PMID- 33287508
OWN - NLM
STAT- MEDLINE
DCOM- 20201209
LR  - 20201214
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 49
IP  - 12
DP  - 2020 Dec 8
TI  - [Atypical renal cysts: a clinicopathological and molecular analysis of six 
      cases].
PG  - 1249-1254
LID - 10.3760/cma.j.cn112151-20200324-00250 [doi]
AB  - Objective: To investigate the clinicopathological characteristics and molecular 
      genetics of atypical renal cysts. Methods: Six cases of atypical renal cysts were 
      collected from Zhejiang Provincial People's Hospital, Hangzhou, China, between 
      February 2014 and February 2019. The clinicopathological characteristics and 
      disease progression were analyzed. The 3p deletion and trisomy of chromosomes 7 
      and 17 were detected using fluorescence in situ hybridization (FISH). Results: 
      All of the 6 patients were male, aged 43-63 years (median: 52 years). 
      Preoperative Bosniak classification showed 4 cases of grade Ⅱ, 1 case of grade Ⅰ 
      and 1 of grade Ⅲ. Histologically, atypical renal cysts appeared as unilocular or 
      multilocular cysts, lined by multilayered flattened or cuboidal-shaped clear or 
      eosinophilic cells. They often showed short papillary projections, and lacked 
      solid or nodular growth of the lesional cells within the wall or septa of the 
      cysts. Histologically, these cysts could be classified into three categories: 
      acquired cystic disease-associated renal cell carcinoma (ACKD-RCC)-like (3 
      cases), clear cell type (2 cases), and eosinophilic papillary type (1 case). Two 
      cases of ACKD-RCC-like atypical renal cysts were accompanied by clear cell renal 
      cell carcinomas. On immunohistochemical staining, ACKD-RCC-like atypical renal 
      cysts were focally CK7+/AMACR+/CD57+, the clear-cell type atypical renal cysts 
      were CK7+/CAⅨ+, and eosinophilic papillary type atypical renal cysts were 
      CK7+/AMACR+. FISH analyses showed that one case of ACKD-RCC-like atypical renal 
      cysts had trisomy 17 and one case of clear cell type had 3p deletion, while no 
      signal abnormality was detected in the other cases. The six patients were 
      followed up for 13 to 70 months (median: 27 months), and no evidence of renal 
      cell carcinoma was noted. Conclusion: Atypical renal cysts are a group of lesions 
      that are heterogeneous in clinical, histological and immunophenotypical and 
      molecular genetic features. FISH analyses suggest that a subset of the cases may 
      be precursors of currently known renal cell carcinomas. Extensively sampling and 
      careful observation of the histological characteristics of the cyst wall are 
      important for distinguishing atypical renal cysts from extensively cystic renal 
      cell carcinomas.
FAU - Chen, Y
AU  - Chen Y
AD  - Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital 
      of Hangzhou Medical College, Hangzhou 310014, China.
FAU - Zhong, L
AU  - Zhong L
AD  - Department of Pathology, the First Affiliated Hospital of Dalian Medical 
      University, Dalian 116011, China.
FAU - Yang, Z R
AU  - Yang ZR
AD  - Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital 
      of Hangzhou Medical College, Hangzhou 310014, China.
FAU - Ru, G Q
AU  - Ru GQ
AD  - Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital 
      of Hangzhou Medical College, Hangzhou 310014, China.
FAU - He, X L
AU  - He XL
AD  - Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital 
      of Hangzhou Medical College, Hangzhou 310014, China.
FAU - Teng, X D
AU  - Teng XD
AD  - Department of Pathology, the First Affiliated Hospital of Zhejiang University 
      School of Medicine, Hangzhou 310003, China.
FAU - Zhao, M
AU  - Zhao M
AD  - Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital 
      of Hangzhou Medical College, Hangzhou 310014, China.
LA  - chi
GR  - 2018KY246/Zhejiang Provincial Medicine and Health Research Foundation/
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
SB  - IM
MH  - Adult
MH  - China
MH  - *Cysts
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Kidney Diseases, Cystic/genetics
MH  - *Kidney Neoplasms/genetics/surgery
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Atypical renal cysts
OT  - Diagnosis, differential
OT  - Fluorescence in situ hybridization
OT  - Renal cell carcinoma
EDAT- 2020/12/09 06:00
MHDA- 2020/12/15 06:00
CRDT- 2020/12/08 03:22
PHST- 2020/12/08 03:22 [entrez]
PHST- 2020/12/09 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
AID - 10.3760/cma.j.cn112151-20200324-00250 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2020 Dec 8;49(12):1249-1254. doi: 
      10.3760/cma.j.cn112151-20200324-00250.