PMID- 33264709
OWN - NLM
STAT- MEDLINE
DCOM- 20210920
LR  - 20210920
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Print)
IS  - 0197-4580 (Linking)
VI  - 98
DP  - 2021 Feb
TI  - Cerebrospinal fluid Abeta42 moderates the relationship between brain functional 
      network dynamics and cognitive intraindividual variability.
PG  - 116-123
LID - S0197-4580(20)30339-0 [pii]
LID - 10.1016/j.neurobiolaging.2020.10.027 [doi]
AB  - As Alzheimer's disease (AD) pathology accumulates, resting-state functional 
      connectivity (rs-fc) within and between brain networks decreases, and 
      fluctuations in cognitive performance known as intraindividual variability (IIV) 
      increase. Here, we assessed the relationship between IIV and anticorrelations in 
      rs-fc between the default mode network (DMN)-dorsal attention network (DAN) in 
      cognitively normal older adults and symptomatic AD participants. We also 
      evaluated the relationship between cerebrospinal fluid (CSF) biomarkers of AD 
      (amyloid-beta [Abeta(42)] and tau) and IIV-anticorrelation in rs-fc. We observed 
      that cognitive IIV and anticorrelations between DMN x DAN were higher in 
      individuals with AD compared with cognitively normal participants. As DMN x DAN 
      relationship became more positive, cognitive IIV increased, indicating that 
      stronger anticorrelations between networks support more consistent cognitive 
      performance. Moderation analyses indicated that continuous CSF Abeta(42), but not 
      CSF total tau, moderated the relationship between cognitive IIV and DMN x DAN, 
      collectively demonstrating that greater amyloid burden and alterations in 
      functional network dynamics are associated with cognitive changes seen in AD. 
      These findings are valuable, as they suggest that amyloid affects cognitive 
      functioning during the early stages of AD.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Meeker, Karin L
AU  - Meeker KL
AD  - Department of Psychology, Saint Louis University, St. Louis, MO, USA; Department 
      of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, 
      MO, USA. Electronic address: kmeeker@wustl.edu.
FAU - Ances, Beau M
AU  - Ances BM
AD  - Department of Neurology, School of Medicine, Washington University in St. Louis, 
      St. Louis, MO, USA.
FAU - Gordon, Brian A
AU  - Gordon BA
AD  - Department of Radiology, School of Medicine, Washington University in St. Louis, 
      St. Louis, MO, USA.
FAU - Rudolph, Cort W
AU  - Rudolph CW
AD  - Department of Psychology, Saint Louis University, St. Louis, MO, USA.
FAU - Luckett, Patrick
AU  - Luckett P
AD  - Department of Neurology, School of Medicine, Washington University in St. Louis, 
      St. Louis, MO, USA.
FAU - Balota, David A
AU  - Balota DA
AD  - Department of Psychology, School of Medicine, Washington University in St. Louis, 
      St. Louis, MO, USA.
FAU - Morris, John C
AU  - Morris JC
AD  - Department of Neurology, School of Medicine, Washington University in St. Louis, 
      St. Louis, MO, USA.
FAU - Fagan, Anne M
AU  - Fagan AM
AD  - Department of Neurology, School of Medicine, Washington University in St. Louis, 
      St. Louis, MO, USA.
FAU - Benzinger, Tammie L
AU  - Benzinger TL
AD  - Department of Radiology, School of Medicine, Washington University in St. Louis, 
      St. Louis, MO, USA.
FAU - Waring, Jill D
AU  - Waring JD
AD  - Department of Psychology, Saint Louis University, St. Louis, MO, USA.
LA  - eng
GR  - P30 AG066444/AG/NIA NIH HHS/United States
GR  - K01 AG053474/AG/NIA NIH HHS/United States
GR  - P01 AG026276/AG/NIA NIH HHS/United States
GR  - R01 NR012907/NR/NINR NIH HHS/United States
GR  - R01 EB009352/EB/NIBIB NIH HHS/United States
GR  - R01 AG057680/AG/NIA NIH HHS/United States
GR  - R01 NR012657/NR/NINR NIH HHS/United States
GR  - UL1 TR000448/TR/NCATS NIH HHS/United States
GR  - R01 AG052550/AG/NIA NIH HHS/United States
GR  - Z01 AG000391/ImNIH/Intramural NIH HHS/United States
GR  - UL1 TR002345/TR/NCATS NIH HHS/United States
GR  - U19 AG032438/AG/NIA NIH HHS/United States
GR  - P01 AG003991/AG/NIA NIH HHS/United States
GR  - P50 AG005681/AG/NIA NIH HHS/United States
GR  - R01 NR014449/NR/NINR NIH HHS/United States
GR  - R01 AG054567/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20201102
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (amyloid beta-protein (1-42))
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/diagnosis/physiopathology/*psychology
MH  - Amyloid beta-Peptides/*cerebrospinal fluid
MH  - Biomarkers/cerebrospinal fluid
MH  - Brain/*physiology
MH  - *Cognition
MH  - Female
MH  - Humans
MH  - Male
MH  - Nerve Net/*physiology
MH  - Peptide Fragments/*cerebrospinal fluid
PMC - PMC7903895
MID - NIHMS1668377
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Anticorrelation
OT  - Abeta42
OT  - Cognitive intraindividual variability
OT  - Functional networks
COIS- Potential Conflicts of Interest: Karin L. Meeker reports no disclosures Beau M. 
      Ances reports no disclosures Brian A. Gordon reports no disclosures Cort W. 
      Rudolph reports no disclosures Patrick Luckett reports no disclosures John C. 
      Morris reports no disclosures Anne M. Fagan reports no disclosures Tammie L. 
      Benzinger reports no disclosures David A. Balota reports no disclosures Jill D. 
      Waring reports no disclosures
EDAT- 2020/12/03 06:00
MHDA- 2021/09/21 06:00
PMCR- 2021/02/24
CRDT- 2020/12/02 20:06
PHST- 2020/05/21 00:00 [received]
PHST- 2020/10/26 00:00 [revised]
PHST- 2020/10/28 00:00 [accepted]
PHST- 2020/12/03 06:00 [pubmed]
PHST- 2021/09/21 06:00 [medline]
PHST- 2020/12/02 20:06 [entrez]
PHST- 2021/02/24 00:00 [pmc-release]
AID - S0197-4580(20)30339-0 [pii]
AID - 10.1016/j.neurobiolaging.2020.10.027 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2021 Feb;98:116-123. doi: 10.1016/j.neurobiolaging.2020.10.027. 
      Epub 2020 Nov 2.