PMID- 33276661
OWN - NLM
STAT- MEDLINE
DCOM- 20210429
LR  - 20210429
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 12
IP  - 12
DP  - 2020 Dec 2
TI  - Interdisciplinary Significance of Food-Related Adverse Reactions in Adulthood.
LID - 10.3390/nu12123725 [doi]
LID - 3725
AB  - Background: Adults frequently interpret food-associated adverse reactions as 
      indicators of a food allergy. However, the public perception of food allergy may 
      differ from a clinician's point of view. The prevalence of patient-reported food 
      allergy tends to be higher than physician-confirmed cases. Dermatological 
      manifestations (urticaria, pruritus, dermatitis, and edema) are frequently 
      reported by patients. Objective: The aim of this study was to describe 
      patient-reported symptoms related to suspected food allergies and particularly to 
      characterize and highlight the volume of patients who visit Budapest allergy 
      clinics with suspected food allergies. Methods: In this prospective study, adult 
      (>/=18 years) patients were examined at the Allergology Outpatient Unit of the 
      Dept. of Dermatology, Venereology, and Dermatooncology, Semmelweis University, 
      Budapest. The examination included a detailed medical history; physical 
      examination; and when necessary the measurement of allergen-specific serum 
      immunoglobulin E (IgE) levels. Results: Data from 501 patients (393 women, 108 
      men) were analyzed. Intolerance to dietary biogenic amines occurred in 250 cases 
      (250/501, 50%). Oral allergy syndrome was confirmed in 71 patients (71/501, 14%). 
      Allergy to food preservatives was diagnosed in 14 (14/501, 3%) cases by a 
      dermatologist-allergist specialist. Five individuals (5/501, 1%) were diagnosed 
      with IgE-mediated food allergy. In some cases (28/501, 6%), 
      edema-inducing/enhancing side effects of drugs were observed which patients had 
      misattributed to various foods. Among the food groups considered to be provoking 
      factors, the most frequently mentioned were fruits (198/501, 40%), milk/dairy 
      products (174/501, 35%), and nuts/oilseeds (144/501, 29%). Overwhelmingly, 
      urticaria (47%) was the most common dermatological diagnosis, followed by 
      dermatitis (20%) and allergic contact dermatitis (8%). Conclusion: Improvement is 
      needed in food allergy, food intolerance, and general nutritional knowledge among 
      the general public. According to our data, perceived/self-reported food allergies 
      were overestimated by adults when compared against physician-confirmed food 
      allergies; however, other diseases potentially responsible for food-related 
      problems were underestimated. The prevalence of oral allergy syndrome was high in 
      the cohort. Intolerance to dietary biogenic amines was common, and although the 
      role of dietary histamine and biogenic amine is not entirely understood in 
      eliciting patients' symptoms, improvements in complaints were reported during the 
      control visits.
FAU - Solymosi, Dora
AU  - Solymosi D
AUID- ORCID: 0000-0002-8095-6365
AD  - Department of Dermatology, Venereology and Dermatooncology, Semmelweis 
      University, 1085 Budapest, Hungary.
AD  - Doctoral School of Clinical Medicine, Semmelweis University, 1085 Budapest, 
      Hungary.
FAU - Sardy, Miklos
AU  - Sardy M
AD  - Department of Dermatology, Venereology and Dermatooncology, Semmelweis 
      University, 1085 Budapest, Hungary.
FAU - Ponyai, Gyorgyi
AU  - Ponyai G
AD  - Department of Dermatology, Venereology and Dermatooncology, Semmelweis 
      University, 1085 Budapest, Hungary.
LA  - eng
PT  - Journal Article
DEP - 20201202
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Allergens)
RN  - 0 (Biogenic Amines)
RN  - 0 (Food Preservatives)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Allergens/adverse effects
MH  - Biogenic Amines/administration & dosage
MH  - Dermatitis/epidemiology
MH  - Edema/epidemiology
MH  - Female
MH  - Food Hypersensitivity/*diagnosis/*epidemiology/*physiopathology
MH  - Food Intolerance
MH  - Food Preservatives/adverse effects
MH  - Histamine
MH  - Humans
MH  - Hungary/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Nuts
MH  - Prevalence
MH  - Pruritus/epidemiology
MH  - Respiratory Hypersensitivity
MH  - Self Report
MH  - Urticaria/epidemiology
MH  - Young Adult
PMC - PMC7761565
OTO - NOTNLM
OT  - allergy to preservatives
OT  - dietary biogenic amines
OT  - food adverse reaction
OT  - food allergy
OT  - food intolerance
OT  - histamine intolerance
OT  - oral allergy syndrome
OT  - physician-diagnosed
OT  - self-reported
OT  - urticaria
COIS- The authors declare no conflict of interest relevant to this manuscript.
EDAT- 2020/12/06 06:00
MHDA- 2021/04/30 06:00
PMCR- 2020/12/02
CRDT- 2020/12/05 01:01
PHST- 2020/10/20 00:00 [received]
PHST- 2020/11/21 00:00 [revised]
PHST- 2020/12/01 00:00 [accepted]
PHST- 2020/12/05 01:01 [entrez]
PHST- 2020/12/06 06:00 [pubmed]
PHST- 2021/04/30 06:00 [medline]
PHST- 2020/12/02 00:00 [pmc-release]
AID - nu12123725 [pii]
AID - nutrients-12-03725 [pii]
AID - 10.3390/nu12123725 [doi]
PST - epublish
SO  - Nutrients. 2020 Dec 2;12(12):3725. doi: 10.3390/nu12123725.