PMID- 33273500 OWN - NLM STAT- MEDLINE DCOM- 20210317 LR - 20240330 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 10 IP - 1 DP - 2020 Dec 3 TI - Characterizing the type 2 diabetes mellitus epidemic in Jordan up to 2050. PG - 21001 LID - 10.1038/s41598-020-77970-7 [doi] LID - 21001 AB - We aimed to characterize the type 2 diabetes mellitus (T2DM) epidemic and the role of key risk factors in Jordan between 1990-2050, and to forecast the T2DM-related costs. A recently-developed population-level T2DM mathematical model was adapted and applied to Jordan. The model was fitted to six population-based survey data collected between 1990 and 2017. T2DM prevalence was 14.0% in 1990, and projected to be 16.0% in 2020, and 20.6% in 2050. The total predicted number of T2DM cases were 218,326 (12,313 were new cases) in 1990, 702,326 (36,941 were new cases) in 2020, and 1.9 million (79,419 were new cases) in 2050. Out of Jordan's total health expenditure, 19.0% in 1990, 21.1% in 2020, and 25.2% in 2050 was forecasted to be spent on T2DM. The proportion of T2DM incident cases attributed to obesity was 55.6% in 1990, 59.5% in 2020, and 62.6% in 2050. Meanwhile, the combined contribution of smoking and physical inactivity hovered around 5% between 1990 and 2050. Jordan's T2DM epidemic is predicted to grow sizably in the next three decades, driven by population ageing and high and increasing obesity levels. The national strategy to prevent T2DM needs to be strengthened by focusing it on preventive interventions targeting T2DM and key risk factors. FAU - Awad, Susanne F AU - Awad SF AD - Infectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation - Education City, P.O. Box 24144, Doha, Qatar. sua2006@qatar-med.cornell.edu. AD - World Health Organization Collaborating Centre for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis, Weill Cornell Medicine -Qatar, Doha, Qatar. sua2006@qatar-med.cornell.edu. AD - Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, USA. sua2006@qatar-med.cornell.edu. FAU - Huangfu, Peijue AU - Huangfu P AD - Population Health Research Institute, St George's, University of London, London, UK. FAU - Dargham, Soha R AU - Dargham SR AD - Infectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation - Education City, P.O. Box 24144, Doha, Qatar. AD - World Health Organization Collaborating Centre for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis, Weill Cornell Medicine -Qatar, Doha, Qatar. FAU - Ajlouni, Kamel AU - Ajlouni K AD - The National Centre for Diabetes, Endocrine and Genetics, The University of Jordan, Amman, Jordan. FAU - Batieha, Anwar AU - Batieha A AD - Department of Public Health and Community Medicine, Jordan University of Science and Technology, Irbid, Jordan. FAU - Khader, Yousef S AU - Khader YS AD - Department of Public Health and Community Medicine, Jordan University of Science and Technology, Irbid, Jordan. FAU - Critchley, Julia A AU - Critchley JA AD - Population Health Research Institute, St George's, University of London, London, UK. FAU - Abu-Raddad, Laith J AU - Abu-Raddad LJ AD - Infectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation - Education City, P.O. Box 24144, Doha, Qatar. lja2002@qatar-med.cornell.edu. AD - World Health Organization Collaborating Centre for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis, Weill Cornell Medicine -Qatar, Doha, Qatar. lja2002@qatar-med.cornell.edu. AD - Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, USA. lja2002@qatar-med.cornell.edu. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20201203 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Adolescent MH - Adult MH - Child MH - Diabetes Mellitus, Type 2/economics/*epidemiology MH - Epidemics/*statistics & numerical data MH - Female MH - Health Expenditures MH - Humans MH - Jordan MH - Male MH - Obesity/epidemiology MH - Sedentary Behavior MH - Smoking/epidemiology PMC - PMC7713435 COIS- The authors declare no competing interests. EDAT- 2020/12/05 06:00 MHDA- 2021/03/18 06:00 PMCR- 2020/12/03 CRDT- 2020/12/04 05:41 PHST- 2020/05/21 00:00 [received] PHST- 2020/11/18 00:00 [accepted] PHST- 2020/12/04 05:41 [entrez] PHST- 2020/12/05 06:00 [pubmed] PHST- 2021/03/18 06:00 [medline] PHST- 2020/12/03 00:00 [pmc-release] AID - 10.1038/s41598-020-77970-7 [pii] AID - 77970 [pii] AID - 10.1038/s41598-020-77970-7 [doi] PST - epublish SO - Sci Rep. 2020 Dec 3;10(1):21001. doi: 10.1038/s41598-020-77970-7.