PMID- 33283652
OWN - NLM
STAT- MEDLINE
DCOM- 20211125
LR  - 20220427
IS  - 1784-973X (Electronic)
IS  - 0001-5385 (Linking)
VI  - 76
IP  - 7
DP  - 2021 Sep
TI  - Association between serum SCUBE1 levels and thrombus burden in patients with 
      ST-segment elevation myocardial infarction.
PG  - 777-784
LID - 10.1080/00015385.2020.1852753 [doi]
AB  - INTRODUCTION: The signal peptide-CUB-EGF domain-containing protein-1 (SCUBE1) is 
      a recently available biomarker which is expressed by activated and adhered 
      platelets. In present study, we aimed to investigate the association between 
      SCUBE1 levels and thrombus burden in patients with ST elevation myocardial 
      infarction (STEMI) who underwent primary percutaneous coronary intervention 
      (PPCI). METHODS: A total of 88 patients who were diagnosed with STEMI and 
      underwent PPCI were prospectively included between July 2019 and August 2019. 
      Blood samples were collected for routine biochemistry and serum SCUBE1 levels 
      before PPCI and antiplatelet therapy. Angiographic coronary thrombus burden was 
      classified based on thrombolysis in myocardial infarction (TIMI) thrombus grades. 
      We formed two groups based on the thrombus grade: 37 (42%) patients had high 
      thrombus burden whereas 51 (58%) patients had low thrombus burden. RESULTS: The 
      mean age of study population was 58.2 +/- 11.8 years (34% female). The mean peak 
      troponin I level, SCUBE1 level, SYNTAX score, and pain-to-balloon time were 
      significantly higher in the high thrombus burden group compared to the low 
      thrombus burden group (p < .05, for all). In ROC analysis, SCUBE1 level 
      >65.63 ng/dL had a sensitivity of 91.9% and a specificity of 76.6% to predict 
      high thrombus burden (AUC: 0.9256; p < .001). In multivariate analysis, SCUBE1 
      level (HR: 1.133, p = .004) and troponin (HR: 1.002; 95% CI 1.001-1.004, 
      p = .003) were independent predictors of high thrombus burden. CONCLUSION: In the 
      present study, we showed that SCUBE1, a novel platelet-endothelial adhesion 
      molecule and a marker of platelet activation, is an independent predictor of high 
      thrombus burden in patients with STEMI.
FAU - Yildirim, Arafat
AU  - Yildirim A
AUID- ORCID: 0000-0002-2798-7488
AD  - Department of Cardiology, University of Health Sciences - Adana Health Practice 
      and Research Center, Adana, Turkey.
FAU - Kucukosmanoglu, Mehmet
AU  - Kucukosmanoglu M
AUID- ORCID: 0000-0001-9186-3642
AD  - Department of Cardiology, University of Health Sciences - Adana Health Practice 
      and Research Center, Adana, Turkey.
FAU - Koyunsever, Nermin Yildiz
AU  - Koyunsever NY
AUID- ORCID: 0000-0002-0058-1330
AD  - Department of Cardiology, University of Health Sciences - Adana Health Practice 
      and Research Center, Adana, Turkey.
FAU - Cekici, Yusuf
AU  - Cekici Y
AUID- ORCID: 0000-0002-4585-3707
AD  - Department of Cardiology, Usak University Research and Training Hospital, Usak, 
      Turkey.
FAU - Dogdus, Mustafa
AU  - Dogdus M
AUID- ORCID: 0000-0002-3895-1923
AD  - Department of Cardiology, Mehmet Akif Inan Research and Training Hospital, 
      Sanliurfa, Turkey.
FAU - Saracoglu, Erhan
AU  - Saracoglu E
AUID- ORCID: 0000-0003-3797-512X
AD  - Department of Cardiology, University of Health Sciences, Yildirim Beyazit Diskapi 
      Research and Training Hospital, Ankara, Turkey.
FAU - Kilic, Salih
AU  - Kilic S
AUID- ORCID: 0000-0002-3579-3747
AD  - Department of Cardiology, University of Health Sciences - Adana Health Practice 
      and Research Center, Adana, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20201207
PL  - England
TA  - Acta Cardiol
JT  - Acta cardiologica
JID - 0370570
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (SCUBE1 protein, human)
SB  - IM
MH  - Aged
MH  - Calcium-Binding Proteins
MH  - Coronary Angiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Myocardial Infarction
MH  - *Percutaneous Coronary Intervention
MH  - ROC Curve
MH  - *ST Elevation Myocardial Infarction/diagnosis/surgery
MH  - *Thrombosis/diagnosis
MH  - Treatment Outcome
OTO - NOTNLM
OT  - ST elevation myocardial infarction
OT  - Signal peptide-CUB-EGF domain-containing protein-1
OT  - thrombus burden
EDAT- 2020/12/08 06:00
MHDA- 2021/11/26 06:00
CRDT- 2020/12/07 08:43
PHST- 2020/12/08 06:00 [pubmed]
PHST- 2021/11/26 06:00 [medline]
PHST- 2020/12/07 08:43 [entrez]
AID - 10.1080/00015385.2020.1852753 [doi]
PST - ppublish
SO  - Acta Cardiol. 2021 Sep;76(7):777-784. doi: 10.1080/00015385.2020.1852753. Epub 
      2020 Dec 7.