PMID- 33271244
OWN - NLM
STAT- MEDLINE
DCOM- 20210305
LR  - 20210305
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 268
DP  - 2021 Mar 25
TI  - Assessing the safety of using the dry extract of Justicia pectoralis Jacq. 
      (Acanthaceae) during pregnancy of Wistar rats.
PG  - 113618
LID - S0378-8741(20)33506-6 [pii]
LID - 10.1016/j.jep.2020.113618 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Justicia pectoralis Jacq. (Acanthaceae), 
      popularly known as tilo, chamba and anador, is widely used in folk medicine in 
      Latin American countries as a sedative, anti-anxiety, reducing menopause symptoms 
      and in the treatment of pathologies of the respiratory tract. Although J. 
      pectoralis is widely used by the female population, there are no studies on the 
      safety of using this species during pregnancy. AIM OF THIS STUDY: To evaluate the 
      effects of prenatal treatment with dry extract from the aerial parts of J. 
      pectoralis on maternal and developmental toxicity in Wistar rats. MATERIAL AND 
      METHODS: Pregnant Wistar rats (n = 10/group) were treated from gestational day 
      (GD) 0-20 with the vehicle (control group) or with the dry extract of J. 
      pectoralis at doses of 300, 600 or 1200 mg/kg. During pregnancy, clinical signs 
      of toxicity, maternal weight, feed and water intake were evaluated. On GD 21, 
      rats were anesthetized and intracardiac blood was collected to evaluate 
      biochemical parameters. During cesarean section, reproductive performance 
      parameters were recorded. The liver, kidneys, uterus and ovaries were removed for 
      histopathological analysis. Fetuses were examined for possible malformations 
      and/or skeletal and visceral variations. RESULTS: Treatment with dry extract of 
      J. pectoralis did not alter weight gain, feed intake or biochemical and maternal 
      reproductive performance parameters There were also no significant 
      histopathological changes in the maternal organs, as well as external, skeletal 
      and visceral malformations in the fetuses. CONCLUSION: Oral administration of J. 
      pectoralis dry extract during pregnancy did not induce maternal toxicity or 
      embryotoxic and teratogenic effects.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Carvalho, Marielly
AU  - Carvalho M
AD  - Programa de Pos-Graduacao em Ciencias Aplicadas a Produtos para Saude (CAPS), 
      Universidade Estadual de Goias, Campus Anapolis de Ciencias Exatas e 
      Tecnologicas, Br 153, 3105, Anapolis, GO, 75132-400, Brazil; Laboratorio de 
      Farmacologia e Toxicologia de Produtos Naturais e Sinteticos, Universidade 
      Estadual de Goias, Campus Anapolis de Ciencias Exatas e Tecnologicas, Br 153, 
      3105, Anapolis, GO, 75132-903, Brazil.
FAU - Caixeta, Graziele Alicia Batista
AU  - Caixeta GAB
AD  - Laboratorio de Farmacologia e Toxicologia de Produtos Naturais e Sinteticos, 
      Universidade Estadual de Goias, Campus Anapolis de Ciencias Exatas e 
      Tecnologicas, Br 153, 3105, Anapolis, GO, 75132-903, Brazil.
FAU - Lima, Alessandra Ribeiro Sartor
AU  - Lima ARS
AD  - Programa de Pos-Graduacao em Ciencias Aplicadas a Produtos para Saude (CAPS), 
      Universidade Estadual de Goias, Campus Anapolis de Ciencias Exatas e 
      Tecnologicas, Br 153, 3105, Anapolis, GO, 75132-400, Brazil; Laboratorio de 
      Pesquisa, Desenvolvimento & Inovacao de Produtos da Biodiversidade, Universidade 
      Estadual de Goias, Campus Anapolis de Ciencias Exatas e Tecnologicas, Br 153, 
      3105, Anapolis, GO, 75132-903, Brazil.
FAU - Teofilo, Monatha Nayara Guimaraes
AU  - Teofilo MNG
AD  - Universidade Federal de Goias, Instituto de Ciencias Biologicas (ICB-2), Avenida 
      Esperanca, S/n, Campus Samambaia (Campus II), Goiania, GO, 74690-900, Brazil.
FAU - Cruvinel, Wilson de Melo
AU  - Cruvinel WM
AD  - Pontificia Universidade Catolica de Goias, Escola de Ciencias Medicas, 
      Farmaceuticas e Biomedicas, EFMB, Avenida Universitaria, 1069- Area 4, Bloco K, 
      Setor Leste Universitario, Goiania, GO, 74605-010, Brazil.
FAU - Gomes, Clayson Moura
AU  - Gomes CM
AD  - Pontificia Universidade Catolica de Goias, Escola de Ciencias Medicas, 
      Farmaceuticas e Biomedicas, EFMB, Avenida Universitaria, 1069- Area 4, Bloco K, 
      Setor Leste Universitario, Goiania, GO, 74605-010, Brazil.
FAU - Fleury, Luiz Fernando Froes
AU  - Fleury LFF
AD  - Pontificia Universidade Catolica de Goias, Escola de Ciencias Medicas, 
      Farmaceuticas e Biomedicas, EFMB, Avenida Universitaria, 1069- Area 4, Bloco K, 
      Setor Leste Universitario, Goiania, GO, 74605-010, Brazil.
FAU - Paula, Joelma Abadia Marciano de
AU  - Paula JAM
AD  - Programa de Pos-Graduacao em Ciencias Aplicadas a Produtos para Saude (CAPS), 
      Universidade Estadual de Goias, Campus Anapolis de Ciencias Exatas e 
      Tecnologicas, Br 153, 3105, Anapolis, GO, 75132-400, Brazil; Laboratorio de 
      Pesquisa, Desenvolvimento & Inovacao de Produtos da Biodiversidade, Universidade 
      Estadual de Goias, Campus Anapolis de Ciencias Exatas e Tecnologicas, Br 153, 
      3105, Anapolis, GO, 75132-903, Brazil.
FAU - Amaral, Vanessa Cristiane Santana
AU  - Amaral VCS
AD  - Programa de Pos-Graduacao em Ciencias Aplicadas a Produtos para Saude (CAPS), 
      Universidade Estadual de Goias, Campus Anapolis de Ciencias Exatas e 
      Tecnologicas, Br 153, 3105, Anapolis, GO, 75132-400, Brazil; Laboratorio de 
      Farmacologia e Toxicologia de Produtos Naturais e Sinteticos, Universidade 
      Estadual de Goias, Campus Anapolis de Ciencias Exatas e Tecnologicas, Br 153, 
      3105, Anapolis, GO, 75132-903, Brazil. Electronic address: 
      vanessa.cristiane@ueg.br.
LA  - eng
PT  - Journal Article
DEP - 20201130
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Biomarkers, Pharmacological)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Acanthaceae
MH  - Animals
MH  - Biomarkers, Pharmacological/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - *Justicia
MH  - *Maternal Exposure/adverse effects
MH  - Plant Extracts/isolation & purification/*pharmacology/toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/chemically induced/metabolism
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Embryotoxicity
OT  - Maternal toxicity
OT  - Reproductive performance
OT  - Teratogenicity
OT  - Tilo
EDAT- 2020/12/04 06:00
MHDA- 2021/03/06 06:00
CRDT- 2020/12/03 20:10
PHST- 2020/02/04 00:00 [received]
PHST- 2020/10/14 00:00 [revised]
PHST- 2020/11/23 00:00 [accepted]
PHST- 2020/12/04 06:00 [pubmed]
PHST- 2021/03/06 06:00 [medline]
PHST- 2020/12/03 20:10 [entrez]
AID - S0378-8741(20)33506-6 [pii]
AID - 10.1016/j.jep.2020.113618 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2021 Mar 25;268:113618. doi: 10.1016/j.jep.2020.113618. Epub 
      2020 Nov 30.