PMID- 33258594
OWN - NLM
STAT- MEDLINE
DCOM- 20210305
LR  - 20210305
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 54
IP  - 24
DP  - 2020 Dec 15
TI  - Effects of In Utero Exposure to Perfluorooctane Sulfonate on Placental Functions.
PG  - 16050-16061
LID - 10.1021/acs.est.0c06569 [doi]
AB  - Perfluorooctane sulfonate (PFOS) is a metabolic-disrupting chemical. There is a 
      strong association between maternal and cord blood PFOS concentrations, affecting 
      metabolism in early life. However, the underlying effects have not been fully 
      elucidated. In this study, using the maternal-fetal model, we investigated the 
      impact of gestational PFOS exposure on the placental structure and nutrient 
      transport. Pregnant mice were oral gavaged with PFOS (1 or 3 mug PFOS/g body 
      weight) from gestational day (GD) 4.5 until GD 17.5. Our data showed a 
      significant reduction in fetal body weight at high dose exposure. There were no 
      noticeable changes in placental weights and the relative areas of junctional and 
      labyrinth zones among the control and exposed groups. However, a placental 
      nutrient transport assay showed a significant reduction in maternal-fetal 
      transport of the glucose and amino acid analogues. Western blot analysis showed a 
      significant decrease in the expression levels of placental SNAT4 upon PFOS 
      exposure. Moreover, in the high-dose exposed group, placenta and fetal livers 
      were found to have significantly higher corticosterone levels, a negative 
      regulator of fetal growth. The perturbation in the placental transport function 
      and corticosterone levels accounted for the PFOS-induced reduction of fetal body 
      weights.
FAU - Wan, Hin Ting
AU  - Wan HT
AD  - Croucher Institute for Environmental Sciences, Department of Biology, Hong Kong 
      Baptist University, Kowloon, Hong Kong SAR, China.
FAU - Wong, Aman Yi-Man
AU  - Wong AY
AD  - Croucher Institute for Environmental Sciences, Department of Biology, Hong Kong 
      Baptist University, Kowloon, Hong Kong SAR, China.
FAU - Feng, Shi
AU  - Feng S
AD  - Croucher Institute for Environmental Sciences, Department of Biology, Hong Kong 
      Baptist University, Kowloon, Hong Kong SAR, China.
FAU - Wong, Chris Kong-Chu
AU  - Wong CK
AUID- ORCID: 0000-0001-5449-5836
AD  - Croucher Institute for Environmental Sciences, Department of Biology, Hong Kong 
      Baptist University, Kowloon, Hong Kong SAR, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201201
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Fluorocarbons)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
SB  - IM
MH  - *Alkanesulfonic Acids/toxicity
MH  - Animals
MH  - Female
MH  - Fetal Weight
MH  - *Fluorocarbons/toxicity
MH  - Humans
MH  - Maternal Exposure/adverse effects
MH  - Mice
MH  - Placenta
MH  - Pregnancy
EDAT- 2020/12/02 06:00
MHDA- 2021/03/06 06:00
CRDT- 2020/12/01 12:26
PHST- 2020/12/02 06:00 [pubmed]
PHST- 2021/03/06 06:00 [medline]
PHST- 2020/12/01 12:26 [entrez]
AID - 10.1021/acs.est.0c06569 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2020 Dec 15;54(24):16050-16061. doi: 
      10.1021/acs.est.0c06569. Epub 2020 Dec 1.