PMID- 33259256
OWN - NLM
STAT- MEDLINE
DCOM- 20211210
LR  - 20211214
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 46
IP  - 4
DP  - 2021 Apr
TI  - Influences of Hypomagnesemia on Optic Nerve and Retinal Vascular Structure 
      Determined Using Optical Coherence Tomography (OCT) Angiography.
PG  - 579-584
LID - 10.1080/02713683.2020.1857779 [doi]
AB  - Purpose: To evaluate the effects of low blood magnesium levels on the optic 
      nerve, retina, and retinal vascular structure.Methods: This observational and 
      cross-sectional study was conducted between June 2019 and May 2020 with 
      participants aged 20-39 years, who had a visual acuity of >/=20/20, the axial 
      length of 22-24.5 mm, refractive defect spherical equivalent of </=+/-3D, and 
      intraocular pressure of </=21 mm Hg. All participants had a complaint of twitching 
      in their eyes. The participants with normal serum magnesium levels constituted 
      the control group, and patients with hypomagnesemia constituted the patient 
      group. Updated AngioScan software (Navis ver. 1.8.0.) of Nidek's RS-3000 Advance 
      system was used to analyze the spectral domain-optical coherence tomography 
      (SD-OCT) and optical coherence tomography-angiography (OCT-A) images.Results: A 
      total of 100 right eyes of 100 individuals was included in the study. The mean 
      retinal nerve fiber layer (RNFL) thickness was 108.52 +/- 12.46 mum in the control 
      group, and 97.3 +/- 9.7 mum in the hypomagnesemia group (P < .001). In the control 
      group, the global superficial capillary plexus (SCP) and deep capillary plexus 
      (DCP) vessel densities (VDs) were 41.92 +/- 2.29, and 37.54 +/- 3.83, respectively. 
      In the patient group, the global SCP and DCP VDs were 37.66 +/- 3.14, and 
      32.95 +/- 5.57, respectively. The SCP and DCP VD percentages were significantly 
      lower in the patient group. The mean foveal avascular zone (FAZ) area, perimeter 
      and circularity index (CI) were 0.32 +/- 0.13 mm(2), 2.89 +/- 0.59 mm, and 
      0.52 +/- 0.09, respectively, for the control group and 0.38 +/- 0.11 mm(2), 
      2.99 +/- 0.64 mm, and 0.38 +/- 0.1, respectively, for the patient group. The FAZ area 
      and perimeter were significantly higher (P = .013 and P = .001) and FAZ CI was 
      significantly lower (P < .001) in the patients with hypomagnesemia.Conclusion: 
      Our study revealed that OCT and OCT-A measurements may be used in the 
      determination of the optic nerve and retinal vascular structure changes in 
      hypomagnesemia.
FAU - Ugurlu, Adem
AU  - Ugurlu A
AUID- ORCID: 0000-0002-8900-7043
AD  - Department of Ophthalmology, Faculty of Medicine, Erzincan Binali Yildirim 
      University, Erzincan, Turkey.
FAU - Yilmaz, Hayati
AU  - Yilmaz H
AD  - Department of Ophthalmology, Health Science University Umraniye Training and 
      Research Hospital, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20201217
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Intraocular Pressure/physiology
MH  - Magnesium/*blood
MH  - Magnesium Deficiency/diagnostic imaging/*pathology
MH  - Male
MH  - Nerve Fibers/*pathology
MH  - Optic Nerve/diagnostic imaging/*pathology
MH  - Retinal Ganglion Cells/*pathology
MH  - Retinal Vessels/diagnostic imaging/*pathology
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
MH  - Young Adult
OTO - NOTNLM
OT  - Hypomagnesemia
OT  - angiography
OT  - optic nerve
OT  - optical coherence tomography
OT  - retina
EDAT- 2020/12/02 06:00
MHDA- 2021/12/15 06:00
CRDT- 2020/12/01 17:08
PHST- 2020/12/02 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2020/12/01 17:08 [entrez]
AID - 10.1080/02713683.2020.1857779 [doi]
PST - ppublish
SO  - Curr Eye Res. 2021 Apr;46(4):579-584. doi: 10.1080/02713683.2020.1857779. Epub 
      2020 Dec 17.