PMID- 33281540
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201208
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 14
DP  - 2020
TI  - Hyperalgesia and Central Sensitization in Subjects With Chronic Orofacial Pain: 
      Analysis of Pain Thresholds and EEG Biomarkers.
PG  - 552650
LID - 10.3389/fnins.2020.552650 [doi]
LID - 552650
AB  - Introduction: The presence of a temporomandibular disorder is one of the most 
      frequent causes of orofacial pain (OFP). When pain continues beyond tissue 
      healing time, it becomes chronic and may be caused, among other factors, by the 
      sensitization of higher-order neurons. The aim of this study is to describe 
      psychological characteristics of patients with chronic OFP, their peripheral pain 
      threshold, and electroencephalography (EEG) recording, looking for possible signs 
      of central sensitization (CS). Materials and methods: Twenty-four subjects with 
      chronic OFP caused by temporomandibular disorder were evaluated using the 
      Research Diagnostic Criteria for Temporomandibular Disorders Axis I and Axis II. 
      Pain intensity, catastrophizing, and presence of CS were assessed through 
      self-reported questionnaires. Pressure pain threshold (PPT) was recorded in 
      facial and peripheral sites; EEG activity was recorded during open and closed 
      eyes resting state and also during the pain threshold assessment. Pain thresholds 
      and EEG recordings were compared with a cohort of pain-free age- and sex-matched 
      healthy subjects. Results: Patients with chronic OFP showed a significant 
      reduction in their pain threshold compared to healthy subjects in all sites 
      assessed. Greater reduction in pain threshold was recorded in patients with more 
      severe psychological symptoms. Decreased alpha and increased gamma activity was 
      recorded in central and frontal regions of all subjects, although no significant 
      differences were observed between groups. Discussion: A general reduction in PPT 
      was recorded in people who suffer from chronic OFP. This result may be explained 
      by sensitization of the central nervous system due to chronic pain conditions. 
      Abnormal EEG activity was recorded during painful stimulation compared to the 
      relaxed condition in both chronic OFP subjects and healthy controls.
CI  - Copyright (c) 2020 Baroni, Severini, Straudi, Buja, Borsato and Basaglia.
FAU - Baroni, Andrea
AU  - Baroni A
AD  - Translational Neurosciences and Neurotechnologies, Ferrara University, Ferrara, 
      Italy.
AD  - Department of Neuroscience and Rehabilitation, University Hospital of Ferrara, 
      Ferrara, Italy.
FAU - Severini, Giacomo
AU  - Severini G
AD  - School of Electrical and Electronic Engineering, University College Dublin, 
      Dublin, Ireland.
AD  - Centre for Biomedical Engineering, University College Dublin, Dublin, Ireland.
FAU - Straudi, Sofia
AU  - Straudi S
AD  - Department of Neuroscience and Rehabilitation, University Hospital of Ferrara, 
      Ferrara, Italy.
FAU - Buja, Sergio
AU  - Buja S
AD  - Department of Neuroscience and Rehabilitation, University Hospital of Ferrara, 
      Ferrara, Italy.
FAU - Borsato, Silvia
AU  - Borsato S
AD  - Department of Neuroscience and Rehabilitation, University Hospital of Ferrara, 
      Ferrara, Italy.
FAU - Basaglia, Nino
AU  - Basaglia N
AD  - Translational Neurosciences and Neurotechnologies, Ferrara University, Ferrara, 
      Italy.
AD  - Department of Neuroscience and Rehabilitation, University Hospital of Ferrara, 
      Ferrara, Italy.
LA  - eng
PT  - Journal Article
DEP - 20201112
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC7689025
OTO - NOTNLM
OT  - EEG
OT  - central sensitization
OT  - chronic pain
OT  - orofacial pain
OT  - pain threshold
EDAT- 2020/12/08 06:00
MHDA- 2020/12/08 06:01
PMCR- 2020/01/01
CRDT- 2020/12/07 05:30
PHST- 2020/04/16 00:00 [received]
PHST- 2020/10/20 00:00 [accepted]
PHST- 2020/12/07 05:30 [entrez]
PHST- 2020/12/08 06:00 [pubmed]
PHST- 2020/12/08 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2020.552650 [doi]
PST - epublish
SO  - Front Neurosci. 2020 Nov 12;14:552650. doi: 10.3389/fnins.2020.552650. 
      eCollection 2020.