PMID- 33282373
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220418
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 12
IP  - 11
DP  - 2020 Nov
TI  - Long-term prognosis in patients with end-stage renal disease after coronary 
      artery bypass grafting.
PG  - 6722-6730
LID - 10.21037/jtd-20-2046 [doi]
AB  - BACKGROUND: Cardiovascular disease is a major cause of morbidity and mortality in 
      patients with end-stage renal disease (ESRD). Coronary artery bypass grafting 
      (CABG) is beneficial in selected patients with ESRD. This study investigates the 
      survival outcomes and prognostic factors in ESRD patients who underwent CABG. 
      METHODS: A retrospective analysis was performed for 149 patients with ESRD who 
      underwent isolated CABG between 2006 and 2015. RESULTS: Mean age was 59.4+/-8.7 
      years and 106 patients (71.1%) were male. Operative mortality occurred in 20 
      patients (13.4%). Overall survival was 81.1%+/-3.2% at 1 year, 41.5%+/-4.3% at 5 
      years and 19.2%+/-4.2% at 10 years. Median survival was 4.3 years. Multivariable 
      analysis identified age [P=0.001, odds ratio (OR): 1.15 per 1-year increase, 95% 
      confidence interval (CI): 1.06-1.25], preoperative left ventricular ejection 
      fraction (LVEF) (P=0.020, OR: 0.94, 95% CI: 0.89-0.99) and non-elective status of 
      operation (P=0.049, OR: 3.34, 95% CI: 1.00-11.1) as predictors of operative 
      mortality. Cox regression analysis identified age [P<0.001, hazard ratio (HR): 
      1.05 per 1-year increase, 95% CI: 1.03-1.08], New York Heart Association (NYHA) 
      class III or IV status (P=0.010, HR: 1.75, 95% CI: 1.15-2.67) and the use of a 
      left internal mammary artery (LIMA) to left anterior descending artery (LIMA-LAD) 
      graft (P=0.029, HR: 0.42, 95% CI: 0.19-0.92) as factors influencing long-term 
      survival. CONCLUSIONS: CABG is associated with high operative mortality and poor 
      long-term survival in ESRD patients. Age and NYHA class influenced late survival. 
      LIMA-LAD grafting conferred a long-term survival advantage.
CI  - 2020 Journal of Thoracic Disease. All rights reserved.
FAU - Pang, Philip Y K
AU  - Pang PYK
AD  - Department of Cardiothoracic Surgery, National Heart Centre Singapore, Singapore.
FAU - Teow, Christopher K J
AU  - Teow CKJ
AD  - Ministry of Health Holdings, Singapore.
AD  - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
FAU - Huang, Ming Jie
AU  - Huang MJ
AD  - Department of Cardiothoracic Surgery, National Heart Centre Singapore, Singapore.
FAU - Naik, Madhava J
AU  - Naik MJ
AD  - Department of Cardiothoracic Surgery, National Heart Centre Singapore, Singapore.
FAU - Lim, See Lim
AU  - Lim SL
AD  - Department of Cardiothoracic Surgery, National Heart Centre Singapore, Singapore.
FAU - Chao, Victor T T
AU  - Chao VTT
AD  - Department of Cardiothoracic Surgery, National Heart Centre Singapore, Singapore.
FAU - Tan, Teing Ee
AU  - Tan TE
AD  - Department of Cardiothoracic Surgery, National Heart Centre Singapore, Singapore.
FAU - Chua, Yeow Leng
AU  - Chua YL
AD  - Department of Cardiothoracic Surgery, National Heart Centre Singapore, Singapore.
FAU - Sin, Yoong Kong
AU  - Sin YK
AD  - Department of Cardiothoracic Surgery, National Heart Centre Singapore, Singapore.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC7711392
OTO - NOTNLM
OT  - End-stage renal disease (ESRD)
OT  - coronary artery bypass grafting (CABG)
OT  - coronary artery disease
OT  - dialysis-dependent renal failure
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/jtd-20-2046). The authors have no 
      conflicts of interest to declare.
EDAT- 2020/12/08 06:00
MHDA- 2020/12/08 06:01
PMCR- 2020/11/01
CRDT- 2020/12/07 05:33
PHST- 2020/12/07 05:33 [entrez]
PHST- 2020/12/08 06:00 [pubmed]
PHST- 2020/12/08 06:01 [medline]
PHST- 2020/11/01 00:00 [pmc-release]
AID - jtd-12-11-6722 [pii]
AID - 10.21037/jtd-20-2046 [doi]
PST - ppublish
SO  - J Thorac Dis. 2020 Nov;12(11):6722-6730. doi: 10.21037/jtd-20-2046.