PMID- 33292292 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201212 IS - 1743-7075 (Print) IS - 1743-7075 (Electronic) IS - 1743-7075 (Linking) VI - 17 IP - 1 DP - 2020 Nov 19 TI - Nerve growth factor is closely related to glucose metabolism, insulin sensitivity and insulin secretion in the second trimester: a case-control study in Chinese. PG - 98 LID - 10.1186/s12986-020-00523-2 [doi] LID - 98 AB - OBJECTIVE: Inflammation-related factors have been shown to play a significant role throughout pregnancy. In this study, we aimed to explore the relationships between selected inflammatory cytokines and gestational diabetes (GDM) in Chinese pregnant women. DESIGN AND METHODS: This was a 1:1 matched case-control study that included 200 pairs of subjects in the second trimester and 130 pairs of subjects in the third trimester. Serum levels of nerve growth factor (NGF), Interleukin-6 (IL-6), leptin, Interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha) and Interleukin-1beta (IL-1beta) were measured by enzyme immunoassay. The associations of these inflammatory factors with metabolic parameters were analysed. RESULTS: In the second trimester, GDM patients had higher NGF levels and lower IL-8 levels than did normal controls (P < 0.001 and P = 0.015, respectively). However, in the third trimester, only lower leptin levels were observed in the GDM group (P = 0.031). Additionally, in the second trimester, NGF levels were not only positively associated with fasting, 1-h and 2-h glucose levels and the area under curve of glucose, but also positively related to insulin sensitivity and secretion, as suggested by fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment index of beta-cell secretion (HOMA-beta) (all P < 0.05). Moreover, IL-6 and leptin levels were positively correlated with HOMA-IR and HOMA-beta, and TNF-alpha levels were positively related to HOMA-IR (all P < 0.05). Except for the relationships between NGF and HOMA-beta and TNF-alpha and HOMA-IR, the other correlations still existed even after adjusting for confounding factors (all P < 0.05). CONCLUSION: In addition to the positive associations of IL-6 and leptin with insulin resistance and secretion, NGF was higher in the GDM patients and strongly linked to glucose metabolism, insulin resistance and pancreatic beta cell function in Chinese pregnant women in the second trimester. FAU - Tang, Mengyang AU - Tang M AD - The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China. AD - Department of Endocrinology and Metabolism, Fengxian Central Hospital Affiliated to the Southern Medical University, Shanghai, China. FAU - Luo, Mingjuan AU - Luo M AD - The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China. AD - Department of Endocrinology and Metabolism, Fengxian Central Hospital Affiliated to the Southern Medical University, Shanghai, China. AD - Department of Endocrinology and Metabolism, University of Hong Kong Shenzhen Hospital, Shenzhen, China. FAU - Lu, Wenqian AU - Lu W AD - The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China. AD - Department of Endocrinology and Metabolism, Fengxian Central Hospital Affiliated to the Southern Medical University, Shanghai, China. FAU - Zhang, Rong AU - Zhang R AD - Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. FAU - Liang, Wei AU - Liang W AD - Department of Endocrinology and Metabolism, University of Hong Kong Shenzhen Hospital, Shenzhen, China. FAU - Gu, Jianfen AU - Gu J AD - Department of Endocrinology and Metabolism, University of Hong Kong Shenzhen Hospital, Shenzhen, China. FAU - Yu, Xuemei AU - Yu X AD - The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China. AD - Department of Endocrinology and Metabolism, Fengxian Central Hospital Affiliated to the Southern Medical University, Shanghai, China. FAU - Zhang, Xueli AU - Zhang X AD - The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China. AD - Department of Endocrinology and Metabolism, Fengxian Central Hospital Affiliated to the Southern Medical University, Shanghai, China. FAU - Hu, Cheng AU - Hu C AUID- ORCID: 0000-0003-4314-2386 AD - The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China. alfredhc@sjtu.edu.cn. AD - Department of Endocrinology and Metabolism, Fengxian Central Hospital Affiliated to the Southern Medical University, Shanghai, China. alfredhc@sjtu.edu.cn. AD - Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. alfredhc@sjtu.edu.cn. LA - eng GR - 2016YFC1304902/the National Key Research and Development Project of China/ GR - 81570713 and 91649112/National Science Foundation of China/ GR - 2017BR008/Outstanding Academic Leaders of Shanghai Health System/ PT - Journal Article DEP - 20201119 PL - England TA - Nutr Metab (Lond) JT - Nutrition & metabolism JID - 101231644 PMC - PMC7678221 OTO - NOTNLM OT - Gestational diabetes OT - Glucose metabolism OT - Inflammatory cytokines OT - Nerve growth factor COIS- The authors declare no conflict of interest. EDAT- 2020/12/10 06:00 MHDA- 2020/12/10 06:01 PMCR- 2020/11/19 CRDT- 2020/12/09 05:42 PHST- 2020/07/10 00:00 [received] PHST- 2020/11/10 00:00 [accepted] PHST- 2020/12/09 05:42 [entrez] PHST- 2020/12/10 06:00 [pubmed] PHST- 2020/12/10 06:01 [medline] PHST- 2020/11/19 00:00 [pmc-release] AID - 10.1186/s12986-020-00523-2 [pii] AID - 523 [pii] AID - 10.1186/s12986-020-00523-2 [doi] PST - epublish SO - Nutr Metab (Lond). 2020 Nov 19;17(1):98. doi: 10.1186/s12986-020-00523-2.