PMID- 33259972
OWN - NLM
STAT- MEDLINE
DCOM- 20210705
LR  - 20210705
IS  - 1878-8769 (Electronic)
IS  - 1878-8750 (Linking)
VI  - 146
DP  - 2021 Feb
TI  - Variation of Minimum Clinically Important Difference by Age, Gender, Baseline 
      Disability, and Change of Direction in Adult Spinal Deformity Population: Is It a 
      Constant Value?
PG  - e1171-e1176
LID - S1878-8750(20)32509-2 [pii]
LID - 10.1016/j.wneu.2020.11.124 [doi]
AB  - BACKGROUND: The minimum clinically important difference (MCID), an important 
      concept to evaluate the effectiveness of treatments, might not be a single 
      "magical" constant for any given health-related quality of life (HRQoL) scale. 
      Thus, we analyzed the effects of various factors on MCIDs for several HRQoL 
      measures in an adult spinal deformity population. METHODS: Surgical and 
      nonsurgical patients from a multicenter adult spinal deformity database who had 
      completed pretreatment and 1-year follow-up questionnaires (Core Outcome Measures 
      Index [COMI], Oswestry Disability Index [ODI], Medical Outcomes Study 36-item 
      short-form questionnaire, 22-item Scoliosis Research Society Outcomes 
      questionnaire, and an anchor question of "back health"-related change during the 
      previous year) were evaluated. The MCIDs for each HRQoL measure were calculated 
      using an anchor-based method and latent class analysis for the overall population 
      and subpopulations stratified by age, gender, and baseline scores (ODI and COMI) 
      separately for patients with positive versus negative perceptions of change. 
      RESULTS: Patients with a baseline ODI score of <20, 20-40, and >40 had an MCID of 
      2.24, 11.35, and 26.57, respectively. Similarly, patients with a baseline COMI 
      score of <2.75, 2.8-5.4, and >5.4 had an MCID of 0.59, 1.38, and 3.67 
      respectively. The overall MCID thresholds for deterioration and improvement were 
      0.27 and 2.62 for COMI, 2.23 and 14.31 for ODI, and 0.01 and 0.71 for 22-item 
      Scoliosis Research Society Outcomes questionnaire, respectively. CONCLUSIONS: The 
      results from the present study have demonstrated that MCIDs change in accordance 
      with the baseline scores and direction of change but not by age or gender. The 
      MCID, in its current state, should be considered a concept rather than a 
      constant.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Bahadir, Sinan
AU  - Bahadir S
AD  - ARTES Spine Center, Acibadem Ankara Hospital, Ankara, Turkey.
FAU - Yuksel, Selcen
AU  - Yuksel S
AD  - Department of Biostatistics, Yildirim Beyazit University, Ankara, Turkey.
FAU - Ayhan, Selim
AU  - Ayhan S
AD  - ARTES Spine Center, Acibadem Ankara Hospital, Ankara, Turkey.
FAU - Nabi, Vugar
AU  - Nabi V
AD  - ARTES Spine Center, Acibadem Ankara Hospital, Ankara, Turkey.
FAU - Vila-Casademunt, Alba
AU  - Vila-Casademunt A
AD  - Department of Orthopedic Surgery, Hospital Universitari Vall d'Hebron, Barcelona, 
      Spain.
FAU - Obeid, Ibrahim
AU  - Obeid I
AD  - Department of Orthopedic Surgery, Bordeaux University Hospital, Bordeaux, France.
FAU - Sanchez Perez-Grueso, Francisco Javier
AU  - Sanchez Perez-Grueso FJ
AD  - Department of Orthopedic Surgery, Hospital Universitari La Paz, Madrid, Spain.
FAU - Acaroglu, Emre
AU  - Acaroglu E
AD  - Department of Orthopedic Surgery, Ankara Spine Center, Ankara, Turkey. Electronic 
      address: acaroglue@gmail.com.
CN  - European Spine Study Group
AD  - Department of Orthopedic Surgery, Hospital Universitari Vall d'Hebron, Barcelona, 
      Spain.
LA  - eng
PT  - Journal Article
DEP - 20201128
PL  - United States
TA  - World Neurosurg
JT  - World neurosurgery
JID - 101528275
RN  - 0 (Analgesics)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Analgesics/therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - *Quality of Life
MH  - Sex Factors
MH  - Spinal Curvatures/*physiopathology/therapy
MH  - Spinal Fusion/methods
MH  - Watchful Waiting/methods
OTO - NOTNLM
OT  - Adult spinal deformity
OT  - Health-related quality of life
OT  - Minimum clinically important difference
OT  - Outcome measures
EDAT- 2020/12/02 06:00
MHDA- 2021/07/06 06:00
CRDT- 2020/12/01 20:09
PHST- 2020/09/27 00:00 [received]
PHST- 2020/11/20 00:00 [revised]
PHST- 2020/11/21 00:00 [accepted]
PHST- 2020/12/02 06:00 [pubmed]
PHST- 2021/07/06 06:00 [medline]
PHST- 2020/12/01 20:09 [entrez]
AID - S1878-8750(20)32509-2 [pii]
AID - 10.1016/j.wneu.2020.11.124 [doi]
PST - ppublish
SO  - World Neurosurg. 2021 Feb;146:e1171-e1176. doi: 10.1016/j.wneu.2020.11.124. Epub 
      2020 Nov 28.