PMID- 33264213
OWN - NLM
STAT- MEDLINE
DCOM- 20211126
LR  - 20230912
IS  - 1532-0987 (Electronic)
IS  - 0891-3668 (Linking)
VI  - 40
IP  - 4
DP  - 2021 Apr 1
TI  - Kawasaki Disease and Kawasaki Disease Shock Syndrome Hospitalization Rates in the 
      United States, 2006-2018.
PG  - 284-288
LID - 10.1097/INF.0000000000002982 [doi]
AB  - BACKGROUND: Kawasaki disease (KD) is a febrile illness of unknown etiology. 
      Patients with Kawasaki disease shock syndrome (KDSS) may present with clinical 
      signs of poor perfusion and systolic hypotension in addition to typical KD 
      features. The United States Centers for Disease Control and Prevention analyzes 
      and interprets large hospitalization databases as a mechanism for conducting 
      national KD surveillance. METHODS: The Kids' Inpatient Database (KID), the 
      National (Nationwide) Inpatient Sample (NIS), and the IBM MarketScan Commercial 
      (MSC) and MarketScan Medicaid (MSM) databases were analyzed to determine 
      KD-associated hospitalization rates and trends from 2006 to the most recent year 
      of available data. KD and potential KDSS hospitalizations were defined using 
      International Classification of Disease-Clinical Modification codes. RESULTS: For 
      the most recent year, the KD-associated hospitalization rates for children <5 
      years of age were 19.8 (95% CI: 17.2-22.3, KID: 2016), 19.6 (95% CI: 16.8-22.4, 
      NIS: 2017), 19.3 (MSC: 2018), and 18.4 (MSM: 2018) per 100,000. There was no 
      indication of an increase in KD rates over the time period. Rates of potential 
      KDSS among children <18 years of age, ranging from 0.0 to 0.7 per 100,000, 
      increased; coding indicated potential KDSS for approximately 2.8%-5.3% of KD 
      hospitalizations. CONCLUSIONS: Analyses of these large, national databases 
      produced consistent KD-associated hospitalization rates, with no increase over 
      time detected; however, the percentage of KD hospitalizations with potential KDSS 
      increased. Given reports of increasing incidence elsewhere and the recent 
      identification of a novel virus-associated syndrome with possible Kawasaki-like 
      features, continued national surveillance is important to detect changes in 
      disease epidemiology.
CI  - Copyright (c) 2021 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Maddox, Ryan A
AU  - Maddox RA
AD  - From the Division of High-Consequence Pathogens and Pathology, National Center 
      for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and 
      Prevention, US Department of Health and Human Services, Atlanta, Georgia.
FAU - Person, Marissa K
AU  - Person MK
AD  - From the Division of High-Consequence Pathogens and Pathology, National Center 
      for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and 
      Prevention, US Department of Health and Human Services, Atlanta, Georgia.
FAU - Kennedy, Jordan L
AU  - Kennedy JL
AD  - From the Division of High-Consequence Pathogens and Pathology, National Center 
      for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and 
      Prevention, US Department of Health and Human Services, Atlanta, Georgia.
FAU - Leung, Jessica
AU  - Leung J
AD  - Division of Viral Diseases, National Center for Immunization and Respiratory 
      Diseases, Centers for Disease Control and Prevention, US Department of Health and 
      Human Services, Atlanta, Georgia.
FAU - Abrams, Joseph Y
AU  - Abrams JY
AD  - From the Division of High-Consequence Pathogens and Pathology, National Center 
      for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and 
      Prevention, US Department of Health and Human Services, Atlanta, Georgia.
FAU - Haberling, Dana L
AU  - Haberling DL
AD  - From the Division of High-Consequence Pathogens and Pathology, National Center 
      for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and 
      Prevention, US Department of Health and Human Services, Atlanta, Georgia.
FAU - Schonberger, Lawrence B
AU  - Schonberger LB
AD  - From the Division of High-Consequence Pathogens and Pathology, National Center 
      for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and 
      Prevention, US Department of Health and Human Services, Atlanta, Georgia.
FAU - Belay, Ermias D
AU  - Belay ED
AD  - From the Division of High-Consequence Pathogens and Pathology, National Center 
      for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and 
      Prevention, US Department of Health and Human Services, Atlanta, Georgia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Infect Dis J
JT  - The Pediatric infectious disease journal
JID - 8701858
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Databases, Factual/*statistics & numerical data
MH  - Epidemiological Monitoring
MH  - Female
MH  - Hospitalization/*statistics & numerical data/*trends
MH  - Humans
MH  - Infant
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/classification/complications/*epidemiology
MH  - Shock/classification/*epidemiology
MH  - United States/epidemiology
COIS- The authors have no funding or conflicts of interest to disclose.
EDAT- 2020/12/03 06:00
MHDA- 2021/11/27 06:00
CRDT- 2020/12/02 17:10
PHST- 2020/12/03 06:00 [pubmed]
PHST- 2021/11/27 06:00 [medline]
PHST- 2020/12/02 17:10 [entrez]
AID - 00006454-202104000-00004 [pii]
AID - 10.1097/INF.0000000000002982 [doi]
PST - ppublish
SO  - Pediatr Infect Dis J. 2021 Apr 1;40(4):284-288. doi: 
      10.1097/INF.0000000000002982.