PMID- 33290807
OWN - NLM
STAT- MEDLINE
DCOM- 20210614
LR  - 20220110
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 147
DP  - 2021 Jan
TI  - Seed peptide lunasin ameliorates obesity-induced inflammation and regulates 
      immune responses in C57BL/6J mice fed high-fat diet.
PG  - 111908
LID - S0278-6915(20)30798-5 [pii]
LID - 10.1016/j.fct.2020.111908 [doi]
AB  - Obesity causes immune cells to infiltrate into adipose tissues and secrete 
      proinflammatory mediators, promoting the development of chronic diseases. The 
      seed peptide lunasin has been reported to have several bioactivities. We aimed to 
      investigate the immunomodulatory properties of lunasin in obese models. Female 
      and male C57BL/6J mice were divided into three groups: low-fat diet (LF), 
      high-fat diet (HF), and HF with an intraperitoneal injection of lunasin (HFL). In 
      females, lunasin decreased the levels of monocyte chemoattractant protein-1 
      (MCP-1), interleukin (IL)-1beta, and tumor necrosis factor (TNF-alpha) produced in 
      peritoneal macrophages, indicating a decrease in F4/80+ macrophage infiltration, 
      especially the CD11c + M1 phenotype. Serum leptin and tissue-oxidized lipid 
      malondialdehyde levels were decreased in the HFL group. In males, lunasin 
      normalized the obesity-induced increase in spleen size and splenocyte numbers. 
      Moreover, lunasin inhibited IL-6 secretion while promoting interferon gamma 
      (IFN-gamma) and IL-2 production in the splenocytes. In vitro, lunasin increased EL-4 
      T-cell proliferation and IL-2 production in activated T cells under obese 
      conditions. Thus, lunasin is a potential natural compound that promotes 
      immunomodulation in both female and male obese mice in a sex-dependent manner. 
      Furthermore, lunasin mediates the anti-inflammatory response and enhances the T 
      helper type 1 cell response to obesity-related immune disorders.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Hsieh, Chia-Chien
AU  - Hsieh CC
AD  - Undergraduate and Graduate Programs of Nutrition Science, School of Life Science, 
      National Taiwan Normal University, Taipei, 10610, Taiwan. Electronic address: 
      hsieh@ntnu.edu.tw.
FAU - Wang, Yen-Fang
AU  - Wang YF
AD  - Undergraduate and Graduate Programs of Nutrition Science, School of Life Science, 
      National Taiwan Normal University, Taipei, 10610, Taiwan. Electronic address: 
      60606061e@gmail.com.
FAU - Lin, Pin-Yu
AU  - Lin PY
AD  - Undergraduate and Graduate Programs of Nutrition Science, School of Life Science, 
      National Taiwan Normal University, Taipei, 10610, Taiwan. Electronic address: 
      zelobabee030@gmail.com.
FAU - Peng, Shih-Han
AU  - Peng SH
AD  - Undergraduate and Graduate Programs of Nutrition Science, School of Life Science, 
      National Taiwan Normal University, Taipei, 10610, Taiwan. Electronic address: 
      abucute0806@gmail.com.
FAU - Chou, Mei-Jia
AU  - Chou MJ
AD  - Undergraduate and Graduate Programs of Nutrition Science, School of Life Science, 
      National Taiwan Normal University, Taipei, 10610, Taiwan. Electronic address: 
      u9908036@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20201205
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Cytokines)
RN  - 0 (GM2S-1 protein, soybean)
RN  - 0 (Soybean Proteins)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Cell Proliferation/drug effects
MH  - Cytokines/genetics/metabolism
MH  - Diet, High-Fat/*adverse effects
MH  - Female
MH  - Gene Expression Regulation/drug effects
MH  - Inflammation/*etiology/*prevention & control
MH  - Macrophages, Peritoneal/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Obesity/*chemically induced/*prevention & control
MH  - Random Allocation
MH  - Soybean Proteins/*pharmacology
MH  - Spleen/cytology
MH  - T-Lymphocytes/drug effects/physiology
OTO - NOTNLM
OT  - Cytokine
OT  - Immunomodulation
OT  - Inflammation
OT  - Lunasin
OT  - Obesity
EDAT- 2020/12/09 06:00
MHDA- 2021/06/16 06:00
CRDT- 2020/12/08 20:08
PHST- 2020/07/11 00:00 [received]
PHST- 2020/11/26 00:00 [revised]
PHST- 2020/12/02 00:00 [accepted]
PHST- 2020/12/09 06:00 [pubmed]
PHST- 2021/06/16 06:00 [medline]
PHST- 2020/12/08 20:08 [entrez]
AID - S0278-6915(20)30798-5 [pii]
AID - 10.1016/j.fct.2020.111908 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2021 Jan;147:111908. doi: 10.1016/j.fct.2020.111908. Epub 2020 
      Dec 5.