PMID- 33289611 OWN - NLM STAT- MEDLINE DCOM- 20210421 LR - 20220202 IS - 1527-1315 (Electronic) IS - 0033-8419 (Print) IS - 0033-8419 (Linking) VI - 298 IP - 2 DP - 2021 Feb TI - Improved Task-based Functional MRI Language Mapping in Patients with Brain Tumors through Marchenko-Pastur Principal Component Analysis Denoising. PG - 365-373 LID - 10.1148/radiol.2020200822 [doi] AB - Background Functional MRI improves preoperative planning in patients with brain tumors, but task-correlated signal intensity changes are only 2%-3% above baseline. This makes accurate functional mapping challenging. Marchenko-Pastur principal component analysis (MP-PCA) provides a novel strategy to separate functional MRI signal from noise without requiring user input or prior data representation. Purpose To determine whether MP-PCA denoising improves activation magnitude for task-based functional MRI language mapping in patients with brain tumors. Materials and Methods In this Health Insurance Portability and Accountability Act-compliant study, MP-PCA performance was first evaluated by using simulated functional MRI data with a known ground truth. Right-handed, left-language-dominant patients with brain tumors who successfully performed verb generation, sentence completion, and finger tapping functional MRI tasks were retrospectively identified between January 2017 and August 2018. On the group level, for each task, histograms of z scores for original and MP-PCA denoised data were extracted from relevant regions and contralateral homologs were seeded by a neuroradiologist blinded to functional MRI findings. Z scores were compared with paired two-sided t tests, and distributions were compared with effect size measurements and the Kolmogorov-Smirnov test. The number of voxels with a z score greater than 3 was used to measure task sensitivity relative to task duration. Results Twenty-three patients (mean age +/- standard deviation, 43 years +/- 18; 13 women) were evaluated. MP-PCA denoising led to a higher median z score of task-based functional MRI voxel activation in left hemisphere cortical regions for verb generation (from 3.8 +/- 1.0 to 4.5 +/- 1.4; P < .001), sentence completion (from 3.7 +/- 1.0 to 4.3 +/- 1.4; P < .001), and finger tapping (from 6.9 +/- 2.4 to 7.9 +/- 2.9; P < .001). Median z scores did not improve in contralateral homolog regions for verb generation (from -2.7 +/- 0.54 to -2.5 +/- 0.40; P = .90), sentence completion (from -2.3 +/- 0.21 to -2.4 +/- 0.37; P = .39), or finger tapping (from -2.3 +/- 1.20 to -2.7 +/- 1.40; P = .07). Individual functional MRI task durations could be truncated by at least 40% after MP-PCA without degradation of clinically relevant correlations between functional cortex and functional MRI tasks. Conclusion Denoising with Marchenko-Pastur principal component analysis led to higher task correlations in relevant cortical regions during functional MRI language mapping in patients with brain tumors. (c) RSNA, 2020 Online supplemental material is available for this article. FAU - Ades-Aron, Benjamin AU - Ades-Aron B AUID- ORCID: 0000-0001-5077-3341 AD - From the Center for Biomedical Imaging, Department of Radiology (B.A.A., G.L., J.V., E.F., D.S.N., T.S.) and Department of Neurosurgery (J.G.), New York University School of Medicine, 2nd Floor, 660 First Ave, New York, NY 10016; and Department of Electrical and Computer Engineering, New York University Tandon School of Engineering, New York, NY (B.A.A.). FAU - Lemberskiy, Gregory AU - Lemberskiy G AUID- ORCID: 0000-0002-8336-7486 AD - From the Center for Biomedical Imaging, Department of Radiology (B.A.A., G.L., J.V., E.F., D.S.N., T.S.) and Department of Neurosurgery (J.G.), New York University School of Medicine, 2nd Floor, 660 First Ave, New York, NY 10016; and Department of Electrical and Computer Engineering, New York University Tandon School of Engineering, New York, NY (B.A.A.). FAU - Veraart, Jelle AU - Veraart J AUID- ORCID: 0000-0003-0781-0420 AD - From the Center for Biomedical Imaging, Department of Radiology (B.A.A., G.L., J.V., E.F., D.S.N., T.S.) and Department of Neurosurgery (J.G.), New York University School of Medicine, 2nd Floor, 660 First Ave, New York, NY 10016; and Department of Electrical and Computer Engineering, New York University Tandon School of Engineering, New York, NY (B.A.A.). FAU - Golfinos, John AU - Golfinos J AD - From the Center for Biomedical Imaging, Department of Radiology (B.A.A., G.L., J.V., E.F., D.S.N., T.S.) and Department of Neurosurgery (J.G.), New York University School of Medicine, 2nd Floor, 660 First Ave, New York, NY 10016; and Department of Electrical and Computer Engineering, New York University Tandon School of Engineering, New York, NY (B.A.A.). FAU - Fieremans, Els AU - Fieremans E AUID- ORCID: 0000-0002-1384-8591 AD - From the Center for Biomedical Imaging, Department of Radiology (B.A.A., G.L., J.V., E.F., D.S.N., T.S.) and Department of Neurosurgery (J.G.), New York University School of Medicine, 2nd Floor, 660 First Ave, New York, NY 10016; and Department of Electrical and Computer Engineering, New York University Tandon School of Engineering, New York, NY (B.A.A.). FAU - Novikov, Dmitry S AU - Novikov DS AD - From the Center for Biomedical Imaging, Department of Radiology (B.A.A., G.L., J.V., E.F., D.S.N., T.S.) and Department of Neurosurgery (J.G.), New York University School of Medicine, 2nd Floor, 660 First Ave, New York, NY 10016; and Department of Electrical and Computer Engineering, New York University Tandon School of Engineering, New York, NY (B.A.A.). FAU - Shepherd, Timothy AU - Shepherd T AUID- ORCID: 0000-0003-0232-1636 AD - From the Center for Biomedical Imaging, Department of Radiology (B.A.A., G.L., J.V., E.F., D.S.N., T.S.) and Department of Neurosurgery (J.G.), New York University School of Medicine, 2nd Floor, 660 First Ave, New York, NY 10016; and Department of Electrical and Computer Engineering, New York University Tandon School of Engineering, New York, NY (B.A.A.). LA - eng GR - P30 AG066512/AG/NIA NIH HHS/United States GR - P41 EB017183/EB/NIBIB NIH HHS/United States GR - R01 EB027075/EB/NIBIB NIH HHS/United States GR - R01 NS088040/NS/NINDS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20201208 PL - United States TA - Radiology JT - Radiology JID - 0401260 SB - IM CIN - Radiology. 2021 Apr;299(1):49-50. PMID: 33595393 MH - Adolescent MH - Adult MH - Aged MH - Brain/diagnostic imaging MH - Brain Mapping/*methods MH - Brain Neoplasms/*diagnostic imaging MH - Child MH - Female MH - Humans MH - Image Interpretation, Computer-Assisted/*methods MH - Magnetic Resonance Imaging/*methods/statistics & numerical data MH - Male MH - Middle Aged MH - Principal Component Analysis MH - Retrospective Studies MH - Young Adult PMC - PMC7850264 EDAT- 2020/12/09 06:00 MHDA- 2021/04/22 06:00 PMCR- 2022/02/01 CRDT- 2020/12/08 12:16 PHST- 2020/12/09 06:00 [pubmed] PHST- 2021/04/22 06:00 [medline] PHST- 2020/12/08 12:16 [entrez] PHST- 2022/02/01 00:00 [pmc-release] AID - 10.1148/radiol.2020200822 [doi] PST - ppublish SO - Radiology. 2021 Feb;298(2):365-373. doi: 10.1148/radiol.2020200822. Epub 2020 Dec 8.