PMID- 33260067
OWN - NLM
STAT- MEDLINE
DCOM- 20210916
LR  - 20210916
IS  - 1873-2232 (Electronic)
IS  - 0378-4320 (Linking)
VI  - 224
DP  - 2021 Jan
TI  - Effect of eCG treatment on gene expression of selected matrix metalloproteinases 
      (MMP-2, MMP-7, MMP-9, MMP-10, and MMP-13) and the tissue inhibitors of 
      metalloproteinases (TIMP-2 and TIMP-3) in the chicken ovary.
PG  - 106666
LID - S0378-4320(20)30538-8 [pii]
LID - 10.1016/j.anireprosci.2020.106666 [doi]
AB  - Several metalloproteinases (MMPs) are present and functional in the chicken ovary 
      and regulate the extracellular matrix (ECM) during follicle development, 
      ovulation, atresia, and regression. The regulation of the abundance of MMPs in 
      avian ovarian follicles, however, is largely unknown. The aim of the present 
      study was to examine effects of equine chorionic gonadotropin (eCG) on abundance 
      of selected MMPs and relevant tissue inhibitors of MMPs (TIMPs) in the hen ovary. 
      The MMP-2 and MMP-9 activity was also determined. Results indicated there were 
      effects of eCG on abundances of MMP-2, MMP-7, MMP-9, MMP-10, MMP-13, TIMP-2, and 
      TIMP-3 mRNA transcript and/or protein relative abundances in white, yellowish, 
      small yellow, and the largest yellow preovulatory (F3-F1) ovarian follicles. The 
      response to eCG depended on the stage of follicle development, layer of 
      follicular wall, and the type of MMPs or TIMPs affected by eCG. Furthermore, 
      there was a pause in egg laying when eCG was administered and there were 
      morphological changes in the ovary following eCG treatment that were associated 
      with alterations in MMP-2 and MMP-9 activity. In general, the results indicate 
      that eCG, which has primarily follicle stimulating hormone (FSH)-like 
      bioactivities, is a negative regulator of MMP abundance and activity in the 
      largest yellow preovulatory follicles. Results from the present study indicate 
      the gonadotropins, especially FSH, by the regulation of transcription, 
      translation, and/or activity of proteins of the MMP system have effects on the 
      mechanisms that underlie ECM remodeling and cell function throughout ovarian 
      follicle development in the chicken ovary.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Wolak, Dominika
AU  - Wolak D
AD  - Department of Animal Physiology and Endocrinology, University of Agriculture in 
      Krakow, al. Mickiewicza 24/28, Krakow, 30-059, Poland.
FAU - Sechman, Andrzej
AU  - Sechman A
AD  - Department of Animal Physiology and Endocrinology, University of Agriculture in 
      Krakow, al. Mickiewicza 24/28, Krakow, 30-059, Poland.
FAU - Hrabia, Anna
AU  - Hrabia A
AD  - Department of Animal Physiology and Endocrinology, University of Agriculture in 
      Krakow, al. Mickiewicza 24/28, Krakow, 30-059, Poland. Electronic address: 
      anna.hrabia@urk.edu.pl.
LA  - eng
PT  - Journal Article
DEP - 20201126
PL  - Netherlands
TA  - Anim Reprod Sci
JT  - Animal reproduction science
JID - 7807205
RN  - 0 (Chorionic Gonadotropin)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-3)
RN  - 127497-59-0 (Tissue Inhibitor of Metalloproteinase-2)
RN  - EC 3.4.- (Metalloproteases)
RN  - EC 3.4.24.- (Matrix Metalloproteinase 13)
RN  - EC 3.4.24.22 (Matrix Metalloproteinase 10)
RN  - EC 3.4.24.23 (Matrix Metalloproteinase 7)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Animals
MH  - *Chickens
MH  - Chorionic Gonadotropin/*pharmacology
MH  - Female
MH  - Gene Expression Regulation/*drug effects
MH  - Matrix Metalloproteinase 10/genetics/metabolism
MH  - Matrix Metalloproteinase 13/genetics/metabolism
MH  - Matrix Metalloproteinase 2/genetics/metabolism
MH  - Matrix Metalloproteinase 7/genetics/metabolism
MH  - Matrix Metalloproteinase 9/genetics/metabolism
MH  - Metalloproteases/genetics/*metabolism
MH  - Ovary/*drug effects/metabolism
MH  - Tissue Inhibitor of Metalloproteinase-2/genetics/metabolism
MH  - Tissue Inhibitor of Metalloproteinase-3/genetics/metabolism
OTO - NOTNLM
OT  - Chicken
OT  - MMPs
OT  - Ovary
OT  - TIMPs
OT  - eCG
EDAT- 2020/12/02 06:00
MHDA- 2021/09/18 06:00
CRDT- 2020/12/01 20:12
PHST- 2020/09/19 00:00 [received]
PHST- 2020/11/23 00:00 [revised]
PHST- 2020/11/24 00:00 [accepted]
PHST- 2020/12/02 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2020/12/01 20:12 [entrez]
AID - S0378-4320(20)30538-8 [pii]
AID - 10.1016/j.anireprosci.2020.106666 [doi]
PST - ppublish
SO  - Anim Reprod Sci. 2021 Jan;224:106666. doi: 10.1016/j.anireprosci.2020.106666. 
      Epub 2020 Nov 26.