PMID- 33261231
OWN - NLM
STAT- MEDLINE
DCOM- 20210809
LR  - 20210809
IS  - 2327-2228 (Electronic)
IS  - 0363-7913 (Linking)
VI  - 103
IP  - 10
DP  - 2020 Dec 1
TI  - A Case of Interstitial Pneumonia with Features of Autoimmunity.
PG  - 32-34
AB  - We present a case of a 61-year-old woman with several months of gradually 
      worsening shortness of breath, requiring multiple hospitalizations with acute 
      hypoxemic respiratory failure. She was initially treated for eosinophilic 
      pneumonia presumed to be secondary to medications or rheumatoid lung without much 
      improvement. Her subsequent chest CT showed honeycombing and diffuse ground-glass 
      opacities, and she was found to have elevated rheumatoid factor (RF) and anti-CCP 
      antibody titers without extrathoracic features of rheumatoid arthritis. This 
      clinical scenario was suggestive of an interstitial lung disease (ILD) due to 
      occult underlying connective tissue disorder (CTD), along the lines of the 
      recently proposed entity interstitial pneumonia with autoimmune features (IPAF). 
      She continued to deteriorate rapidly and passed away after experiencing recurrent 
      exacerbations. As there is limited evidence to explain the clinical course of 
      such patients, there is a need for prospective research to develop tailored 
      regimens to prevent progression or even reverse the disease process.
FAU - Nahar, Richa
AU  - Nahar R
AD  - Assistant Professor of Medicine, Clinician Educator, Division of Hospital 
      Medicine, Alpert Medical School of Brown University, Providence, RI.
FAU - Jain, Sukrit
AU  - Jain S
AD  - Internal Medicine Resident, Duke University.
FAU - Carino, Gerardo
AU  - Carino G
AD  - Director of Intensive Care Unit at The Miriam Hospital, Associate Professor of 
      Medicine, Division of Pulmonary and Critical Care Medicine, Alpert Medical School 
      of Brown University, Providence, RI.
FAU - Shea, Barry S
AU  - Shea BS
AD  - Director of Interstitial Lung Disease Program, Assistant Professor of Medicine, 
      Division of Pulmonary and Critical Care Medicine, Alpert Medical School of Brown 
      University, Providence, RI.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20201201
PL  - United States
TA  - R I Med J (2013)
JT  - Rhode Island medical journal (2013)
JID - 101605827
SB  - IM
MH  - Autoimmunity
MH  - *Connective Tissue Diseases
MH  - Female
MH  - Humans
MH  - *Lung Diseases, Interstitial/diagnosis
MH  - Middle Aged
MH  - Prospective Studies
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - interstitial pneumonia with autoimmune features
OT  - undifferentiated connective tissue disorder with interstitial lung disease
EDAT- 2020/12/03 06:00
MHDA- 2021/08/10 06:00
CRDT- 2020/12/02 01:04
PHST- 2020/12/02 01:04 [entrez]
PHST- 2020/12/03 06:00 [pubmed]
PHST- 2021/08/10 06:00 [medline]
PST - epublish
SO  - R I Med J (2013). 2020 Dec 1;103(10):32-34.