PMID- 33276518
OWN - NLM
STAT- MEDLINE
DCOM- 20210429
LR  - 20210429
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 12
IP  - 12
DP  - 2020 Dec 2
TI  - Effects of Oral Resveratrol Supplementation on Glycogen Replenishment and 
      Mitochondria Biogenesis in Exercised Human Skeletal Muscle.
LID - 10.3390/nu12123721 [doi]
LID - 3721
AB  - The present study aimed to investigate the effect of oral resveratrol 
      supplementation on the key molecular gene expressions involved in mitochondria 
      biogenesis and glycogen resynthesis in human skeletal muscle. Nine young male 
      athletes participated in the single-blind and crossover designed study. All 
      subjects completed a 4-day resveratrol and placebo supplement in a randomized 
      order while performing a single bout of cycling exercise. Immediately after the 
      exercise challenge, the subjects consumed a carbohydrate (CHO) meal (2 g CHO/Kg 
      body mass) with either resveratrol or placebo capsules. Biopsied muscle samples, 
      blood samples and expired gas samples were obtained at 0 h and 3 h after 
      exercise. The muscle samples were measured for gene transcription factor 
      expression by real-time PCR for glucose uptake and mitochondria biogenesis. 
      Plasma glucose, insulin, glycerol, non-esterified fatty acid concentrations and 
      respiratory exchange ratio were analyzed during post-exercise recovery periods. 
      The results showed that the muscle glycogen concentrations were higher at 3 h 
      than at 0 h; however, there were no difference between resveratrol trial and 
      placebo trial. There were no significantly different concentrations in plasma 
      parameters between the two trials. Similarly, no measured gene expressions were 
      significant between the two trials. The evidence concluded that the 4-day oral 
      resveratrol supplementation did not improve post-exercise muscle glycogen 
      resynthesis and related glucose uptake and mitochondrial biosynthesis gene 
      expression in men.
FAU - Huang, Chun-Ching
AU  - Huang CC
AD  - Department of Exercise and Health Sciences, National Taipei University of Nursing 
      and Health Science, Taipei City 112, Taiwan.
FAU - Liu, Chia-Chen
AU  - Liu CC
AD  - Department of Physical Education, National Taichung University of Education, 
      Taichung City 403, Taiwan.
FAU - Tsao, Jung-Piao
AU  - Tsao JP
AD  - Department of Physical Education, National Taichung University of Education, 
      Taichung City 403, Taiwan.
FAU - Hsu, Chin-Lin
AU  - Hsu CL
AUID- ORCID: 0000-0002-0315-625X
AD  - Department of Nutrition, Chung Shan Medical University Hospital, Taichung 404, 
      Taiwan.
AD  - School of Nutrition, Chung Shan Medical University, Taichung 404, Taiwan.
FAU - Cheng, I-Shiung
AU  - Cheng IS
AD  - Department of Physical Education, National Taichung University of Education, 
      Taichung City 403, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20201202
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (RNA, Messenger)
RN  - 9005-79-2 (Glycogen)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Blood Glucose/metabolism
MH  - *Dietary Supplements
MH  - Energy Metabolism
MH  - Exercise/*physiology
MH  - Glycogen/*metabolism
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Mitochondria/*metabolism
MH  - Muscle, Skeletal/*metabolism
MH  - RNA, Messenger
MH  - Resveratrol/*pharmacology
MH  - Single-Blind Method
MH  - Young Adult
PMC - PMC7760965
OTO - NOTNLM
OT  - cycling exercise
OT  - energy metabolism
OT  - ergogenic aids
OT  - muscle physiology
COIS- The authors declare no conflict of interest.
EDAT- 2020/12/06 06:00
MHDA- 2021/04/30 06:00
PMCR- 2020/12/02
CRDT- 2020/12/05 01:01
PHST- 2020/10/31 00:00 [received]
PHST- 2020/11/28 00:00 [revised]
PHST- 2020/11/29 00:00 [accepted]
PHST- 2020/12/05 01:01 [entrez]
PHST- 2020/12/06 06:00 [pubmed]
PHST- 2021/04/30 06:00 [medline]
PHST- 2020/12/02 00:00 [pmc-release]
AID - nu12123721 [pii]
AID - nutrients-12-03721 [pii]
AID - 10.3390/nu12123721 [doi]
PST - epublish
SO  - Nutrients. 2020 Dec 2;12(12):3721. doi: 10.3390/nu12123721.