PMID- 33257077
OWN - NLM
STAT- MEDLINE
DCOM- 20210101
LR  - 20210101
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 756
DP  - 2021 Feb 20
TI  - Association between urinary organophosphate flame retardant diesters and steroid 
      hormones: A metabolomic study on type 2 diabetes mellitus cases and controls.
PG  - 143836
LID - S0048-9697(20)37367-8 [pii]
LID - 10.1016/j.scitotenv.2020.143836 [doi]
AB  - Metabolomic analysis was conducted by collecting urine samples from 128 
      participants in diagnose of type 2 diabetes mellitus (T2DM) and 105 volunteers in 
      healthy condition, in order to identify biomarkers of experimental populations. 
      The urinary concentrations of organophosphate flame retardant (OPFR) diesters 
      were determined and linear regression model was used to find associations between 
      OPFR diesters and the identified biomarkers. The urinary concentrations of OPFR 
      diesters ranged from 0.17-779 mug/g creatinine. Diphenyl phosphate (DPHP) was 
      detected with the highest frequency of 97% at a median level of 1.21 mug/g, and 
      bis(1-chloro-2-propyl) phosphate (BCIPP) dominated the highest median level at 
      4.24 mug/g with a detection frequency of 94.4%. As compared with the control, the 
      urinary median concentrations of bis(2-butoxyethyl) phosphate (BBOEP), 
      bis(1,3-dichloro-2-propyl) phosphate (BDCPP) and DPHP were 2.76, 2.48, and 1.46 
      times higher in people with T2DM, respectively. Urinary metabolomic data revealed 
      that steroid synthesis was the most significantly altered metabolic pathway 
      between the case and control population. Two biomarkers of cortisol and cortisone 
      that play an important role in steroid hormone regulation were quantified. The 
      linear regression model indicated that per-quartile range increase in the 
      concentrations of each OPFR diester was associated 18%-41% increase in the 
      concentrations of cortisol and cortisone, which may impact energy metabolism 
      linked with T2DM. To our knowledge, this study for the first time reported the 
      altered levels of steroid hormones associated with urinary OPFR diesters.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Ji, Yan
AU  - Ji Y
AD  - MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of 
      Environmental Science and Engineering, Nankai University, Tianjin, China; State 
      Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, 
      Hong Kong Baptist University, Hong Kong, China.
FAU - Yao, Yiming
AU  - Yao Y
AD  - MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of 
      Environmental Science and Engineering, Nankai University, Tianjin, China. 
      Electronic address: yimingyao@nankai.edu.cn.
FAU - Duan, Yishuang
AU  - Duan Y
AD  - Institute of Environment and Health, Jianghan University, Wuhan, China.
FAU - Zhao, Hongzhi
AU  - Zhao H
AD  - MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of 
      Environmental Science and Engineering, Nankai University, Tianjin, China.
FAU - Hong, Yanjun
AU  - Hong Y
AD  - State Key Laboratory of Environmental and Biological Analysis, Department of 
      Chemistry, Hong Kong Baptist University, Hong Kong, China.
FAU - Cai, Zongwei
AU  - Cai Z
AD  - State Key Laboratory of Environmental and Biological Analysis, Department of 
      Chemistry, Hong Kong Baptist University, Hong Kong, China.
FAU - Sun, Hongwen
AU  - Sun H
AD  - MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of 
      Environmental Science and Engineering, Nankai University, Tianjin, China.
LA  - eng
PT  - Journal Article
DEP - 20201120
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Flame Retardants)
RN  - 0 (Hormones)
RN  - 0 (Organophosphates)
RN  - 0 (Steroids)
SB  - IM
MH  - *Diabetes Mellitus, Type 2
MH  - *Flame Retardants
MH  - Hormones
MH  - Humans
MH  - Organophosphates
MH  - Steroids
OTO - NOTNLM
OT  - Cortisol
OT  - Metabolomics
OT  - Organophosphate flame retardant diesters
OT  - Steroid synthesis
OT  - Type 2 diabetes mellitus
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/12/02 06:00
MHDA- 2021/01/02 06:00
CRDT- 2020/12/01 05:43
PHST- 2020/08/31 00:00 [received]
PHST- 2020/10/22 00:00 [revised]
PHST- 2020/11/03 00:00 [accepted]
PHST- 2020/12/02 06:00 [pubmed]
PHST- 2021/01/02 06:00 [medline]
PHST- 2020/12/01 05:43 [entrez]
AID - S0048-9697(20)37367-8 [pii]
AID - 10.1016/j.scitotenv.2020.143836 [doi]
PST - ppublish
SO  - Sci Total Environ. 2021 Feb 20;756:143836. doi: 10.1016/j.scitotenv.2020.143836. 
      Epub 2020 Nov 20.