PMID- 33259121
OWN - NLM
STAT- MEDLINE
DCOM- 20220117
LR  - 20220117
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Print)
IS  - 1399-543X (Linking)
VI  - 22
IP  - 3
DP  - 2021 May
TI  - Celiac disease can be predicted by high levels of tissue transglutaminase 
      antibodies in children and adolescents with type 1 diabetes.
PG  - 417-424
LID - 10.1111/pedi.13165 [doi]
AB  - OBJECTIVES: Children with type 1 diabetes (T1D) are not included in guidelines 
      regarding diagnosis criteria for celiac disease (CD) without a diagnostic biopsy, 
      due to lack of data. We explored whether tissue transglutaminase antibodies 
      (anti-tTG) that were >/= 10 times the upper limit of normal (10x ULN) predicted CD 
      in T1D. METHODS: Data from the Swedish prospective Better Diabetes Diagnosis 
      study was used, and 2035 children and adolescents with T1D diagnosed between 
      2005-2010 were included. Of these, 32 had been diagnosed with CD before T1D. The 
      children without CD were repeatedly screened for CD using anti-tTG antibodies of 
      immunoglobulin type A. In addition, their human leukocyte antigen (HLA) were 
      genotyped. All children with positive anti-tTG were advised to undergo biopsy. 
      Biopsies were performed on 119 children and graded using the Marsh-Oberhuber 
      classification. RESULTS: All of the 60 children with anti-tTG >/=10x ULN had CD 
      verified by biopsies. The degree of mucosal damage correlated with anti-tTG 
      levels. Among 2003 screened children, 6.9% had positive anti-tTG and 5.6% were 
      confirmed CD. The overall CD prevalence, when including the 32 children with CD 
      before T1D, was 7.0% (145/2035). All but one of the children diagnosed with CD 
      had HLA-DQ2 and/or DQ8. CONCLUSIONS: As all screened children and adolescents 
      with T1D with tissue transglutaminase antibodies above 10 times the positive 
      value 10x ULN had CD, we propose that the guidelines for diagnosing CD in 
      screened children, when biopsies can be omitted, should also apply to children 
      and adolescents with T1D as a noninvasive method.
CI  - (c) 2020 The Authors. Pediatric Diabetes published by John Wiley & Sons Ltd.
FAU - Cerqueiro Bybrant, Mara
AU  - Cerqueiro Bybrant M
AUID- ORCID: 0000-0002-2560-0569
AD  - Pediatric Endocrinology Unit, Department of Women's and Children's Health, 
      Karolinska Institutet, Stockholm, Sweden.
FAU - Uden, Elin
AU  - Uden E
AD  - Lund University, Lund, Sweden.
FAU - Frederiksen, Filippa
AU  - Frederiksen F
AD  - Karolinska Institutet, Stockholm, Sweden.
FAU - Gustafsson, Anna L
AU  - Gustafsson AL
AD  - Children Clinic, Halland's Hospital, Halmstad, Sweden.
FAU - Arvidsson, Carl-Goran
AU  - Arvidsson CG
AD  - Department of Pediatrics, Vastmanland's Hospital, Vasteras, Sweden.
FAU - Fureman, Anna-Lena
AU  - Fureman AL
AD  - Children's clinic, Ostersund Hospital, Sweden.
FAU - Forsander, Gun
AU  - Forsander G
AUID- ORCID: 0000-0002-0266-9651
AD  - Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, 
      University of Gothenburg, Gothenburg, Sweden.
AD  - Department of Pediatrics, Queen Silvia Children's Hospital, Sahlgrenska 
      University Hospital, Gothenburg, Sweden.
FAU - Elding Larsson, Helena
AU  - Elding Larsson H
AUID- ORCID: 0000-0003-3306-1742
AD  - Department of Clinical Sciences, Lund University/Clinical Research Centre, Skane 
      University Hospital, Malmo, Sweden.
FAU - Ivarsson, Sten A
AU  - Ivarsson SA
AD  - Department of Clinical Sciences, Lund University, Skane University Hospital, 
      Pediatrics, Lund, Sweden.
FAU - Lindgren, Marie
AU  - Lindgren M
AD  - Department of Clinical Sciences, Lund University, Skane University Hospital, 
      Pediatrics, Lund, Sweden.
AD  - Children's Clinic, Vrinnevi hospital, Norrkoping, Sweden.
FAU - Ludvigsson, Johnny
AU  - Ludvigsson J
AD  - Crown Princess Victoria's Children's and Youth Hospital, University Hospital, 
      Linkoping, Sweden.
AD  - Division of Pediatrics, Department of Clinical and Experimental Medicine, 
      Linkoping University, Linkoping, Sweden.
FAU - Marcus, Claude
AU  - Marcus C
AD  - Division of Pediatrics, Department of Clinical Science Intervention and 
      Technology, Karolinska Institute, Stockholm, Sweden.
FAU - Pundziute Lycka, Auste
AU  - Pundziute Lycka A
AD  - Department of Pediatrics, Queen Silvia Children's Hospital, Sahlgrenska 
      University Hospital, Gothenburg, Sweden.
FAU - Persson, Martina
AU  - Persson M
AUID- ORCID: 0000-0003-2268-3159
AD  - Department of Medicine, Clinical Epidemiology, Karolinska University Hospital, 
      Stockholm, Sweden.
FAU - Samuelsson, Ulf
AU  - Samuelsson U
AUID- ORCID: 0000-0002-2837-4237
AD  - Crown Princess Victoria's Children's and Youth Hospital, University Hospital, 
      Linkoping, Sweden.
AD  - Division of Pediatrics, Department of Clinical and Experimental Medicine, 
      Linkoping University, Linkoping, Sweden.
FAU - Sarnblad, Stefan
AU  - Sarnblad S
AUID- ORCID: 0000-0002-1440-9961
AD  - School of Medical Sciences, Orebro University, Orebro, Sweden.
FAU - Akesson, Karin
AU  - Akesson K
AD  - Department of Pediatrics, Ryhov County Hospital, Jonkoping, Sweden.
AD  - Jonkoping Academy for Improvement of Health and Welfare, Jonkoping University, 
      Jonkoping, Sweden.
FAU - Ortqvist, Eva
AU  - Ortqvist E
AUID- ORCID: 0000-0002-6924-704X
AD  - Pediatric Endocrinology Unit, Department of Women's and Children's Health, 
      Karolinska Institutet, Stockholm, Sweden.
FAU - Carlsson, Annelie
AU  - Carlsson A
AUID- ORCID: 0000-0003-2361-7743
AD  - Department of Clinical Sciences, Lund University, Skane University Hospital, 
      Pediatrics, Lund, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201212
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (Autoantibodies)
RN  - 0 (anti-transglutaminase autoantibody)
RN  - EC 2.3.2.13 (Transglutaminases)
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Autoantibodies/*blood
MH  - Celiac Disease/*blood/*diagnosis/etiology
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 1/*blood/*complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Predictive Value of Tests
MH  - Sweden
MH  - Transglutaminases/*immunology
PMC - PMC8048786
OTO - NOTNLM
OT  - biopsy
OT  - celiac disease
OT  - screening
OT  - tissue transglutaminase antibodies
OT  - type 1 diabetes
EDAT- 2020/12/02 06:00
MHDA- 2022/01/18 06:00
PMCR- 2021/04/15
CRDT- 2020/12/01 12:46
PHST- 2020/09/24 00:00 [revised]
PHST- 2020/07/21 00:00 [received]
PHST- 2020/11/11 00:00 [accepted]
PHST- 2020/12/02 06:00 [pubmed]
PHST- 2022/01/18 06:00 [medline]
PHST- 2020/12/01 12:46 [entrez]
PHST- 2021/04/15 00:00 [pmc-release]
AID - PEDI13165 [pii]
AID - 10.1111/pedi.13165 [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2021 May;22(3):417-424. doi: 10.1111/pedi.13165. Epub 2020 Dec 
      12.