PMID- 33279662
OWN - NLM
STAT- MEDLINE
DCOM- 20210602
LR  - 20210602
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 144
DP  - 2021 Feb
TI  - Effects of branched-chain amino acid supplementation and resistance training in 
      postmenopausal women.
PG  - 111185
LID - S0531-5565(20)30533-7 [pii]
LID - 10.1016/j.exger.2020.111185 [doi]
AB  - BACKGROUND: The age-related loss in muscular function is typically accelerated 
      after menopause. Resistance training (RT) has been shown to increase muscle mass 
      and strength in postmenopausal women. Branched-chain amino acid (BCAA) 
      supplementation acutely increases myofibrillar protein synthesis (MPS) and 
      decreases muscle soreness following RT. However, the combined effects of BCAA 
      supplementation and RT on muscle mass, strength, and regulatory factors on 
      postmenopausal cohorts are currently unknown. The purpose of this study was to 
      explore the combined effects of BCAA supplementation and RT on muscle mass, 
      strength, and regulatory factors in postmenopausal women. METHODS: Thirty 
      postmenopausal women were randomly assigned to one of three conditions: RT and 
      placebo (PLA; n = 10), RT and BCAA (BCAA; 9 g/day; n = 10), or control (CON; 
      n = 10). Muscle mass, strength, and serum concentrations of muscle regulatory 
      factors (myostatin, follistatin, and insulin-like growth factor-1 [IGF-1]) were 
      assessed before and following 8 weeks of whole-body supervised RT (3x/week, 3-4 
      sets using 60-75% 1-repetition maximum [1-RM]). RESULTS: There were significant 
      increases (P < 0.05) in muscle mass and strength in both the PLA and BCAA 
      conditions. Additionally, myostatin significantly (P < 0.05) decreased, while 
      IGF-1 (P < 0.05) increased following PLA and BCAA. However, follistatin 
      significantly increased in the BCAA condition. There were no differences between 
      RT conditions over time. Furthermore, there were no changes in any variable after 
      CON. CONCLUSIONS: Short-term (8 weeks) RT is an effective intervention for 
      improving muscle mass, strength, and muscle regulatory factors in postmenopausal 
      women. The addition of BCAA supplementation to RT failed to augment these 
      physiological changes.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Bagheri, Reza
AU  - Bagheri R
AD  - Department of Exercise Physiology, University of Isfahan, Isfahan, Iran.
FAU - Forbes, Scott C
AU  - Forbes SC
AD  - Department of Physical Education, Brandon University, Brandon, MB, Canada.
FAU - Candow, Darren G
AU  - Candow DG
AD  - Faculty of Kinesiology and Health Studies, University of Regina, Regina, SK, 
      Canada.
FAU - Wong, Alexei
AU  - Wong A
AD  - Department of Health and Human Performance, Marymount University, Arlington, 
      United States. Electronic address: awong@marymount.edu.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20201203
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Amino Acids, Branched-Chain)
SB  - IM
MH  - Amino Acids, Branched-Chain
MH  - Dietary Supplements
MH  - Female
MH  - Humans
MH  - Muscle Strength
MH  - Muscle, Skeletal
MH  - Postmenopause
MH  - *Resistance Training
OTO - NOTNLM
OT  - Body composition
OT  - Branched-chain amino acid
OT  - Myofibrillar protein synthesis
OT  - Postmenopausal women
OT  - Resistance training
EDAT- 2020/12/07 06:00
MHDA- 2021/06/03 06:00
CRDT- 2020/12/06 20:44
PHST- 2020/05/13 00:00 [received]
PHST- 2020/11/25 00:00 [revised]
PHST- 2020/11/30 00:00 [accepted]
PHST- 2020/12/07 06:00 [pubmed]
PHST- 2021/06/03 06:00 [medline]
PHST- 2020/12/06 20:44 [entrez]
AID - S0531-5565(20)30533-7 [pii]
AID - 10.1016/j.exger.2020.111185 [doi]
PST - ppublish
SO  - Exp Gerontol. 2021 Feb;144:111185. doi: 10.1016/j.exger.2020.111185. Epub 2020 
      Dec 3.