PMID- 33291595
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201226
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 9
IP  - 12
DP  - 2020 Dec 4
TI  - Standardized Bacopa monnieri Extract Ameliorates Learning and Memory Impairments 
      through Synaptic Protein, Neurogranin, Pro-and Mature BDNF Signaling, and HPA 
      Axis in Prenatally Stressed Rat Offspring.
LID - 10.3390/antiox9121229 [doi]
LID - 1229
AB  - Prenatal stress (PNS) influences offspring neurodevelopment, inducing 
      anxiety-like behavior and memory deficits. We investigated whether pretreatment 
      of Bacopa monnieri extract (CDRI-08/BME) ameliorates PNS-induced changes in 
      signaling molecules, and changes in the behavior of Wistar rat offspring. 
      Pregnant rats were randomly assigned into control (CON)/prenatal stress (PNS)/PNS 
      and exposed to BME treatment (PNS + BME). Dams were exposed to stress by placing 
      them in a social defeat cage, where they observed social defeat from gestational 
      day (GD)-16-18. Pregnant rats in the PNS + BME group were given BME treatment 
      from GD-10 to their offspring's postnatal day (PND)-23, and to their offspring 
      from PND-15 to -30. PNS led to anxiety-like behavior; impaired memory; increased 
      the level of corticosterone (CORT), adrenocorticotropic hormone, glucocorticoid 
      receptor, pro-apoptotic Casepase-3, and 5-HT(2C) receptor; decreased 
      anti-apoptotic Bcl-2, synaptic proteins (synaptophysin, synaptotagmin-1), 
      5-HT(1A,) receptor, phosphorylation of calmodulin-dependent protein kinase 
      II/neurogranin, N-methyl-D-aspartate receptors (2A,2B), postsynaptic density 
      protein 95; and conversion of pro and mature brain derived neurotropic factor in 
      their offspring. The antioxidant property of BME possibly inhibiting the 
      PNS-induced changes in observed molecules, anxiety-like behavior, and memory 
      deficits. The observed results suggest that pretreatment of BME could be an 
      effective coping strategy to prevent PNS-induced behavioral impairments in their 
      offspring.
FAU - Sivasangari, Karunanithi
AU  - Sivasangari K
AD  - Department of Animal Science, Behavioural Neuroscience Laboratory, Bharathidasan 
      University, Tiruchirappalli 620024, India.
FAU - Rajan, Koilmani Emmanuvel
AU  - Rajan KE
AD  - Department of Animal Science, Behavioural Neuroscience Laboratory, Bharathidasan 
      University, Tiruchirappalli 620024, India.
LA  - eng
GR  - SR/PURSE Phase-II/16G/Department of Science and Technology, Ministry of Science 
      and Technology, India/
PT  - Journal Article
DEP - 20201204
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC7761874
OTO - NOTNLM
OT  - Bacopa monnieri
OT  - N-methyl-D-aspartate receptor (NMDAR)
OT  - brain-derived neurotropic factor (BDNF)
OT  - caspase-3
OT  - prenatal stress
OT  - synaptophysin
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/12/10 06:00
MHDA- 2020/12/10 06:01
PMCR- 2020/12/04
CRDT- 2020/12/09 01:02
PHST- 2020/11/04 00:00 [received]
PHST- 2020/11/19 00:00 [revised]
PHST- 2020/11/24 00:00 [accepted]
PHST- 2020/12/09 01:02 [entrez]
PHST- 2020/12/10 06:00 [pubmed]
PHST- 2020/12/10 06:01 [medline]
PHST- 2020/12/04 00:00 [pmc-release]
AID - antiox9121229 [pii]
AID - antioxidants-09-01229 [pii]
AID - 10.3390/antiox9121229 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2020 Dec 4;9(12):1229. doi: 10.3390/antiox9121229.