PMID- 33278474 OWN - NLM STAT- MEDLINE DCOM- 20210419 LR - 20220202 IS - 1096-0953 (Electronic) IS - 0013-9351 (Print) IS - 0013-9351 (Linking) VI - 193 DP - 2021 Feb TI - Persistent organic pollutants and maternal glycemic outcomes in a diverse pregnancy cohort of overweight women. PG - 110551 LID - S0013-9351(20)31448-1 [pii] LID - 10.1016/j.envres.2020.110551 [doi] AB - BACKGROUND: Animal and human studies suggest certain persistent organic pollutants (POPs) may impact glucose metabolism; however, few epidemiologic studies have examined environmental determinants of glycemic outcomes during pregnancy. Our objective is to evaluate associations between exposures to individual and mixture of POPs and measures of prenatal fasting glucose, insulin, and insulin resistance during pregnancy in overweight women. METHODS: A cohort of overweight and obese pregnant women (N = 95) was recruited from California. Blood samples were collected during late first or second trimester (median = 16 weeks' gestation; range = 10-24 weeks). Exposures included serum concentrations of polybrominated diphenyl ethers (PBDEs) and hydroxylated metabolites (OH-PBDEs), polychlorinated biphenyls (PCBs), and poly- and perfluoroalkyl substances (PFASs). Outcomes included serum concentrations of fasting plasma glucose, fasting plasma insulin, and calculated homeostatic model assessment of insulin resistance (HOMA-IR). Generalized linear models were used to evaluate cross-sectional associations between individual and aggregate POPs and mean percent difference in fasting glucose, fasting insulin, and HOMA-IR. Bayesian kernel machine regression (BKMR) was used to assess the relative importance of each exposure to the association with our outcomes, using conditional and group posterior inclusion probabilities (PIPs). RESULTS: Study participants were racially/ethnically diverse and nearly half were below the federal poverty level. Across PBDEs and OH-PBDEs, the direction of associations with fasting glucose, fasting insulin and HOMA-IR were varied. A doubling of PCB-138, PCB-153, PCB-180, and summation operatorPCBs concentrations was associated with a 2.10% mmol/L (95%CI: 0.49%, 3.74%), 2.10% mmol/L (95%CI: -0.14%, 4.39%), 2.10% mmol/L (95%CI: 0.12%, 4.12%), and 2.81% mmol/L (95%CI: 0.38%, 5.31%) increase in fasting glucose, respectively. Exposure to individual PCBs was positively associated with both fasting insulin and HOMA-IR. All PFAS were inversely associated with fasting glucose, fasting insulin, and HOMA-IR. In BKMR models of fasting glucose, all four chemical classes were important contributors to the overall mixture, with PFASs identified as the most important contributor. DISCUSSION: Prenatal PCB exposure was positively associated while certain PBDE and PFAS analytes were inversely associated with fasting glucose concentrations in overweight women. Further examination of the relationship between POPs exposure and glycemic functioning in a larger study population of women during pregnancy is warranted. CI - Copyright (c) 2020 Elsevier Inc. All rights reserved. FAU - Mehta, Suril S AU - Mehta SS AD - Department of Environmental and Occupational Health, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA. Electronic address: surilsm@gwu.edu. FAU - James-Todd, Tamarra AU - James-Todd T AD - Department of Environmental Health, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA; Department of Epidemiology, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA. FAU - Applebaum, Katie M AU - Applebaum KM AD - Department of Environmental and Occupational Health, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA. FAU - Bellavia, Andrea AU - Bellavia A AD - Department of Environmental Health, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA. FAU - Coleman-Phox, Kimberly AU - Coleman-Phox K AD - Center for Health and Community, School of Medicine, University of California, San Francisco, San Francisco, CA, USA. FAU - Adler, Nancy AU - Adler N AD - Department of Psychiatry, School of Medicine, University of California, San Francisco, San Francisco, CA, USA. FAU - Laraia, Barbara AU - Laraia B AD - Division of Community Health and Human Development, School of Public Health, University of California, Berkeley, Berkeley, CA, USA. FAU - Epel, Elissa AU - Epel E AD - Department of Psychiatry, School of Medicine, University of California, San Francisco, San Francisco, CA, USA. FAU - Parry, Emily AU - Parry E AD - Environmental Chemistry Laboratory, California Department of Toxic Substances Control, Berkeley, CA, USA. FAU - Wang, Miaomiao AU - Wang M AD - Environmental Chemistry Laboratory, California Department of Toxic Substances Control, Berkeley, CA, USA. FAU - Park, June-Soo AU - Park JS AD - Environmental Chemistry Laboratory, California Department of Toxic Substances Control, Berkeley, CA, USA. FAU - Zota, Ami R AU - Zota AR AD - Department of Environmental and Occupational Health, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA. LA - eng GR - M01 RR001271/RR/NCRR NIH HHS/United States GR - P30 DK098722/DK/NIDDK NIH HHS/United States GR - U01 HL097973/HL/NHLBI NIH HHS/United States GR - R00 ES019881/ES/NIEHS NIH HHS/United States GR - R01 ES026166/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20201202 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (Blood Glucose) RN - 0 (Environmental Pollutants) SB - IM MH - Animals MH - Bayes Theorem MH - Blood Glucose MH - Cross-Sectional Studies MH - *Environmental Pollutants MH - Female MH - Humans MH - Maternal Exposure MH - *Persistent Organic Pollutants MH - Pregnancy PMC - PMC7855882 MID - NIHMS1658047 COIS- Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Conflict of interest statement: The authors declare that they have no conflict of interest. EDAT- 2020/12/06 06:00 MHDA- 2021/04/20 06:00 PMCR- 2022/02/01 CRDT- 2020/12/05 20:09 PHST- 2020/09/14 00:00 [received] PHST- 2020/11/11 00:00 [revised] PHST- 2020/11/24 00:00 [accepted] PHST- 2020/12/06 06:00 [pubmed] PHST- 2021/04/20 06:00 [medline] PHST- 2020/12/05 20:09 [entrez] PHST- 2022/02/01 00:00 [pmc-release] AID - S0013-9351(20)31448-1 [pii] AID - 10.1016/j.envres.2020.110551 [doi] PST - ppublish SO - Environ Res. 2021 Feb;193:110551. doi: 10.1016/j.envres.2020.110551. Epub 2020 Dec 2.