PMID- 33276239
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 2211-0356 (Electronic)
IS  - 2211-0348 (Linking)
VI  - 47
DP  - 2021 Jan
TI  - Variability of cerebrospinal fluid findings by attack phenotype in myelin 
      oligodendrocyte glycoprotein-IgG-associated disorder.
PG  - 102638
LID - S2211-0348(20)30712-4 [pii]
LID - 10.1016/j.msard.2020.102638 [doi]
AB  - BACKGROUND: The variability in cerebrospinal fluid (CSF) findings of myelin 
      oligodendrocyte glycoprotein-IgG-associated disorder (MOGAD) is not fully 
      elucidated. OBJECTIVE AND METHODS: We retrospectively analyzed 203 
      attack-associated CSFs from Mayo Clinic patients (2000-2019) with MOGAD. RESULTS: 
      White-blood-cell (>5/mm(3)) elevation was less with clinically isolated optic 
      neuritis (23%), compared to myelitis, brain/brainstem attacks, or combinations 
      thereof (>70%), p<0.0001. CSF pleocytosis in optic neuritis was more common in 
      patients with coexisting asymptomatic brain and/or spine MRI T2-lesions (53%) 
      than in those without (16%), p=0.005. Abnormal CSF oligoclonal bands ranged from 
      1% (optic neuritis) to 18% (brain/brainstem attacks). CSF pleocytosis was less 
      common after immunotherapy. CONCLUSIONS: CSF findings in MOGAD vary by attack 
      phenotype and preceding treatment.
CI  - Copyright (c) 2020. Published by Elsevier B.V.
FAU - Sechi, Elia
AU  - Sechi E
AD  - Department of Neurology, Mayo Clinic, Rochester, MN, USA; Department of 
      Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Verona, 
      Italy.
FAU - Buciuc, Marina
AU  - Buciuc M
AD  - Department of Neurology, Mayo Clinic, Rochester, MN, USA.
FAU - Flanagan, Eoin P
AU  - Flanagan EP
AD  - Department of Neurology, Laboratory Medicine and Pathology, Mayo Clinic, 
      Rochester, MN, USA.
FAU - Pittock, Sean J
AU  - Pittock SJ
AD  - Department of Neurology, Laboratory Medicine and Pathology, Mayo Clinic, 
      Rochester, MN, USA.
FAU - Banks, Samantha A
AU  - Banks SA
AD  - Department of Neurology, Mayo Clinic, Rochester, MN, USA.
FAU - Lopez-Chiriboga, A Sebastian
AU  - Lopez-Chiriboga AS
AD  - Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
FAU - Bhatti, M Tariq
AU  - Bhatti MT
AD  - Department of Neurology and Ophthalmology, Mayo Clinic, Rochester, MN, USA.
FAU - Chen, John J
AU  - Chen JJ
AD  - Department of Neurology and Ophthalmology, Mayo Clinic, Rochester, MN, USA. 
      Electronic address: chen.john@mayo.edu.
LA  - eng
PT  - Letter
DEP - 20201123
PL  - Netherlands
TA  - Mult Scler Relat Disord
JT  - Multiple sclerosis and related disorders
JID - 101580247
RN  - 0 (Aquaporin 4)
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
SB  - IM
MH  - *Aquaporin 4
MH  - Autoantibodies
MH  - Humans
MH  - Immunoglobulin G
MH  - Myelin-Oligodendrocyte Glycoprotein
MH  - *Neuromyelitis Optica
MH  - Phenotype
MH  - Retrospective Studies
OTO - NOTNLM
OT  - (1) MOG
OT  - (2) CSF (3) neuromyelitis optica spectrum disorder
OT  - (4) NMOSD
OT  - (5) oligoclonal bands
OT  - (6) optic neuritis
EDAT- 2020/12/05 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/12/04 20:10
PHST- 2020/10/11 00:00 [received]
PHST- 2020/11/13 00:00 [revised]
PHST- 2020/11/18 00:00 [accepted]
PHST- 2020/12/05 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/12/04 20:10 [entrez]
AID - S2211-0348(20)30712-4 [pii]
AID - 10.1016/j.msard.2020.102638 [doi]
PST - ppublish
SO  - Mult Scler Relat Disord. 2021 Jan;47:102638. doi: 10.1016/j.msard.2020.102638. 
      Epub 2020 Nov 23.