PMID- 33271594
OWN - NLM
STAT- MEDLINE
DCOM- 20210622
LR  - 20230216
IS  - 2156-5376 (Electronic)
IS  - 2161-8313 (Print)
IS  - 2161-8313 (Linking)
VI  - 12
IP  - 3
DP  - 2021 Jun 1
TI  - The Potential of Resveratrol to Act as a Caloric Restriction Mimetic Appears to 
      Be Limited: Insights from Studies in Mice.
PG  - 995-1005
LID - 10.1093/advances/nmaa148 [doi]
AB  - Caloric restriction (CR) has been shown repeatedly to prolong the lifespan in 
      laboratory animals, with its benefits dependent on molecular targets forming part 
      of the nutrient signaling network, including the NAD-dependent deacetylase silent 
      mating type information regulation 2 homologue 1 (SIRT1). It has been 
      hypothesized that the stilbene resveratrol (RSV) may counteract age- and 
      obesity-related diseases similarly to CR. In yeast and worms, RSV-promoted 
      longevity also depended on SIRT1. While it remains unclear whether RSV can 
      prolong lifespans in mammals, some studies in rodents supplemented with RSV have 
      reported lowered body weight (BW) and fat mass, improved insulin sensitivity, 
      lowered cholesterol levels, increased fitness, and mitochondrial biogenesis. 
      Molecular mechanisms possibly leading to such changes include altered gene 
      transcription and activation of SIRT1, AMP-activated kinase (AMPK), and 
      peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A). 
      However, some mouse models did not benefit from RSV treatment to the same extent 
      as others. We conducted a literature search on PubMed (15 April, 2020) for trials 
      directly comparing RSV application to CR feeding in mice. In most studies 
      retrieved by this systematic PubMed search, mice supplemented with RSV did not 
      show significant reductions of BW, glucose, or insulin. Moreover, in some of 
      these studies, RSV and CR treatments affected molecular targets differently 
      and/or findings on RSV and CR impacts varied between trials. We discuss those 
      RSV-induced changes in gene transcription hypothesized to partly counteract 
      age-related alterations. Although there may be a moderate effect of RSV 
      supplementation on parameters such as insulin sensitivity toward a more CR-like 
      profile in mice, data are inconsistent. Likewise, RSV supplementation trials in 
      humans report controversial findings. While we consider that RSV may, under 
      certain circumstances, moderately mimic some aspects of CR, current evidence does 
      not fully support its use to prevent or treat age- or obesity-related diseases.
CI  - (c) The Author(s) 2020. Published by Oxford University Press on behalf of the 
      American Society for Nutrition.
FAU - Pallauf, Kathrin
AU  - Pallauf K
AUID- ORCID: 0000-0002-7223-2738
AD  - Institute of Human Nutrition and Food Science, University of Kiel, Kiel, Germany.
FAU - Gunther, Ilka
AU  - Gunther I
AD  - Institute of Human Nutrition and Food Science, University of Kiel, Kiel, Germany.
FAU - Kuhn, Gianna
AU  - Kuhn G
AD  - Institute of Human Nutrition and Food Science, University of Kiel, Kiel, Germany.
FAU - Chin, Dawn
AU  - Chin D
AD  - Institute of Human Nutrition and Food Science, University of Kiel, Kiel, Germany.
FAU - de Pascual-Teresa, Sonia
AU  - de Pascual-Teresa S
AD  - Department of Metabolism and Nutrition, Institute of Food Science, Technology and 
      Nutrition (ICTAN-CSIC), Madrid, Spain.
FAU - Rimbach, Gerald
AU  - Rimbach G
AD  - Institute of Human Nutrition and Food Science, University of Kiel, Kiel, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Adv Nutr
JT  - Advances in nutrition (Bethesda, Md.)
JID - 101540874
RN  - 0 (Insulin)
RN  - 0 (Stilbenes)
RN  - EC 3.5.1.- (Sirtuin 1)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - *Caloric Restriction
MH  - Humans
MH  - Insulin
MH  - Mice
MH  - Resveratrol/pharmacology
MH  - Sirtuin 1
MH  - *Stilbenes/pharmacology
PMC - PMC8166566
OTO - NOTNLM
OT  - diabetes mellitus type II
OT  - dihydroresveratrol
OT  - healthspan
OT  - lunularin
OT  - polyphenol
OT  - sirtuin
EDAT- 2020/12/04 06:00
MHDA- 2021/06/23 06:00
PMCR- 2021/12/03
CRDT- 2020/12/03 20:15
PHST- 2020/05/31 00:00 [received]
PHST- 2020/07/13 00:00 [revised]
PHST- 2020/10/21 00:00 [accepted]
PHST- 2020/12/04 06:00 [pubmed]
PHST- 2021/06/23 06:00 [medline]
PHST- 2020/12/03 20:15 [entrez]
PHST- 2021/12/03 00:00 [pmc-release]
AID - S2161-8313(22)00113-2 [pii]
AID - nmaa148 [pii]
AID - 10.1093/advances/nmaa148 [doi]
PST - ppublish
SO  - Adv Nutr. 2021 Jun 1;12(3):995-1005. doi: 10.1093/advances/nmaa148.