PMID- 33262206
OWN - NLM
STAT- MEDLINE
DCOM- 20211102
LR  - 20211102
IS  - 1526-9906 (Electronic)
IS  - 1526-9906 (Linking)
VI  - 21
IP  - 12
DP  - 2020 Dec
TI  - Cow's Milk Protein Allergy in Term and Preterm Infants: Clinical Manifestations, 
      Immunologic Pathophysiology, and Management Strategies.
PG  - e795-e808
LID - 10.1542/neo.21-12-e795 [doi]
AB  - Cow's milk allergy is a common food allergy among infants. Symptoms of cow's milk 
      allergy are wide-ranging and depend on the mechanism involved. There are 
      immunoglobulin E (IgE)-mediated, non-IgE-mediated, and mixed mechanisms of food 
      allergy. Symptoms of IgE-mediated cow's milk allergy may be mild or may progress 
      to anaphylaxis, which can be life-threatening. Non-IgE-mediated allergy includes 
      food protein-induced allergic proctocolitis (FPIAP), food protein-induced 
      enterocolitis syndrome, food protein-induced enteropathy, and Heiner syndrome 
      (pulmonary hemosiderosis). These diagnoses comprise about half of all cow's milk 
      allergies. The most common manifestation of cow's milk allergy in infants is 
      FPIAP. FPIAP is commonly seen in healthy, full-term infants who present with 
      rectal bleeding and are otherwise well-appearing. This can occur in both 
      formula-fed and exclusively breastfed infants. Food proteins secreted in maternal 
      breast milk can contribute to the development of these symptoms. Maternal cow's 
      milk elimination diet is often successful in helping resolve symptoms. A period 
      of reintroduction of cow's milk resulting in re-emergence of symptoms in stable 
      asymptomatic infants is an excellent diagnostic tool to confirm a cow's milk 
      allergy. Preterm infants are susceptible to food allergy, as demonstrated from 
      several case reports of necrotizing enterocolitis-like illnesses that responded 
      clinically to cow's milk elimination. Further study is needed about food allergy 
      in the preterm infant population.
CI  - Copyright (c) 2020 by the American Academy of Pediatrics.
FAU - Burris, Amy D
AU  - Burris AD
AD  - Division of Allergy and Immunology and Center for Food Allergy, and.
FAU - Burris, Jonathan
AU  - Burris J
AD  - Division of Neonatology, Department of Pediatrics, University of Rochester School 
      of Medicine and Dentistry and Golisano Children's Hospital, Rochester, NY.
FAU - Jarvinen, Kirsi M
AU  - Jarvinen KM
AD  - Division of Allergy and Immunology and Center for Food Allergy, and.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Neoreviews
JT  - NeoReviews
JID - 101085360
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Female
MH  - Humans
MH  - Immunoglobulin E
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - *Milk Hypersensitivity/diagnosis/therapy
MH  - Milk, Human
EDAT- 2020/12/03 06:00
MHDA- 2021/11/03 06:00
CRDT- 2020/12/02 05:25
PHST- 2020/12/02 05:25 [entrez]
PHST- 2020/12/03 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
AID - 21/12/e795 [pii]
AID - 10.1542/neo.21-12-e795 [doi]
PST - ppublish
SO  - Neoreviews. 2020 Dec;21(12):e795-e808. doi: 10.1542/neo.21-12-e795.