PMID- 33258291
OWN - NLM
STAT- MEDLINE
DCOM- 20220322
LR  - 20220322
IS  - 2157-6580 (Electronic)
IS  - 2157-6564 (Print)
IS  - 2157-6564 (Linking)
VI  - 10
IP  - 4
DP  - 2021 Apr
TI  - Reemergence of neural crest stem cell-like states in melanoma during disease 
      progression and treatment.
PG  - 522-533
LID - 10.1002/sctm.20-0351 [doi]
AB  - Melanoma is the deadliest of all skin cancers due to its high metastatic 
      potential. In recent years, advances in targeted therapy and immunotherapy have 
      contributed to a remarkable progress in the treatment of metastatic disease. 
      However, intrinsic or acquired resistance to such therapies remains a major 
      obstacle in melanoma treatment. Melanoma disease progression, beginning from 
      tumor initiation and growth to acquisition of invasive phenotypes and metastatic 
      spread and acquisition of treatment resistance, has been associated with cellular 
      dedifferentiation and the hijacking of gene regulatory networks reminiscent of 
      the neural crest (NC)-the developmental structure which gives rise to melanocytes 
      and hence melanoma. This review summarizes the experimental evidence for the 
      involvement of NC stem cell (NCSC)-like cell states during melanoma progression 
      and addresses novel approaches to combat the emergence of stemness 
      characteristics that have shown to be linked with aggressive disease outcome and 
      drug resistance.
CI  - (c) 2020 The Authors. STEM CELLS TRANSLATIONAL MEDICINE published by Wiley 
      Periodicals LLC on behalf of AlphaMed Press.
FAU - Diener, Johanna
AU  - Diener J
AUID- ORCID: 0000-0002-7733-5904
AD  - University of Zurich, Institute of Anatomy, Zurich, Switzerland.
FAU - Sommer, Lukas
AU  - Sommer L
AUID- ORCID: 0000-0002-1143-7908
AD  - University of Zurich, Institute of Anatomy, Zurich, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201201
PL  - England
TA  - Stem Cells Transl Med
JT  - Stem cells translational medicine
JID - 101578022
SB  - IM
MH  - Disease Progression
MH  - Drug Resistance, Neoplasm
MH  - Humans
MH  - Melanocytes
MH  - *Melanoma/pathology/therapy
MH  - *Neural Crest/cytology
MH  - *Neural Stem Cells
PMC - PMC7980219
OTO - NOTNLM
OT  - cancer
OT  - development
OT  - drug resistance
OT  - invasion
OT  - melanoma
OT  - neural crest stem cells (NCSCs)
OT  - tumor initiation
COIS- The authors declared no potential conflicts of interest.
EDAT- 2020/12/02 06:00
MHDA- 2022/03/23 06:00
PMCR- 2020/12/01
CRDT- 2020/12/01 06:05
PHST- 2020/10/28 00:00 [revised]
PHST- 2020/07/28 00:00 [received]
PHST- 2020/11/04 00:00 [accepted]
PHST- 2020/12/02 06:00 [pubmed]
PHST- 2022/03/23 06:00 [medline]
PHST- 2020/12/01 06:05 [entrez]
PHST- 2020/12/01 00:00 [pmc-release]
AID - SCT312873 [pii]
AID - 10.1002/sctm.20-0351 [doi]
PST - ppublish
SO  - Stem Cells Transl Med. 2021 Apr;10(4):522-533. doi: 10.1002/sctm.20-0351. Epub 
      2020 Dec 1.