PMID- 33276116
OWN - NLM
STAT- MEDLINE
DCOM- 20210316
LR  - 20210316
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Linking)
VI  - 126
IP  - 3
DP  - 2021 Mar
TI  - The spectrum of allergic ocular diseases.
PG  - 240-254
LID - S1081-1206(20)31220-5 [pii]
LID - 10.1016/j.anai.2020.11.016 [doi]
AB  - OBJECTIVE: The purpose of this article is to review the pathophysiologic 
      mechanisms, differential diagnosis, evaluation, and treatment of the various 
      manifestations of ocular allergy, with an especial focus on immunoglobulin E 
      (IgE)-mediated disease. DATA SOURCES: A PubMed search was performed to include 
      articles, using the search terms ocular allergy and allergic conjunctivitis. 
      STUDY SELECTIONS: Recent and relevant human studies in the English language 
      pertaining to our topic of study were selected. Animal studies pertaining to 
      pathophysiology of ocular allergy were also reviewed. We focused on clinical 
      trials, practice guidelines, reviews, and systematic reviews. In addition, case 
      reports were reviewed if they described rare clinical presentations, disease 
      mechanisms, or novel therapies. RESULTS: Ocular allergy encompasses both IgE- and 
      non-IgE-mediated disease, and the clinical severity may range from mild to 
      sight-threatening inflammation. A comprehensive treatment regimen including 
      education, lifestyle measures, topical therapies, and even systemic interventions 
      may be necessary for the effective management of ocular allergies, tailored 
      according to symptom severity. CONCLUSION: Ocular allergy is frequently 
      encountered by allergists and eye-care specialists, and despite progressively 
      increasing incidence, it often remains underdiagnosed and, hence, untreated.
CI  - Copyright (c) 2021 American College of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Rodrigues, Jonathan
AU  - Rodrigues J
AD  - Allergy & Immunology, Sanford Health, Bismarck, North Dakota; Department of 
      Internal Medicine and Department of Pediatrics, University of North Dakota School 
      of Medicine and Health Sciences, Grand Forks, North Dakota. Electronic address: 
      jonathan.rodrigues@sanfordhealth.org.
FAU - Kuruvilla, Merin E
AU  - Kuruvilla ME
AD  - Division of Pulmonary, Allergy, Critical Care, and Sleep, Department of Medicine, 
      Emory University School of Medicine, Atlanta, Georgia.
FAU - Vanijcharoenkarn, Kristine
AU  - Vanijcharoenkarn K
AD  - Division of Pulmonary, Allergy, Critical Care, and Sleep, Department of Medicine, 
      Emory University School of Medicine, Atlanta, Georgia.
FAU - Patel, Nikki
AU  - Patel N
AD  - Allergy & Immunology, Sanford Health, Sioux Falls, South Dakota.
FAU - Hom, Milton M
AU  - Hom MM
AD  - Canyon City Eyecare, Azusa, California.
FAU - Wallace, Dana V
AU  - Wallace DV
AD  - Allergy and Immunology, Nova Southeastern University, Davie, Florida.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201201
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Conjunctivitis, Allergic/diagnosis/*immunology/*physiopathology/therapy
MH  - Diagnosis, Differential
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Keratoconjunctivitis/diagnosis/*immunology/*physiopathology/therapy
EDAT- 2020/12/05 06:00
MHDA- 2021/03/17 06:00
CRDT- 2020/12/04 20:09
PHST- 2020/07/13 00:00 [received]
PHST- 2020/11/23 00:00 [revised]
PHST- 2020/11/24 00:00 [accepted]
PHST- 2020/12/05 06:00 [pubmed]
PHST- 2021/03/17 06:00 [medline]
PHST- 2020/12/04 20:09 [entrez]
AID - S1081-1206(20)31220-5 [pii]
AID - 10.1016/j.anai.2020.11.016 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2021 Mar;126(3):240-254. doi: 
      10.1016/j.anai.2020.11.016. Epub 2020 Dec 1.