PMID- 33282154
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220418
IS  - 1735-3327 (Print)
IS  - 2008-0255 (Electronic)
IS  - 1735-3327 (Linking)
VI  - 17
IP  - 4
DP  - 2020 Jul-Aug
TI  - The comparison of the salivary concentration of interleukin-17 and interleukin-18 
      in patients with chronic periodontitis and healthy individuals.
PG  - 280-286
AB  - BACKGROUND: Regarding the prevalence and importance of periodontal disease and 
      the potential of salivary biomarkers for the early diagnosis of these diseases, 
      this study was conducted to compare salivary concentrations of Interleukin-17 
      (IL-17) and Interleukin-18 (IL-18) in patients with chronic periodontitis and 
      healthy individuals. MATERIALS AND METHODS: The present research was a 
      descriptive-analytical and also a cross-sectional study. Unstimulated saliva with 
      full-mouth clinical periodontal recordings were obtained from 20 healthy 
      individuals and 20 individuals with chronic periodontitis. The concentrations of 
      salivary IL-17 and IL-18 were determined using the enzyme-linked immunosorbent 
      assays. The nonparametric Mann-Whitney U-test was used for statistical analysis 
      of the findings. Alpha level was set at 0.05. RESULTS: The mean salivary 
      concentration of IL-18 in patients with chronic periodontitis was 143.10 pg/mL, 
      which was higher than the same concentration in healthy controls (78.33 pg/mL), 
      (P = 0.035). The mean salivary concentration of IL-17 in patients with chronic 
      periodontitis and healthy controls was 3.51 and 4.57 pg/mL, respectively, and 
      there was no difference between the two groups (P = 0.283). CONCLUSION: Within 
      the limitations of the present study, it may be suggested that an elevated 
      salivary IL-18 level in chronic periodontitis patients has the potential to be a 
      biomarker for periodontal tissue destruction.
CI  - Copyright: (c) 2020 Dental Research Journal.
FAU - Vahabi, Surena
AU  - Vahabi S
AD  - Department of Periodontics, School of Dentistry, Shahid Beheshti University of 
      Medical Sciences, Tehran, Iran.
FAU - Yadegari, Zahra
AU  - Yadegari Z
AD  - Department of Dental Biomaterials, School of Dentistry, Shahid Beheshti 
      University of Medical Sciences, Tehran, Iran.
FAU - Pournaghi, Samaneh
AU  - Pournaghi S
AD  - DDS, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, 
      Iran.
LA  - eng
PT  - Journal Article
DEP - 20200814
PL  - Iran
TA  - Dent Res J (Isfahan)
JT  - Dental research journal
JID - 101471186
PMC - PMC7688042
OTO - NOTNLM
OT  - Interleukin-17
OT  - interleukin-18
OT  - periodontitis
OT  - saliva
COIS- The authors of this manuscript declare that they have no conflicts of interest, 
      real or perceived, financial or non-financial in this article.
EDAT- 2020/12/08 06:00
MHDA- 2020/12/08 06:01
PMCR- 2020/08/14
CRDT- 2020/12/07 05:33
PHST- 2020/12/07 05:33 [entrez]
PHST- 2020/12/08 06:00 [pubmed]
PHST- 2020/12/08 06:01 [medline]
PHST- 2020/08/14 00:00 [pmc-release]
AID - DRJ-17-280 [pii]
PST - epublish
SO  - Dent Res J (Isfahan). 2020 Aug 14;17(4):280-286. eCollection 2020 Jul-Aug.