PMID- 33277851
OWN - NLM
STAT- MEDLINE
DCOM- 20210820
LR  - 20210926
IS  - 2241-6293 (Electronic)
IS  - 1107-0625 (Linking)
VI  - 25
IP  - 5
DP  - 2020 Sep-Oct
TI  - MicroRNA-23 regulates the growth, metastasis and chemosensitivity of human 
      gastric cancer cells by targeting MAP3K9.
PG  - 2315-2321
AB  - PURPOSE: The efficient therapeutic targets which could be utilized for gastric 
      cancer are limited. In this context, this study was undertaken to evaluate 
      possible anticancer activity of miR-23 against gastric cancer. METHODS: The 
      normal GES-1 and human AGS, SNU-1 and SNU-5 gastric cancer cells were used in 
      this study. qRT-PCR was used for the determination of miR-23 expression. MTT 
      assay was used for cell viability and acridine orange (AO)/ethidium bromide (EB) 
      assay was used for detection of apoptosis. The experiments were performed in 
      triplicate. RESULTS: The microRNA (miR)-23 was downregulated in gastric cancer 
      cells and showed inhibitory effect on cell growth which was manifested as decline 
      in cell survival. Additionally, the chemosensitivity of gastric cancer cells to 
      cisplatin was enhanced with miR-23 overexpression. Furthermore, miR-23 also 
      inhibited the migration and invasion of cancer cells. MAP3K9 was shown to be the 
      target gene of miR-23 and silencing of MAP3K9 was seen to mimic the growth 
      inhibitory effect of miR-23. Overexpression of MAP3K9 reversed the growth 
      inhibition in miR-23 mimics transfected gastric cancer cells. CONCLUSION: miR-23 
      exerts growth inhibitory effect against gastric cancer cells and negatively 
      regulates the cell migration and invasion along with enhancement of 
      chemosensitivity of cancer cells.
FAU - Li, Deping
AU  - Li D
AD  - Department of Gastroenterology, Taihe Hospital, Hubei University of Medicine, 
      Shiyan City, Hubei Province, 442000, China.
FAU - Wang, Juan
AU  - Wang J
FAU - Hui, Yuanjian
AU  - Hui Y
FAU - Yang, Yan
AU  - Yang Y
FAU - Peng, Xingchun
AU  - Peng X
FAU - Li, Shengbao
AU  - Li S
FAU - Sun, Chuantao
AU  - Sun C
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
RN  - 0 (MIRN23a microRNA, human)
RN  - 0 (MicroRNAs)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinases)
RN  - EC 2.7.11.25 (MAP3K9 protein, human)
SB  - IM
RIN - J BUON. 2021 Jul-Aug;26(4):1695. PMID: 34565051
MH  - Apoptosis
MH  - Cell Movement
MH  - Cell Proliferation
MH  - Humans
MH  - MAP Kinase Kinase Kinases/*metabolism
MH  - MicroRNAs/*metabolism
MH  - Neoplasm Metastasis
MH  - Stomach Neoplasms/*genetics/pathology
EDAT- 2020/12/06 06:00
MHDA- 2021/08/21 06:00
CRDT- 2020/12/05 05:35
PHST- 2021/08/31 00:00 [retracted]
PHST- 2020/12/05 05:35 [entrez]
PHST- 2020/12/06 06:00 [pubmed]
PHST- 2021/08/21 06:00 [medline]
PST - ppublish
SO  - J BUON. 2020 Sep-Oct;25(5):2315-2321.