PMID- 33258398
OWN - NLM
STAT- MEDLINE
DCOM- 20220504
LR  - 20220504
IS  - 1563-5244 (Electronic)
IS  - 0883-0185 (Linking)
VI  - 41
IP  - 2
DP  - 2022
TI  - A comprehensive overview on the genetics of Behcet's disease.
PG  - 84-106
LID - 10.1080/08830185.2020.1851372 [doi]
AB  - Behcet's disease (BD) is a systemic and inflammatory disease, characterized 
      mainly by recurrent oral and genital ulcers, eye involvement, and skin lesions. 
      Although the exact etiopathogenesis of BD remains unrevealed, a bulk of studies 
      have implicated the genetic contributing factors as critical players in disease 
      predisposition. In countries along the Silk Road, human leukocyte antigen 
      (HLA)-B51 has been reported as the strongest genetically associated factor for 
      BD. Genome-wide association studies, local genetic polymorphism studies, and 
      meta-analysis of combined data from Turkish, Iranian, and Japanese populations 
      have also identified new genetic associations with BD. Among these, other HLA 
      alleles such as HLA-B*15, HLA-B*27, HLA-B*57, and HLA-A*26 have been found as 
      independent risk factors for BD, whereas HLA-B*49 and HLA-A*03 are independent 
      protective alleles for BD. Moreover, other genes have also reached the 
      genome-wide significance level of association with BD susceptibility, including 
      IL10, IL23R-IL12RB2, IL12A, CCR1-CCR3, STAT4, TNFAIP3, ERAP1, KLRC4, and FUT2. 
      Also, several rare nonsynonymous variants in TLR4, IL23R, NOD2, and MEFV genes 
      have been reported to be involved in BD pathogenesis. According to genetic 
      determinants in the loci outside the MHC region that are contributed to the host 
      defense, immunity, and inflammation pathways, it is suggested that immune 
      responses to the pathogen as an important environmental factor and mucosal 
      immunity contribute to BD susceptibility.
FAU - Mahmoudi, Mahdi
AU  - Mahmoudi M
AUID- ORCID: 0000-0002-8164-8831
AD  - Department of Immunology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran.
AD  - Inflammation Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran.
FAU - Aslani, Saeed
AU  - Aslani S
AD  - Department of Immunology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Meguro, Akira
AU  - Meguro A
AD  - Department of Ophthalmology and Visual Science, Yokohama City University Graduate 
      School of Medicine, Yokohama, Japan.
FAU - Akhtari, Maryam
AU  - Akhtari M
AD  - Department of Immunology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran.
AD  - Inflammation Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran.
FAU - Fatahi, Yousef
AU  - Fatahi Y
AD  - Faculty of Pharmacy, Department of Pharmaceutical Nanotechnology, Tehran 
      University of Medical Sciences, Tehran, Iran.
AD  - Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Mizuki, Nobuhisa
AU  - Mizuki N
AD  - Department of Ophthalmology and Visual Science, Yokohama City University Graduate 
      School of Medicine, Yokohama, Japan.
FAU - Shahram, Farhad
AU  - Shahram F
AD  - Department of Immunology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20201201
PL  - England
TA  - Int Rev Immunol
JT  - International reviews of immunology
JID - 8712260
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B51 Antigen)
RN  - 0 (MEFV protein, human)
RN  - 0 (Minor Histocompatibility Antigens)
RN  - 0 (Pyrin)
RN  - EC 3.4.11.- (Aminopeptidases)
RN  - EC 3.4.11.- (ERAP1 protein, human)
SB  - IM
MH  - Aminopeptidases/genetics
MH  - *Behcet Syndrome/genetics
MH  - Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-B51 Antigen/genetics
MH  - Humans
MH  - Iran
MH  - Minor Histocompatibility Antigens
MH  - Pyrin/genetics
OTO - NOTNLM
OT  - Behcet's disease
OT  - GWAS
OT  - Genetic association
OT  - Inflammation
EDAT- 2020/12/02 06:00
MHDA- 2022/05/06 06:00
CRDT- 2020/12/01 08:36
PHST- 2020/12/02 06:00 [pubmed]
PHST- 2022/05/06 06:00 [medline]
PHST- 2020/12/01 08:36 [entrez]
AID - 10.1080/08830185.2020.1851372 [doi]
PST - ppublish
SO  - Int Rev Immunol. 2022;41(2):84-106. doi: 10.1080/08830185.2020.1851372. Epub 2020 
      Dec 1.