PMID- 33266382
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201207
IS  - 2075-1729 (Print)
IS  - 2075-1729 (Electronic)
IS  - 2075-1729 (Linking)
VI  - 10
IP  - 11
DP  - 2020 Nov 22
TI  - Red Blood Cell Distribution Width Is Associated with Deterioration of Renal 
      Function and Cardiovascular Morbidity and Mortality in Patients with Diabetic 
      Kidney Disease.
LID - 10.3390/life10110301 [doi]
LID - 301
AB  - We sought to investigate the possible association between Red Blood Cell 
      Distribution Width (RDW), vascular calcification, oxidative stress and renal 
      function and all-cause/cardiovascular (CV) mortality, CV events and progression 
      of kidney disease in a cohort of patients with Diabetic Kidney Disease (DKD). 
      Carotid intima media thickness (cIMT) and oxidized low-density cholesterol were 
      measured in 104 Type 2 Diabetes Mellitus (T2DM) patients with established DKD, 
      distributed in all five stages of kidney disease and 38 diabetics with normal 
      renal function. All patients were followed for 7 years with end-points all-cause 
      and CV mortality, CV events and progression to End-Stage Renal Disease (ESRD). 
      RDW was positively correlated with diabetes duration (r = 0.19, p = 0.023) and 
      albuminuria (r = 0.29, p = 0.002). Multivariate regression analysis revealed that 
      RDW was a strong, independent predictor of cIMT value (beta = 0.031, p = 0.012). 
      Kaplan-Meier curves and Cox proportional hazard models revealed that after 
      adjustment for several cofounders, RDW was a significant and independent 
      predictor for all-cause mortality, CV mortality, CV event and progression to ESRD 
      (HR 1.75, p = 0.001, HR 2.03, p = 0.001, HR = 1.66, p < 0.0001 and HR 2.14, p = 
      0.001 respectively). RDW predicts mortality, CV events and deterioration of renal 
      function in DKD, probably reflecting atherosclerosis.
FAU - Roumeliotis, Stefanos
AU  - Roumeliotis S
AD  - Division of Nephrology and Hypertension, 1st Department of Internal Medicine, 
      AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 
      Thessaloniki, Greece.
FAU - Stamou, Aikaterini
AU  - Stamou A
AD  - Department of Microbiology, AHEPA Hospital, School of Medicine, Aristotle 
      University of Thessaloniki, 54636 Thessaloniki, Greece.
FAU - Roumeliotis, Athanasios
AU  - Roumeliotis A
AD  - Division of Nephrology and Hypertension, 1st Department of Internal Medicine, 
      AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 
      Thessaloniki, Greece.
FAU - Theodoridis, Marios
AU  - Theodoridis M
AUID- ORCID: 0000-0002-4993-7668
AD  - Department of Nephrology, School of Medicine, Democritus University of Thrace, 
      68100 Alexandroupolis, Greece.
FAU - Leivaditis, Konstantinos
AU  - Leivaditis K
AD  - Division of Nephrology and Hypertension, 1st Department of Internal Medicine, 
      AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 
      Thessaloniki, Greece.
FAU - Panagoutsos, Stylianos
AU  - Panagoutsos S
AD  - Department of Nephrology, School of Medicine, Democritus University of Thrace, 
      68100 Alexandroupolis, Greece.
FAU - Liakopoulos, Vassilios
AU  - Liakopoulos V
AUID- ORCID: 0000-0002-7564-2724
AD  - Division of Nephrology and Hypertension, 1st Department of Internal Medicine, 
      AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 
      Thessaloniki, Greece.
LA  - eng
PT  - Journal Article
DEP - 20201122
PL  - Switzerland
TA  - Life (Basel)
JT  - Life (Basel, Switzerland)
JID - 101580444
PMC - PMC7700598
OTO - NOTNLM
OT  - cardiovascular events
OT  - diabetic kidney disease
OT  - mortality
OT  - red blood distribution width
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2020/12/04 06:00
MHDA- 2020/12/04 06:01
PMCR- 2020/11/01
CRDT- 2020/12/03 01:06
PHST- 2020/10/22 00:00 [received]
PHST- 2020/11/11 00:00 [revised]
PHST- 2020/11/20 00:00 [accepted]
PHST- 2020/12/03 01:06 [entrez]
PHST- 2020/12/04 06:00 [pubmed]
PHST- 2020/12/04 06:01 [medline]
PHST- 2020/11/01 00:00 [pmc-release]
AID - life10110301 [pii]
AID - life-10-00301 [pii]
AID - 10.3390/life10110301 [doi]
PST - epublish
SO  - Life (Basel). 2020 Nov 22;10(11):301. doi: 10.3390/life10110301.