PMID- 33277510
OWN - NLM
STAT- MEDLINE
DCOM- 20210525
LR  - 20210525
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Dec 4
TI  - Altered regional homogeneity and functional brain networks in Type 2 diabetes 
      with and without mild cognitive impairment.
PG  - 21254
LID - 10.1038/s41598-020-76495-3 [doi]
LID - 21254
AB  - Patients with Type-2 Diabetes Mellitus (T2DM) have a considerably higher risk of 
      developing mild cognitive impairment (MCI) and dementia. The initial symptoms are 
      very insidious at onset. We investigated the alterations in spontaneous brain 
      activity and network connectivity through regional homogeneity (ReHo) and graph 
      theoretical network analyses, respectively, of resting-state functional Magnetic 
      Resonance Imaging (rs-fMRI) in T2DM patients with and without MCI, so as to 
      facilitate early diagnose. Twenty-five T2DM patients with MCI (DM-MCI), 25 T2DM 
      patients with normal cognition (DM-NC), 27 healthy controls were enrolled. 
      Whole-brain ReHo values were calculated and topological properties of functional 
      networks were analyzed. The DM-MCI group exhibited decreased ReHo in the left 
      inferior/middle occipital gyrus and right inferior temporal gyrus, and increased 
      ReHo in frontal gyrus compared to the DM-NCs. Significant correlations were found 
      between ReHo values and clinical measurements. The DM-MCI group illustrated 
      greater clustering coefficient/local efficiency and altered nodal characteristics 
      (efficiency, degree and betweenness), which increased in certain occipital, 
      temporal and parietal regions but decreased in the right inferior temporal gyrus, 
      compared to the DM-NCs. The altered ReHo and impaired network organization may 
      underlie the impaired cognitive functions in T2DM and suggesting a compensation 
      mechanism. These rs-fMRI measures have the potential as biomarkers of disease 
      progression in diabetic encephalopathy.
FAU - Xiong, Ying
AU  - Xiong Y
AUID- ORCID: 0000-0002-6270-5220
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China.
FAU - Chen, Xiaodan
AU  - Chen X
AD  - State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern 
      Institute for Brain Research, Beijing Normal University, Beijing, China.
FAU - Zhao, Xu
AU  - Zhao X
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China.
FAU - Fan, Yang
AU  - Fan Y
AD  - GE Healthcare, Beijing, China.
FAU - Zhang, Qiang
AU  - Zhang Q
AD  - Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China. 
      zhangqiang_glia@126.com.
FAU - Zhu, Wenzhen
AU  - Zhu W
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China. 
      zhuwenzhen8612@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201204
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Brain/diagnostic imaging/*physiopathology
MH  - Cognitive Dysfunction/*diagnostic imaging/*physiopathology
MH  - Diabetes Mellitus, Type 2/*diagnostic imaging/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
PMC - PMC7718881
COIS- The authors declare no competing interests.
EDAT- 2020/12/06 06:00
MHDA- 2021/05/26 06:00
PMCR- 2020/12/04
CRDT- 2020/12/05 05:29
PHST- 2020/01/09 00:00 [received]
PHST- 2020/10/26 00:00 [accepted]
PHST- 2020/12/05 05:29 [entrez]
PHST- 2020/12/06 06:00 [pubmed]
PHST- 2021/05/26 06:00 [medline]
PHST- 2020/12/04 00:00 [pmc-release]
AID - 10.1038/s41598-020-76495-3 [pii]
AID - 76495 [pii]
AID - 10.1038/s41598-020-76495-3 [doi]
PST - epublish
SO  - Sci Rep. 2020 Dec 4;10(1):21254. doi: 10.1038/s41598-020-76495-3.