PMID- 33277863
OWN - NLM
STAT- MEDLINE
DCOM- 20210820
LR  - 20210926
IS  - 2241-6293 (Electronic)
IS  - 1107-0625 (Linking)
VI  - 25
IP  - 5
DP  - 2020 Sep-Oct
TI  - Anticancer effects of ovatodiolide on human prostate cancer cells involves cell 
      cycle arrest, apoptosis and blocking of Ras/Raf/MEK/ERK signaling pathway.
PG  - 2412-2417
AB  - PURPOSE: The current research was set with a goal to characterize the anticancer 
      role of ovatodiolide against human prostate cancer along with the underlying 
      mechanism of its action. METHODS: The proliferation of prostate cancer cells was 
      assessed by using the CCK8 reagent. DAPI and acridine orange (AO)/ ethidium 
      bromide (EB) staining procedures were employed for the analysis of cell 
      apoptosis. Flow cytometric examination of prostate cancer cells was undertaken 
      for the mitotic cell cycle analysis. The western blotting technique was used for 
      the inference of expression levels of the proteins of interest. RESULTS: In vitro 
      administration of ovatodiolide led to decline of proliferation of prostate cancer 
      cells. The reduction in proliferative rates was attributed to the induction of 
      apoptosis of prostate cancer cells and mitotic cell cycle arrest. Furthermore, 
      the anticancer effects of ovatodiolide on prostate cancer cells were exerted 
      through the inhibition of Ras/Raf/MEK/ERK signaling cascade. CONCLUSION: This 
      study established the anticancer role of diterpenoid ovatodiolide in restricting 
      the growth and proliferation of human prostate cancer cells.
FAU - Jia, Dongsheng
AU  - Jia D
AD  - Department of Urology, Zibo Central Hospital, Zibo, Shandong, 255036 China.
FAU - Zheng, Jianbo
AU  - Zheng J
FAU - Yu, Junli
AU  - Yu J
FAU - Zhao, Ning
AU  - Zhao N
FAU - Lu, Shengxing
AU  - Lu S
FAU - Hao, Dongfang
AU  - Hao D
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
RN  - 0 (Diterpenes)
RN  - 0 (ovatodiolide)
RN  - EC 2.7.11.1 (raf Kinases)
RN  - EC 3.6.5.2 (ras Proteins)
SB  - IM
RIN - J BUON. 2021 Jul-Aug;26(4):1692. PMID: 34565048
MH  - Apoptosis/drug effects
MH  - Cell Cycle Checkpoints/drug effects
MH  - Cell Proliferation/drug effects
MH  - Diterpenes/*pharmacology
MH  - Flow Cytometry
MH  - Humans
MH  - MAP Kinase Signaling System/*drug effects
MH  - Male
MH  - Prostatic Neoplasms/*drug therapy/pathology
MH  - raf Kinases/metabolism
MH  - ras Proteins/metabolism
EDAT- 2020/12/06 06:00
MHDA- 2021/08/21 06:00
CRDT- 2020/12/05 05:35
PHST- 2021/08/31 00:00 [retracted]
PHST- 2020/12/05 05:35 [entrez]
PHST- 2020/12/06 06:00 [pubmed]
PHST- 2021/08/21 06:00 [medline]
PST - ppublish
SO  - J BUON. 2020 Sep-Oct;25(5):2412-2417.