PMID- 33283743
OWN - NLM
STAT- MEDLINE
DCOM- 20201208
LR  - 20201214
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 28
IP  - 6
DP  - 2020 Dec
TI  - [Analysis on Polymorphism of Platelet Antigen Gene in Shandong Han Population].
PG  - 2066-2070
LID - 10.19746/j.cnki.issn.1009-2137.2020.06.044 [doi]
AB  - OBJECTIVE: To study the Polymorphism of the human platelet antigen(HPA) gene 1-17 
      and human leukocyte antigen(HLA) gene-A and B locus in Shandong Han population. 
      METHODS: A total of 962 samples from routine voluntary platelet donors were 
      genotyped for HPA1-17 system and HLA-A site, B by PCR-SSP and PCR-SSOP 
      respectively．Gene frequencies were calculated by counting. HPA1-17 and HLA 
      genotype combinations were analyzed by Arelequin 3.5. RESULTS: The gene 
      frequencies of HPA-la, -1b, HPA-2a, -2b, HPA-3a, -3b, HPA-4a, -4b, HPA-5a, -5b, 
      HPA-6a, -6b, HPA-15a, -15b were 0.9918, 0.0082, 0.9419, 0.0592, 0.5841, 0.4174, 
      0.9969, 0.0031, 0.9892, 0.0108, 0.9835, 0.0175,0.5488 and 0.4512, respectively． 
      The most common HPA genotype combination was HPA-(1, 2, 4, 5, 6, 7-14, 16, 17) 
      aa-3ab-15ab (0.2048). Moreover, HLA-A*2(0.3094) and HLA-B*13(0.1513) showed the 
      highest frequency in their respective locus. The most common HLA genotype 
      combination was HLA-A*2-B*13(0.1397) . CONCLUSION: Distributions of HPA and HLA 
      show high polymorphism in Shandong Han population. The ethnic and territorial 
      difference of HPA distribution is also confirmed. It is imperative to establish 
      local genetic database of volunteer platelet donors.
FAU - Liu, Yan
AU  - Liu Y
AD  - HLA Laboratory, Blood Center of Shandong Province, Jinan 250014, Shandong 
      Province, China.
FAU - Zhu, Hai-Feng
AU  - Zhu HF
AD  - HLA Laboratory, Blood Center of Shandong Province, Jinan 250014, Shandong 
      Province, China.
FAU - Qiao, Wen-Ben
AU  - Qiao WB
AD  - HLA Laboratory, Blood Center of Shandong Province, Jinan 250014, Shandong 
      Province, China.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - HLA Laboratory, Blood Center of Shandong Province, Jinan 250014, Shandong 
      Province, China.
FAU - Song, Yong-Hong
AU  - Song YH
AD  - HLA Laboratory, Blood Center of Shandong Province, Jinan 250014, Shandong 
      Province, China.
FAU - Nie, Xiang-Min
AU  - Nie XM
AD  - HLA Laboratory, Blood Center of Shandong Province, Jinan 250014, Shandong 
      Province, China.
FAU - Zhu, Chuan-Fu
AU  - Zhu CF
AD  - HLA Laboratory, Blood Center of Shandong Province, Jinan 250014, Shandong 
      Province, China.
FAU - Zhai, Pei-Cong
AU  - Zhai PC
AD  - HLA Laboratory, Blood Center of Shandong Province, Jinan 250014, Shandong 
      Province, China,E-mail: sd1866011@163.com.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
RN  - 0 (Antigens, Human Platelet)
SB  - IM
MH  - Alleles
MH  - *Antigens, Human Platelet/genetics
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Polymorphism, Genetic
EDAT- 2020/12/08 06:00
MHDA- 2020/12/15 06:00
CRDT- 2020/12/07 08:43
PHST- 2020/12/07 08:43 [entrez]
PHST- 2020/12/08 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
AID - 1009-2137(2020)06-2066-05 [pii]
AID - 10.19746/j.cnki.issn.1009-2137.2020.06.044 [doi]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Dec;28(6):2066-2070. doi: 
      10.19746/j.cnki.issn.1009-2137.2020.06.044.