PMID- 33277698
OWN - NLM
STAT- MEDLINE
DCOM- 20210708
LR  - 20210708
IS  - 1745-4514 (Electronic)
IS  - 0145-8884 (Linking)
VI  - 45
IP  - 1
DP  - 2021 Jan
TI  - Mulberry leaf attenuates atherosclerotic lesions in patients with coronary heart 
      disease possibly via 1-Deoxynojirimycin: A placebo-controlled, double-blind 
      clinical trial.
PG  - e13573
LID - 10.1111/jfbc.13573 [doi]
AB  - Mulberry leaf tea reduces atherosclerotic lesions and its main component is 
      Deoxynojirimycin (DNJ). We aimed to explore the effects of Mulberry leaf DNJ 
      (MLD) on atherosclerotic lesions in the patients with coronary heart disease 
      (CHD). MLD and serum DNJ was detected by high-performance liquid chromatography 
      (HPLC). The CHD patients with low-density lipoprotein cholesterol >140 mg/dl were 
      assigned into the EG (MLD treatment) and the CG (placebo treatment) groups. Serum 
      biochemical indices, the cerebrovascular and cardiovascular events and carotid 
      intima-media thickness (IMT) were measured before and after a 1-year 
      intervention. Pearson Correlation Coefficient test was used to explore the 
      relationship between serum levels of DNJ and IMT values. Serum DNJ was 
      70 +/- 50 ng/ml in the EG group but no serum DNJ was detected in the CG group. The 
      incidence of cerebrovascular and cardiovascular events in the EG was lower than 
      that in the CG group (p < .05). MLD therapy improved antioxidant and 
      anti-inflammatory properties and serum lipid profile (p < .05). The IMT values in 
      the EG group were lower than those in the CG group (p < .05). Serum levels of DNJ 
      had a strong negative relationship with IMT values. MLD treatment attenuates 
      atherosclerotic lesions possibly via DNJ. PRACTICAL APPLICATIONS: Mulberry leaves 
      Deoxynojirimycin (MLD) treatment improved antioxidant and anti-inflammatory 
      properties and serum lipid profile in heart disease patients. MLD reduce carotid 
      intima-media thickness (IMT) and serum levels of DNJ (the main ingredient of 
      mulberry leaf) had a strong relationship with IMT values. MLD is an amazing treat 
      used for reducing the incidence of cerebrovascular and cardiovascular events in 
      heart disease patients.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Wang, Yuting
AU  - Wang Y
AD  - Department of Cardiovascular, The First Hospital of Jilin University, Changchun, 
      China.
FAU - Yu, Zhongwei
AU  - Yu Z
AD  - The Third Operating Room, The First Hospital of Jilin University, Changchun, 
      China.
FAU - Jiang, Jun
AU  - Jiang J
AD  - Department of Cardiovascular, The First Hospital of Jilin University, Changchun, 
      China.
FAU - Li, Yaxin
AU  - Li Y
AUID- ORCID: 0000-0003-3205-3740
AD  - Department of Cardiovascular, The First Hospital of Jilin University, Changchun, 
      China.
FAU - Yu, Shui
AU  - Yu S
AD  - Department of Cardiovascular, The First Hospital of Jilin University, Changchun, 
      China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20201205
PL  - United States
TA  - J Food Biochem
JT  - Journal of food biochemistry
JID - 7706045
RN  - 19130-96-2 (1-Deoxynojirimycin)
SB  - IM
MH  - 1-Deoxynojirimycin/therapeutic use
MH  - *Atherosclerosis
MH  - Carotid Intima-Media Thickness
MH  - *Coronary Disease/drug therapy
MH  - Humans
MH  - *Morus
MH  - Plant Leaves
OTO - NOTNLM
OT  - atherosclerotic events
OT  - carotid intima-media thickness
OT  - coronary heart disease
OT  - deoxynojirimycin
OT  - mulberry leaf
EDAT- 2020/12/06 06:00
MHDA- 2021/07/09 06:00
CRDT- 2020/12/05 05:33
PHST- 2020/09/12 00:00 [received]
PHST- 2020/10/28 00:00 [revised]
PHST- 2020/11/09 00:00 [accepted]
PHST- 2020/12/06 06:00 [pubmed]
PHST- 2021/07/09 06:00 [medline]
PHST- 2020/12/05 05:33 [entrez]
AID - 10.1111/jfbc.13573 [doi]
PST - ppublish
SO  - J Food Biochem. 2021 Jan;45(1):e13573. doi: 10.1111/jfbc.13573. Epub 2020 Dec 5.