PMID- 33289174
OWN - NLM
STAT- Publisher
LR  - 20240222
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
DP  - 2020 Dec 1
TI  - Risk factors for the development of high-grade dysplasia and carcinoma in 
      patients with laryngeal squamous cell papillomas: Large retrospective cohort 
      study.
LID - 10.1002/hed.26560 [doi]
AB  - BACKGROUND: The incidence and risk factors for the development of high-grade 
      dysplasia (HG-D) and laryngeal squamous cell carcinoma (LSCC) were assessed in 
      patients with laryngeal squamous cell papillomas (LSP). METHODS: Clinical data, 
      human papillomaviruses (HPV) typing, HPV E6/E7 mRNA in situ hybridization, and 
      sequencing of host genes in LSP biopsies of 163 patients were analyzed. RESULTS: 
      Progression to HG-D and LSCC was identified in 21.5% and 4.3% of LSP patients, 
      respectively. A more advanced age at LSP onset and lack of HPV infection were 
      detected as risk factors for the development of HG-D and LSCC (P < .05). The 
      identification of HG-D was associated with its progression to LSCC (P < .05). 
      Host gene mutations were identified in 3 of 7 patients with LSCC. CONCLUSIONS: 
      The histological monitoring of LSP and HPV typing are necessary for early 
      detection of epithelial changes. Further research is needed to elucidate the role 
      of host gene mutations in LSCC transformation.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Gluvajic, Dasa
AU  - Gluvajic D
AUID- ORCID: 0000-0002-0125-9650
AD  - Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical 
      Centre, Ljubljana, Slovenia.
FAU - Hosnjak, Lea
AU  - Hosnjak L
AD  - Institute of Microbiology and Immunology, Faculty of Medicine, University of 
      Ljubljana, Slovenia.
FAU - Stegel, Vida
AU  - Stegel V
AD  - Department of Molecular Diagnostics, Institute of Oncology, Ljubljana, Slovenia.
FAU - Novakovic, Srdjan
AU  - Novakovic S
AD  - Department of Molecular Diagnostics, Institute of Oncology, Ljubljana, Slovenia.
FAU - Gale, Nina
AU  - Gale N
AUID- ORCID: 0000-0002-8921-5109
AD  - Institute of Pathology, Faculty of Medicine, University of Ljubljana, Slovenia.
FAU - Poljak, Mario
AU  - Poljak M
AD  - Institute of Microbiology and Immunology, Faculty of Medicine, University of 
      Ljubljana, Slovenia.
FAU - Boltezar, Irena Hocevar
AU  - Boltezar IH
AD  - Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical 
      Centre, Ljubljana, Slovenia.
LA  - eng
GR  - P3-0083/Javna Agencija za Raziskovalno Dejavnost RS/
GR  - 20150093/University Medical Centre, Ljubljana, Slovenia/
PT  - Journal Article
DEP - 20201201
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
SB  - IM
OTO - NOTNLM
OT  - carcinoma
OT  - dysplasia
OT  - human papilloma virus
OT  - larynx
OT  - papilloma
EDAT- 2020/12/09 06:00
MHDA- 2020/12/09 06:00
CRDT- 2020/12/08 05:47
PHST- 2020/06/23 00:00 [received]
PHST- 2020/10/16 00:00 [revised]
PHST- 2020/11/18 00:00 [accepted]
PHST- 2020/12/08 05:47 [entrez]
PHST- 2020/12/09 06:00 [pubmed]
PHST- 2020/12/09 06:00 [medline]
AID - 10.1002/hed.26560 [doi]
PST - aheadofprint
SO  - Head Neck. 2020 Dec 1. doi: 10.1002/hed.26560.