - 10.1017/S0007114520004821 [doi]
AB  - Folate status for women during early pregnancy has been investigated, but data 
      for women during mid-pregnancy, late pregnancy or lactation are sparse or 
      lacking. Between May and July 2014, we conducted a cross-sectional study in 1211 
      pregnant and lactating women from three representative regions in China. 
      Approximately 135 women were enrolled in each stratum by physiological periods 
      (mid-pregnancy, late pregnancy or lactation) and regions (south, central or 
      north). Plasma folate concentrations were measured by microbiological assay. The 
      adjusted medians of folate concentration decreased from 28.8 (interquartile range 
      (IQR) 19.9, 38.2) nmol/l in mid-pregnancy to 18.6 (IQR 13.2, 26.4) nmol/l in late 
      pregnancy, and to 17.0 (IQR 12.3, 22.5) nmol/l in lactation (Pfor trend < 0.001). 
      Overall, lower folate concentrations were more likely to be observed in women 
      residing in the northern region, with younger age, higher pre-pregnancy BMI, 
      lower education or multiparity, and in lactating women who had undergone a 
      Caesarean delivery or who were breastfeeding exclusively. In total, 380 (31.4 %) 
      women had a suboptimal folate status (folate concentration <13.5 nmol/l). Women 
      in late pregnancy and lactating, residing in the northern region, having 
      multiparity and low education level had a higher risk of suboptimal folate 
      status, while those with older age had a lower risk. In conclusion, maternal 
      plasma folate concentrations decreased as pregnancy progressed, and were 
      influenced by geographic region and maternal socio-demographic characteristics. 
      Future studies are warranted to assess the necessity of folic acid 
      supplementation during later pregnancy and lactation especially for women at a 
      higher risk of folate depletion.
FAU - Zhou, Yu-Bo
AU  - Zhou YB
AD  - Institute of Reproductive and Child Health/National Health Commission Key 
      Laboratory of Reproductive Health, Peking University Health Science Center, 
      Beijing100191, People's Republic of China.
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing100191, People's Republic of China.
FAU - Si, Ke-Yi
AU  - Si KY
AD  - Institute of Reproductive and Child Health/National Health Commission Key 
      Laboratory of Reproductive Health, Peking University Health Science Center, 
      Beijing100191, People's Republic of China.
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing100191, People's Republic of China.
FAU - Li, Hong-Tian
AU  - Li HT
AD  - Institute of Reproductive and Child Health/National Health Commission Key 
      Laboratory of Reproductive Health, Peking University Health Science Center, 
      Beijing100191, People's Republic of China.
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing100191, People's Republic of China.
FAU - Li, Xiu-Cui
AU  - Li XC
AD  - Institute of Reproductive and Child Health/National Health Commission Key 
      Laboratory of Reproductive Health, Peking University Health Science Center, 
      Beijing100191, People's Republic of China.
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing100191, People's Republic of China.
FAU - Meng, Ying
AU  - Meng Y
AD  - Institute of Reproductive and Child Health/National Health Commission Key 
      Laboratory of Reproductive Health, Peking University Health Science Center, 
      Beijing100191, People's Republic of China.
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing100191, People's Republic of China.
FAU - Liu, Jian-Meng
AU  - Liu JM
AUID- ORCID: 0000-0002-3220-6084
AD  - Institute of Reproductive and Child Health/National Health Commission Key 
      Laboratory of Reproductive Health, Peking University Health Science Center, 
      Beijing100191, People's Republic of China.
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing100191, People's Republic of China.
AD  - Center for Intelligent Public Health, Institute for Artificial Intelligence, 
      Peking University, Beijing100191, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201201
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Asian People
MH  - Breast Feeding
MH  - China
MH  - Cross-Sectional Studies
MH  - Female
MH  - Folic Acid/*blood
MH  - Geography
MH  - Humans
MH  - *Lactation
MH  - *Nutritional Status
MH  - *Pregnancy
MH  - Risk Factors
MH  - Sociodemographic Factors
OTO - NOTNLM
OT  - China
OT  - Influencing factors
OT  - Lactation
OT  - Late pregnancy
OT  - Mid-pregnancy
OT  - Plasma folate
EDAT- 2020/12/02 06:00
MHDA- 2021/12/16 06:00
CRDT- 2020/12/01 05:37
PHST- 2020/12/02 06:00 [pubmed]
PHST- 2021/12/16 06:00 [medline]
PHST- 2020/12/01 05:37 [entrez]
AID - S0007114520004821 [pii]
AID - 10.1017/S0007114520004821 [doi]
PST - ppublish
SO  - Br J Nutr. 2021 Sep 28;126(6):885-891. doi: 10.1017/S0007114520004821. Epub 2020 
      Dec 1.