PMID- 33281635
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201208
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 11
DP  - 2020
TI  - SSRI Treatment Response Prediction in Depression Based on Brain Activation by 
      Emotional Stimuli.
PG  - 538393
LID - 10.3389/fpsyt.2020.538393 [doi]
LID - 538393
AB  - Introduction: The prediction of antidepressant treatment response may improve 
      outcome. Functional magnetic resonance imaging (fMRI) of emotion processing in 
      major depressive disorder (MDD) may reveal regional brain function serving as 
      predictors of response to treatment with selective serotonin reuptake inhibitor 
      (SSRI). Methods: We examined the association between pre-treatment neural 
      activity by means of fMRI during the perception of emotional stimuli in 22 
      patients with MDD and the treatment outcome after 6 weeks' medication with an 
      SSRI. A whole brain correlation analysis with Beck Depression Inventory (BDI) 
      change between pre- to post-treatment was conducted to identify neural regions 
      associated with treatment response. Results: During the perception of positive 
      stimuli, responders were characterized by more activation in posterior cingulate 
      cortex (PCC), medial prefrontal cortex, and thalamus as well as middle temporal 
      gyrus. During perception of negative stimuli, PCC, and pregenual anterior 
      cingulate cortex showed the highest correlation with treatment response. 
      Furthermore, responders exhibited higher activation to emotional stimuli than to 
      neutral stimuli in all the above-mentioned regions, while non-responders 
      demonstrated an attenuated neural response to emotional compared to neutral 
      stimuli. Conclusion: Our data suggest that the activity of distinct brain regions 
      is correlated with SSRI treatment outcome and may serve as treatment response 
      predictor. While some regions, in which activity was correlated with treatment 
      response, can be assigned to networks that have been implied in the 
      pathophysiology of depression, most of our regions of interest could also be 
      matched to the default mode network (DMN). Higher DMN activity has been 
      associated with increased rumination as well as negative self-referential 
      processing in previous studies. This may suggest our responders to SSRI to be 
      characterized by such dysregulations and that SSRIs might modify the function 
      associated with this network.
CI  - Copyright (c) 2020 Preuss, Bolliger, Schicho, Hattenschwiler, Seifritz, Bruhl and 
      Herwig.
FAU - Preuss, Antonia
AU  - Preuss A
AD  - Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital 
      for Psychiatry, Zurich, Switzerland.
AD  - Clinic for Psychiatry and Psychotherapy Clienia, Oetwil am See, Switzerland.
FAU - Bolliger, Bianca
AU  - Bolliger B
AD  - Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital 
      for Psychiatry, Zurich, Switzerland.
FAU - Schicho, Wenzel
AU  - Schicho W
AD  - Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital 
      for Psychiatry, Zurich, Switzerland.
FAU - Hattenschwiler, Josef
AU  - Hattenschwiler J
AD  - Center for Treatment of Anxiety and Affection Disorder Zentrum fur Angst- und 
      Depressionsbehandlung Zurich (ZADZ), Zurich, Switzerland.
FAU - Seifritz, Erich
AU  - Seifritz E
AD  - Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital 
      for Psychiatry, Zurich, Switzerland.
FAU - Bruhl, Annette Beatrix
AU  - Bruhl AB
AD  - Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital 
      for Psychiatry, Zurich, Switzerland.
FAU - Herwig, Uwe
AU  - Herwig U
AD  - Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital 
      for Psychiatry, Zurich, Switzerland.
AD  - Center for Psychiatry Reichenau, Academic Hospital University of Konstanz, 
      Konstanz, Germany.
LA  - eng
PT  - Journal Article
DEP - 20201113
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC7691246
OTO - NOTNLM
OT  - SSRI (selective serotonin reuptake inhibitor)
OT  - emotional stimuli
OT  - functional magnet resonance imaging (fMRI)
OT  - major depressive disorder (MDD)
OT  - treatment-outcome
EDAT- 2020/12/08 06:00
MHDA- 2020/12/08 06:01
PMCR- 2020/11/13
CRDT- 2020/12/07 05:30
PHST- 2020/02/27 00:00 [received]
PHST- 2020/09/17 00:00 [accepted]
PHST- 2020/12/07 05:30 [entrez]
PHST- 2020/12/08 06:00 [pubmed]
PHST- 2020/12/08 06:01 [medline]
PHST- 2020/11/13 00:00 [pmc-release]
AID - 10.3389/fpsyt.2020.538393 [doi]
PST - epublish
SO  - Front Psychiatry. 2020 Nov 13;11:538393. doi: 10.3389/fpsyt.2020.538393. 
      eCollection 2020.