PMID- 3328783
OWN - NLM
STAT- MEDLINE
DCOM- 19880513
LR  - 20190510
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 393
DP  - 1987 Dec
TI  - Salt appetite in the pigeon in response to pharmacological treatments.
PG  - 555-68
AB  - 1. In response to furosemide-induced sodium depletion pigeons showed a robust 
      salt appetite. Following the 1st depletion they started to ingest 3% NaCl after a 
      latency of 373 +/- 69 s and in 24 h they took 21.16 +/- 3.07 ml of this solution 
      (vs. a daily mean intake of 1-2 ml prior to the depletion). 2. The appetite was 
      selective as shown by the fact that when, after depletion, 0.34 M-CaCl2 was 
      offered (which is equiosmotic to 3% NaCl) pigeons took just a trivial amount of 
      it. 3. Analysis of sodium losses following the natriuretic treatment revealed 
      that pigeons respond to sodium depletion with an excessive overconsumption of 
      NaCl solution. In the 2 h after access to salt they took about 3 times the amount 
      of sodium lost. 4. Repeated sodium depletions sharply reduced the latency to the 
      ingestion of salt and produced larger intakes. However, the overall amount of 
      salt taken in 24 h after the later depletions was very similar and statistically 
      indistinguishable from that taken following the 1st depletion. 5. Subchronic 
      deoxycorticosterone acetate treatment (2 mg pigeon-1 day-1 I.M.) increased daily 
      3% NaCl intake, but large variability was observed in the response. 4 mg pigeon-1 
      day-1 evoked a reliable 3% NaCl intake which was particularly marked from the 5th 
      day of the treatment. 6. Pulse intracerebroventricular (I.C.V.) injection of 
      purified hog renin evoked water intake within about 1 min of injection, followed 
      (about 6 h later) by increased salt intake. In the 24 h after renin injection 
      pigeons took 16.58 +/- 2.89 ml of 3% NaCl. On the 2nd day following injection 
      salt intake was still higher than in controls. 7. In conclusion, our results show 
      that pigeons respond to sodium depletion with a robust salt appetite. Moreover, 
      salt appetite can be evoked by deoxycorticosterone acetate as well as by renin. 
      These findings suggest that in the pigeon salt appetite may be an 
      endocrine-induced behaviour controlled by mineralocorticoids and by the 
      renin-angiotensin system.
FAU - Epstein, A N
AU  - Epstein AN
AD  - Department of Biology, University of Pennsylvania, Philadelphia 19104.
FAU - Massi, M
AU  - Massi M
LA  - eng
GR  - 1 FO5 TW3689-01 BI-5/TW/FIC NIH HHS/United States
GR  - NS 03469/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
RN  - 0 (Sodium, Dietary)
RN  - 40GP35YQ49 (Desoxycorticosterone)
RN  - 7LXU5N7ZO5 (Furosemide)
RN  - EC 3.4.23.15 (Renin)
SB  - IM
MH  - Animals
MH  - Appetite/*drug effects
MH  - Columbidae/*physiology
MH  - Desoxycorticosterone/pharmacology
MH  - Furosemide/pharmacology
MH  - Male
MH  - Renin/pharmacology
MH  - Sodium, Dietary/*metabolism
PMC - PMC1192410
EDAT- 1987/12/01 00:00
MHDA- 1987/12/01 00:01
PMCR- 1987/12/01
CRDT- 1987/12/01 00:00
PHST- 1987/12/01 00:00 [pubmed]
PHST- 1987/12/01 00:01 [medline]
PHST- 1987/12/01 00:00 [entrez]
PHST- 1987/12/01 00:00 [pmc-release]
AID - 10.1113/jphysiol.1987.sp016840 [doi]
PST - ppublish
SO  - J Physiol. 1987 Dec;393:555-68. doi: 10.1113/jphysiol.1987.sp016840.