PMID- 33271967
OWN - NLM
STAT- MEDLINE
DCOM- 20210309
LR  - 20210309
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 23
DP  - 2020 Dec 1
TI  - Versatile Types of Polysaccharide-Based Drug Delivery Systems: From Strategic 
      Design to Cancer Therapy.
LID - 10.3390/ijms21239159 [doi]
LID - 9159
AB  - Chemotherapy is still the most direct and effective means of cancer therapy 
      nowadays. The proposal of drug delivery systems (DDSs) has effectively improved 
      many shortcomings of traditional chemotherapy drugs. The technical support of 
      DDSs lies in their excellent material properties. Polysaccharides include a 
      series of natural polymers, such as chitosan, hyaluronic acid, and alginic acid. 
      These polysaccharides have good biocompatibility and degradability, and they are 
      easily chemical modified. Therefore, polysaccharides are ideal candidate 
      materials to construct DDSs, and their clinical application prospects have been 
      favored by researchers. On the basis of versatile types of polysaccharides, this 
      review elaborates their applications from strategic design to cancer therapy. The 
      construction and modification methods of polysaccharide-based DDSs are 
      specifically explained, and the latest research progress of polysaccharide-based 
      DDSs in cancer therapy are also summarized. The purpose of this review is to 
      provide a reference for the design and preparation of polysaccharide-based DDSs 
      with excellent performance.
FAU - Sun, Yanzhen
AU  - Sun Y
AD  - Institute of Biomedical Materials and Engineering, College of Materials Science 
      and Engineering, Qingdao University, Qingdao 266071, China.
FAU - Jing, Xiaodong
AU  - Jing X
AD  - Institute of Biomedical Materials and Engineering, College of Materials Science 
      and Engineering, Qingdao University, Qingdao 266071, China.
FAU - Ma, Xiaoli
AU  - Ma X
AD  - Qingdao Institute of Measurement Technology, Qingdao 266000, China.
FAU - Feng, Yinglong
AU  - Feng Y
AD  - Institute of Biomedical Materials and Engineering, College of Materials Science 
      and Engineering, Qingdao University, Qingdao 266071, China.
FAU - Hu, Hao
AU  - Hu H
AUID- ORCID: 0000-0003-4796-9882
AD  - Institute of Biomedical Materials and Engineering, College of Materials Science 
      and Engineering, Qingdao University, Qingdao 266071, China.
LA  - eng
GR  - 51703105/National Natural Science Foundation of China/
GR  - ZR2017BEM012/Natural Science Foundation of Shandong Province/
GR  - 2018M630752/China Postdoctoral Science Foundation/
PT  - Journal Article
PT  - Review
DEP - 20201201
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Hydrogels)
RN  - 0 (Polymers)
RN  - 0 (Polysaccharides)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/administration & dosage
MH  - Chitosan/chemistry
MH  - Drug Carriers/*chemistry
MH  - *Drug Delivery Systems
MH  - Drug Design
MH  - Humans
MH  - Hyaluronic Acid/administration & dosage
MH  - Hydrogels/chemistry
MH  - Polymers/chemistry
MH  - Polysaccharides/*chemistry
MH  - Structure-Activity Relationship
PMC - PMC7729619
OTO - NOTNLM
OT  - cancer therapy
OT  - chemotherapy
OT  - drug delivery system (DDS)
OT  - polysaccharide
COIS- There are no conflicts of interest to declare.
EDAT- 2020/12/05 06:00
MHDA- 2021/03/10 06:00
PMCR- 2020/12/01
CRDT- 2020/12/04 01:01
PHST- 2020/11/19 00:00 [received]
PHST- 2020/11/29 00:00 [revised]
PHST- 2020/11/30 00:00 [accepted]
PHST- 2020/12/04 01:01 [entrez]
PHST- 2020/12/05 06:00 [pubmed]
PHST- 2021/03/10 06:00 [medline]
PHST- 2020/12/01 00:00 [pmc-release]
AID - ijms21239159 [pii]
AID - ijms-21-09159 [pii]
AID - 10.3390/ijms21239159 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Dec 1;21(23):9159. doi: 10.3390/ijms21239159.