PMID- 33264107
OWN - NLM
STAT- MEDLINE
DCOM- 20220106
LR  - 20220106
IS  - 1533-4058 (Electronic)
IS  - 1533-4058 (Linking)
VI  - 29
IP  - 6
DP  - 2021 Jul 1
TI  - Coexpress of GATA-3 and ER in Anorectal and Head and Neck Squamous Cell Carcinoma 
      Mimicking Metastatic Breast Cancer.
PG  - 409-413
LID - 10.1097/PAI.0000000000000887 [doi]
AB  - GATA binding protein 3 (GATA-3) is a sensitive marker for breast and urothelial 
      carcinomas. In combination with the estrogen receptor (ER), it is often used for 
      differential diagnosis of metastatic carcinomas of breast origin. In this study, 
      we sought to characterize GATA-3 and ER expression in squamous cell carcinoma 
      (SqCC) of various origins to compare with breast carcinoma. Sixty-four SqCC of 
      anorectum (35), head and neck (15), lung (11), and breast (3) as well as 
      urothelial carcinoma (31) were included. In anorectal and head and neck SqCC, 
      GATA-3, and ER was observed in 23/50 (46.0%) and 18/50 (36.0%) of the cases, 
      respectively. The expression of GATA-3 and ER were present in both male and 
      female patients without significant sex predominance. In 2 metastatic SqCC, the 
      GATA-3 and ER expressed similar immunoreactivity compatible with their anorectal 
      primary. Progesterone receptor was only expressed in 2 anorectal SqCC and none of 
      head and neck SqCC or urothelial carcinomas. None of the lung SqCC expressed 
      GATA-3 or ER (0/11). p16 was expressed in the majority of head and neck (6/12) 
      and anorectal SqCC (26/27). Our study demonstrated that the combination of GATA-3 
      and ER positivity is not entirely specific for breast carcinomas, since both 
      stains are expressed in SqCC from anorectal and head and neck origins. Clinical 
      workup for metastatic carcinoma of suspicious breast origin should be cognizant 
      of other tumors with a similar immunohistochemical profile (ie, SqCC).
CI  - Copyright (c) 2020 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Wang, Yihong
AU  - Wang Y
AD  - Department of Pathology and Lab Medicine, Alpert Medical School of Brown 
      University, Providence, RI.
FAU - Lu, Shaolei
AU  - Lu S
FAU - Amin, Ali
AU  - Amin A
FAU - Wang, Lijuan
AU  - Wang L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Appl Immunohistochem Mol Morphol
JT  - Applied immunohistochemistry & molecular morphology : AIMM
JID - 100888796
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (GATA3 protein, human)
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - Biomarkers, Tumor/*metabolism
MH  - Breast Neoplasms/*diagnosis
MH  - Carcinoma, Squamous Cell/*diagnosis
MH  - Diagnosis, Differential
MH  - Female
MH  - GATA3 Transcription Factor/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Neoplasm Metastasis
MH  - Neoplasm Staging
MH  - Receptors, Estrogen/*metabolism
MH  - Rectal Neoplasms/*diagnosis
MH  - Squamous Cell Carcinoma of Head and Neck/*diagnosis
MH  - Urothelium/*metabolism/pathology
COIS- The authors declare no conflict of interest.
EDAT- 2020/12/03 06:00
MHDA- 2022/01/07 06:00
CRDT- 2020/12/02 17:10
PHST- 2020/06/25 00:00 [received]
PHST- 2020/10/19 00:00 [accepted]
PHST- 2020/12/03 06:00 [pubmed]
PHST- 2022/01/07 06:00 [medline]
PHST- 2020/12/02 17:10 [entrez]
AID - 00129039-202107000-00002 [pii]
AID - 10.1097/PAI.0000000000000887 [doi]
PST - ppublish
SO  - Appl Immunohistochem Mol Morphol. 2021 Jul 1;29(6):409-413. doi: 
      10.1097/PAI.0000000000000887.