PMID- 33282496
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210103
IS  - 2156-7085 (Print)
IS  - 2156-7085 (Electronic)
IS  - 2156-7085 (Linking)
VI  - 11
IP  - 11
DP  - 2020 Nov 1
TI  - Polarization sensitive optical coherence tomography for imaging microvascular 
      information within living tissue without polarization-induced artifacts.
PG  - 6379-6388
LID - 10.1364/BOE.403933 [doi]
AB  - When imaging birefringent samples using optical coherence tomography angiography 
      (OCTA), the phase retardation may appear opposite to the phase change due to the 
      blood flow in the orthogonal signals, for which a cancellation effect can occur 
      when deriving OCTA signals. This effect can diminish the ability of OCTA to 
      detect vascular information, leading to an erroneous interpretation of the final 
      OCTA images. To mitigate this issue, we demonstrate polarization-sensitive 
      optical coherence tomography (PS-OCT) to image microvascular information within a 
      living sample without polarization induced artifacts. The system is furnished 
      with a swept source OCT (SS-OCT) that incorporates two imaging modes: OCTA 
      imaging and polarization-sensitive imaging. PS-OCT is used to provide 
      birefringent contrast where the color-encoded Stokes parameters are used to 
      obtain high contrast polarization-state images. OCTA is used to acquire 
      high-resolution images of functional microvascular networks permeating the 
      scanned tissue volume. Taking the advantages of the dual-channel PS-OCT 
      configuration, the polarization induced artifacts are eliminated from OCTA 
      vascular imaging. The proposed PS-OCTA system is employed to visualize the 
      birefringent components and the vascular networks of the human skin in vivo. It 
      is expected that the proposed system setup would have useful and practical 
      applications in the investigations of the vasculature in the birefringent tissue 
      samples both pre-clinically and clinically.
CI  - (c) 2020 Optical Society of America under the terms of the OSA Open Access 
      Publishing Agreement.
FAU - Tang, Peijun
AU  - Tang P
AD  - Department of Bioengineering, University of Washington, 3720 15th Avenue NE, 
      Seattle, WA 98195, USA.
FAU - Wang, Ruikang K
AU  - Wang RK
AUID- ORCID: 0000-0001-5169-8822
AD  - Department of Bioengineering, University of Washington, 3720 15th Avenue NE, 
      Seattle, WA 98195, USA.
LA  - eng
GR  - R01 HL141570/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20201015
PL  - United States
TA  - Biomed Opt Express
JT  - Biomedical optics express
JID - 101540630
PMC - PMC7687965
COIS- The authors declare no conflicts of interest.
EDAT- 2020/12/08 06:00
MHDA- 2020/12/08 06:01
PMCR- 2020/11/01
CRDT- 2020/12/07 05:34
PHST- 2020/07/29 00:00 [received]
PHST- 2020/09/20 00:00 [revised]
PHST- 2020/10/09 00:00 [accepted]
PHST- 2020/12/07 05:34 [entrez]
PHST- 2020/12/08 06:00 [pubmed]
PHST- 2020/12/08 06:01 [medline]
PHST- 2020/11/01 00:00 [pmc-release]
AID - 403933 [pii]
AID - 10.1364/BOE.403933 [doi]
PST - epublish
SO  - Biomed Opt Express. 2020 Oct 15;11(11):6379-6388. doi: 10.1364/BOE.403933. 
      eCollection 2020 Nov 1.