PMID- 3328144
OWN - NLM
STAT- MEDLINE
DCOM- 19880428
LR  - 20190903
IS  - 0031-3025 (Print)
IS  - 0031-3025 (Linking)
VI  - 19
IP  - 4
DP  - 1987 Oct
TI  - Detection of alpha-1-antitrypsin in hepatocytes in acute and chronic hepatitis.
PG  - 415-8
AB  - Twelve of sixteen consecutive needle biopsies of liver with either acute or 
      chronic hepatitis showed positive immunohistochemical staining for 
      alpha-1-antitrypsin (AAT). Only two of the positive biopsies contained numerous, 
      large periodic acid-Schiff positive, diastase resistant (PAS-D) globules in 
      periportal hepatocytes; both patients were Pi MZ but only one had a low serum AAT 
      concentration. The other 15 patients had normal or elevated serum AAT. The 
      accumulation of AAT in hepatocytes, demonstrated by sensitive immunohistochemical 
      staining, may indicate increased synthesis and/or impaired secretion of AAT 
      occurring in association with various types of hepatitis.
FAU - Hall, P
AU  - Hall P
AD  - Department of Pathology, Flinders Medical Centre, Adelaide.
FAU - Herrmann, R
AU  - Herrmann R
FAU - Brennan, J
AU  - Brennan J
FAU - Mackinnon, M
AU  - Mackinnon M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pathology
JT  - Pathology
JID - 0175411
RN  - 0 (alpha 1-Antitrypsin)
SB  - IM
MH  - Acute Disease
MH  - Biopsy, Needle
MH  - Chronic Disease
MH  - Hepatitis/*metabolism
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Liver/*analysis
MH  - alpha 1-Antitrypsin/*analysis
EDAT- 1987/10/01 00:00
MHDA- 1987/10/01 00:01
CRDT- 1987/10/01 00:00
PHST- 1987/10/01 00:00 [pubmed]
PHST- 1987/10/01 00:01 [medline]
PHST- 1987/10/01 00:00 [entrez]
AID - 10.3109/00313028709103894 [doi]
PST - ppublish
SO  - Pathology. 1987 Oct;19(4):415-8. doi: 10.3109/00313028709103894.