PMID- 33287232
OWN - NLM
STAT- MEDLINE
DCOM- 20210308
LR  - 20211204
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 23
DP  - 2020 Dec 3
TI  - Still Living Better through Chemistry: An Update on Caloric Restriction and 
      Caloric Restriction Mimetics as Tools to Promote Health and Lifespan.
LID - 10.3390/ijms21239220 [doi]
LID - 9220
AB  - Caloric restriction (CR), the reduction of caloric intake without inducing 
      malnutrition, is the most reproducible method of extending health and lifespan 
      across numerous organisms, including humans. However, with nearly one-third of 
      the world's population overweight, it is obvious that caloric restriction 
      approaches are difficult for individuals to achieve. Therefore, identifying 
      compounds that mimic CR is desirable to promote longer, healthier lifespans 
      without the rigors of restricting diet. Many compounds, such as rapamycin (and 
      its derivatives), metformin, or other naturally occurring products in our diets 
      (nutraceuticals), induce CR-like states in laboratory models. An alternative to 
      CR is the removal of specific elements (such as individual amino acids) from the 
      diet. Despite our increasing knowledge of the multitude of CR approaches and CR 
      mimetics, the extent to which these strategies overlap mechanistically remains 
      unclear. Here we provide an update of CR and CR mimetic research, summarizing 
      mechanisms by which these strategies influence genome function required to treat 
      age-related pathologies and identify the molecular fountain of youth.
FAU - Almendariz-Palacios, Carla
AU  - Almendariz-Palacios C
AUID- ORCID: 0000-0003-0744-6956
AD  - Department of Food and Bioproduct Sciences, University of Saskatchewan, 
      Saskatoon, SK S7N 4A8, Canada.
FAU - Mousseau, Darrell D
AU  - Mousseau DD
AD  - Cell Signalling Laboratory, Department of Psychiatry, University of Saskatchewan, 
      Saskatoon, SK S7N 5E5, Canada.
FAU - Eskiw, Christopher H
AU  - Eskiw CH
AD  - Department of Food and Bioproduct Sciences, University of Saskatchewan, 
      Saskatoon, SK S7N 4A8, Canada.
AD  - Department of Biochemistry, Microbiology and Immunology, University of 
      Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
FAU - Gillespie, Zoe E
AU  - Gillespie ZE
AD  - Department of Biochemistry, Microbiology and Immunology, University of 
      Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
LA  - eng
GR  - UKWN/CAPMC/CIHR/Canada
GR  - UKWN/Natural Sciences and Engineering Council of Canada/
GR  - UKWN/Saskatchewan Research Chair in Alzheimer Disease and Related Dementias 
      funded by the Alzheimer Society of Saskatchewan and the Saskatchewan Health 
      Research Foundation/
GR  - NA/University of Saskatchewan College of Graduate and Postdoctoral Studies/
GR  - NA/Vanier Canada Graduate Scholarship/
PT  - Journal Article
PT  - Review
DEP - 20201203
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Amino Acids)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Amino Acids/metabolism
MH  - Animals
MH  - *Caloric Restriction
MH  - Cellular Senescence
MH  - Diet
MH  - Energy Intake
MH  - *Health Promotion
MH  - Humans
MH  - *Longevity
MH  - Molecular Mimicry
MH  - TOR Serine-Threonine Kinases/metabolism
PMC - PMC7729921
OTO - NOTNLM
OT  - amino acid restriction
OT  - caloric restriction
OT  - caloric restriction mimetics
OT  - general control nonderepressible 2 (GCN2)
OT  - healthspan
OT  - lifespan
OT  - mammalian target of rapamycin (mTOR)
COIS- The authors declare no conflict of interest.
EDAT- 2020/12/09 06:00
MHDA- 2021/03/09 06:00
PMCR- 2020/12/01
CRDT- 2020/12/08 01:07
PHST- 2020/11/07 00:00 [received]
PHST- 2020/11/30 00:00 [revised]
PHST- 2020/11/30 00:00 [accepted]
PHST- 2020/12/08 01:07 [entrez]
PHST- 2020/12/09 06:00 [pubmed]
PHST- 2021/03/09 06:00 [medline]
PHST- 2020/12/01 00:00 [pmc-release]
AID - ijms21239220 [pii]
AID - ijms-21-09220 [pii]
AID - 10.3390/ijms21239220 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Dec 3;21(23):9220. doi: 10.3390/ijms21239220.